With the gestation and development of new technologies, new products, new formats, and new models, venture capital investment, as one of the most important forms of open innovation in large companies, plays an increasingly important role in the innovation of mature large companies and entrepreneurial enterprises. To deal with the complex and dynamic environment, the niche of Corporate Venture Capital (CVC) ecological community is investigated from the perspective of the innovation ecosystem. By analyzing the innovation of CVC ecological community with the use of the logistic expansion model, this paper analyzes the stability of evolution game through the replicator dynamic equation and discusses ten parameters of niche state. In the end, we conclude that there are four optimization strategies in the coevolution of major corporations and entrepreneurial firms, namely, niche separation, niche expansion, niche K-R, and niche alliance.