Vibrissa-related behavior in mice: transient effect of ablation of the barrel cortex

Barnéoud, Pascal; Gyger, Marcel; Andrés, F.L.; Loos, H. Van der

doi:10.1016/s0166-4328(05)80242-6

Cited by 36 publications

(25 citation statements)

References 25 publications

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“…Similar increases in BDNF hybridization were not observed in the OC. Thus, while adjacent and opposite cortical regions have been observed to undergo cortical reorganization following various injuries and are hypothesized to play a role in recovery of function (Barneoud et al, 1991; Castro-Almancos and Borrel, 1995; Dietrich et al, 1987; Dunn-Meynell and Levin, 1995), we did not observe sustained alterations in BDNF or trkB mRNA in either of these cortical regions, at least during the initial (72 h) period following FP injury.…”

Section: Discussioncontrasting

confidence: 44%

Brain-Derived Neurotrophic Factor (BDNF) and Traumatic Brain Injury (Head and Spinal)

Hicks¹

2000

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Section: Discussioncontrasting

confidence: 44%

Brain-Derived Neurotrophic Factor (BDNF) and Traumatic Brain Injury (Head and Spinal)

Hicks¹

2000

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“…Mice trained with all of their whiskers intact (MW; n ϭ 7) started [⌬M GD SW-MW ϭ 0.8 cm; t(12) ϭ 1.6; P Ͼ 0.1] and completed [⌬M GD SW-MW ϭ 0.7 cm; t(12) ϭ 0.9; P ϭ 0.372] their training with a performance similar to SW mice. However, MW mice learned the task in Ͻ40 trials [⌬M GD 1-4 ϭ 3.9 cm; t(6) ϭ 8.5; P Ͻ 0.0001], significantly faster than SW mice [F (19,190) ϭ 1.9; P ϭ 0.016]. Continued training on the task did not improve the maximum distance MW mice could gap-cross [⌬M GD 4-20 ϭ 0.2 cm; t(6) ϭ 0.3; P ϭ 0.764].…”

Section: Resultsmentioning

confidence: 99%

“…The integration of the sensory information on this array is performed in many stages of the somatosensory axis (2,3,6,7) and has been shown to modulate the expression of plasticity (13)(14)(15)(16)(17). Moreover, the cortical readout of the incoming sensory information is necessary for active sensation (18)(19)(20) and has been suggested to be depressing with increasing number of simultaneously deflected whiskers (5) and with single-whisker (SW) deflections delivered with short delays (6,8,21). Considering the predominantly suppressive interaction between different whisker deflections across the whisker pad and time, it could be argued that because of the reduction in stimulus-evoked response after the first whisker deflection, secondary whisker deflections should minimally contribute to the performance of the animal.…”

mentioning

confidence: 99%

Sensory integration across space and in time for decision making in the somatosensory system of rodents

Celikel

Sakmann

2007

Proc. Natl. Acad. Sci. U.S.A.

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Environment is represented in the brain by a neural code that is a result of the spatiotemporal pattern of incoming sensory information. Sensory neurons encode inputs across space and in time such that activity of a given cell inhibits the ability of near-simultaneously arriving sensory stimuli to excite the cell. At the behavioral level, consequences of such suppression are unknown. We investigated the contribution of spatially distributed, near-simultaneous sensory inputs to decision making in a whisker-dependent learning task. Mice learned the task with a single whisker or multiple whiskers alike. Both groups of mice had similar learning curves and final success rates. However, multiple-whisker animals had faster response times than single-whisker mice, requiring only about half the time to perform the task successfully. The results show that spatially distributed sensory inputs in a highly redundant sensory environment improve speed but not accuracy of the decisions made during simple sensory detection. Suppression of the near-simultaneous sensory inputs could, therefore, act to reduce the sensory redundancy.sensory deprivation ͉ whiskers ͉ tactile learning ͉ cortex S ensory neurons with their spatially localized, topographically organized receptive fields represent the external world in a spatiotemporally restricted manner. Although spatial encoding of the sensory information is based on the identity of the receptor being activated, the temporal encoding is a function of the timing of the receptor activation (1). During sensory stimulus perception, both processes take place concurrently to encode ''what'' information is available ''where'' within the array of sensory receptors. Previous studies in the somatosensory system showed that when multiple sensory receptors are nearsimultaneously (less than Ϸ80 ms) occupied to encode sensory information, stimulus-evoked activity is integrated sublinearly (2-9). Such nonlinear interaction between sensory inputs is not unique to the somatosensory modality (10, 11); nonetheless, its contribution to sensory perception and decision making is unknown. We have addressed these questions in the whisker system of the mouse.Whiskers with their varying length and orderly placements in rows and arcs constitute a 3D sensory array. As the animal palpates an object, located at some distance in front, whiskers contact the object in an order determined by their position within the ''whisker grid.'' Those rostral whiskers long enough to reach the object collect the sensory information before more caudally located ones with a latency (Ͻ40 ms; ref. 12) proportional to the distance between them and the speed of whisking. Although sensory integration within a row is temporal in nature, within an arc the integration is primarily spatial because of largely simultaneous deflection of whiskers in a given column. The integration of the sensory information on this array is performed in many stages of the somatosensory axis (2, 3, 6, 7) and has been shown to modulate the expression of plasticity...

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“…The effective use of mice whiskers (PN-1 Ϫ/Ϫ , n ϭ 12; PN-1 ϩ/ϩ , n ϭ 11; females, 4 -6 months of age, single housed for at least 2 months) was tested in a modified gap-crossing paradigm (Barneoud et al, 1991). All training and testing was performed blind by a single experimenter during the dark cycle under dim illumination (10 lux), and the testing was videotaped.…”

Section: Sds-page and Immunoblot Analysismentioning

confidence: 99%

Regulation of Brain Proteolytic Activity Is Necessary for theIn VivoFunction of NMDA Receptors

Kvajo¹,

Albrecht²,

Meins³

et al. 2004

J. Neurosci.

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Serine proteases are considered to be involved in plasticity-related events in the nervous system, but their in vivo targets and the importance of their control by endogenous inhibitors are still not clarified. Here, we demonstrate the crucial role of a potent serine protease inhibitor, protease nexin-1 (PN-1), in the regulation of activity-dependent brain proteolytic activity and the functioning of sensory pathways. Neuronal activity regulates the expression of PN-1, which in turn controls brain proteolytic activity. In PN-1 Ϫ/Ϫ mice, absence of PN-1 leads to increased brain proteolytic activity, which is correlated with an activity-dependent decrease in the NR1 subunit of the NMDA receptor. Correspondingly, reduced NMDA receptor signaling is detected in their barrel cortex. This is coupled to decreased sensory evoked potentials in the barrel cortex and impaired whisker-dependent sensory motor function. Thus, a tight control of serine protease activity is critical for the in vivo function of the NMDA receptors and the proper function of sensory pathways.

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Vibrissa-related behavior in mice: transient effect of ablation of the barrel cortex

Cited by 36 publications

References 25 publications

Brain-Derived Neurotrophic Factor (BDNF) and Traumatic Brain Injury (Head and Spinal)

Brain-Derived Neurotrophic Factor (BDNF) and Traumatic Brain Injury (Head and Spinal)

Sensory integration across space and in time for decision making in the somatosensory system of rodents

Regulation of Brain Proteolytic Activity Is Necessary for theIn VivoFunction of NMDA Receptors

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