Vibsanoids A–D, four new subtypes of vibsane diterpenoids with a distinctive tricyclo[8.2.1.0^2,9]tridecane core fromViburnum odoratissimum

Abstract

Four highly rearranged tetranorvibsane-type diterpenoids, vibsanoids A‒D (1‒4), were isolated from the leaves of Viburnum odoratissimum with a molecular networking strategy. Compounds 1‒4 represented a new vibsane diterpenoid subtype possessing...

Clerodane diterpenoids with anti-inflammatory and synergistic antibacterial activities from Tinospora crispa

“…The anti-inflammatory activities of 14 clerodane diterpenoids were measured using the previously reported methods with minor modifications. 33,34 Briefly, the microglial BV-2 cells were cultured in DMEM supplemented with 10% FBS and seeded in 96-well cell culture plates at a density of 4 × 10 4 cells per well. After incubation under 5% CO 2 at 37 °C for 24 h, the cells were treated with different concentrations of 14 clerodane diterpenoids in the presence of LPS (200 ng mL −1 ).…”

Isolation of cytotoxic daphnane-type and tigliane-type diterpenoids from Daphne genkwa using MetGem software

“…17–20 In our previous work, a unique caged tetracyclo sesquiterpenoid and a series of terpenoids were guided isolated from Daphane genus, Elephantopus scaber , and Litsea lancilimba from Global Natural Products Social (GNPS) database. 11,16,21–24 The MetGem software allows the generation of GNPS-like molecular networking and a t-SNE-based visualization of the cosine score matrix. 18,25,26 The procedure is a powerful tool for organizing hundreds of product ion spectra based on their similarity.…”

Discovery of the Caged-Vibsane Norditerpenoids with Unprecedented Chemical Architectures and Exploration of Their Various Acid Tolerances

“…Recently, we reported the eight-membered scaffold of VibDs with the assistance of GNPS tactics, which represented the discovery of a new structural subtype of VibDs (Figure. A) …”

“…Recently, we reported the eight-membered scaffold of VibDs with the assistance of GNPS tactics, which represented the discovery of a new structural subtype of VibDs (Figure . 1A). 21 As a consequence of the continuous investigation on Viburnum odoratissimum, four unique VibDs, cyclovibsanones A−D sharing the same molecular weight, were target-isolated by GNPS-guided separation (Figure 1B and Figure S1). 22−29 Although ≤113 VibDs with diverse structures have been identified so far, 1−3 represent the first examples of VibDs featuring unique [5.4.1.0 5,9 ]dodecane cores.…”