Vibrational spectroscopic studies of the divalent metal ion effect on DNA structural transitions

Kornilova, S. V.; Miškovský, Pavol; Tomkova, A.; Kapinos, Larisa E.; Hackl, Elene V.; Andrushchenko, Valery; Grigoriev, D.N.; Blagoı̆, Yu. P.

doi:10.1016/s0022-2860(96)09671-8

Cited by 23 publications

(24 citation statements)

References 8 publications

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“…For all absorption bands increase in the peak intensity is accompanied by increase in the integral intensity so the strong increase of the intensity cannot also be a result of redistribution of modes in an IR spectrum. Binding of metal ions to DNA can induce dehydration of binding sites; however, dehydration of DNA itself does not lead to increase of the intensities of the absorption bands in the IR spectrum of DNA [4,42,45].…”

Section: Discussionmentioning

confidence: 99%

“…Upon the Cu 2+ ion addition the optical density of DNA solution starts to grow (Fig. 3, top, curves [2][3][4][5][6][7][8]. This is evidence of the scattering particle formation, as the random coil conformation of DNA has little scattering power compared to condensed DNA [37,38].…”

Section: Study Of Dna Interaction With Cu 2+ Ions By Light Scatteringmentioning

confidence: 99%

“…Along with water, the ions stabilise the RNA and DNA structures and regulate the transitions between the Aand B-forms of the DNA secondary structure. For example, the usual B-to A-form transition resulting from decreased humidity can be prevented by Mt 2+ ion interaction [3,4]. Many metal ions, being coenzymes, participate in mutagenesis and carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…It is also known that many antibiotics, carcinogens and so on, influence mainly through their direct interaction with DNA [5,6]. When binding to DNA, these substances are able to disrupt matrix synthesis, resulting in changes to cell functioning [4]. Divalent metal ions can simulate the action of drugs presented as mono-(for example, distamycin A) or divalent (netropsin) cations in solutions.…”

Section: Introductionmentioning

confidence: 99%

“…DNA concentration was (3.5-5) × 10 −2 M, temperature 29 • C; R = D i /D 0 , where D 0 is the optical density at maximum of an absorption band at given frequency for DNA without Mt n+ ions, D i is the same value for DNA complex with Mt n+ . Inset: Dependencies of the relative change of the intensities (R) of the absorption bands at 1090 cm −1(1,3) and 1223 cm −1 (2, 4) on the total Mt + ion concentration in aqueous solution for DNA complexes with: Na + (1, 2) and K +(3,4) ions.…”

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confidence: 99%

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DNA structural transitions induced by divalent metal ions in aqueous solutions

Hackl

Kornilova

Blagoı̆

2005

International Journal of Biological Macromolecules

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Section: Discussionmentioning

confidence: 99%

Section: Study Of Dna Interaction With Cu 2+ Ions By Light Scatteringmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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DNA structural transitions induced by divalent metal ions in aqueous solutions

Hackl

Kornilova

Blagoı̆

2005

International Journal of Biological Macromolecules

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Gas‐phase interaction between DNA and RNA bases and copper (II) ion: A density functional study

Marino

Toscano

Russo

et al. 2004

Int J of Quantum Chemistry

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ABSTRACT:This investigation, performed at Becke's three-parameter functional with Perdew-Wang correlational functional/6-311ϩG(2df,2p) level, can provide information about the geometry of all possible adducts originating from the interaction of Cu 2ϩ cation with the most stable tautomers of DNA and RNA free bases. Several attachment sites for both purine and pyrimidine bases have been taken into account. Monocoordination or bicoordination has been observed in all the obtained complexes. The copper ion (II) has the major affinity for the most stable tautomer of guanine base. We have observed that an interesting behavior occurs when the copper ion interacts with the bases in an apical approach.

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Vibrational spectra of DNA in the confined interglobular volume of photonic crystal

Boiko

Romanyuk²,

Gnatyuk

et al. 2018

J Biol Phys

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The impact of confinement of DNA molecules in a limited volume of the cavity of photonic crystals (PC) on the vibrational properties of the DNA molecule and its conformation is studied. According to our preliminary study, the aqueous shell is removed when the DNA molecules are infiltrated into the PC cavities. Raman scattering (RS) DNA marker lines showed a dramatic conformational change of DNA in the PC cavities and the appearance of new unknown conformational states. We observed the enhancement of vibrational modes of DNA in the PC in comparison with free DNA of about tenfold and the absence of vibrational modes in DNA bases in a region of 1450-1700 cm. The observed features in the RS spectra of DNA are explained by the impact of confined interglobular volume and strong localization of the electromagnetic field. Namely, FDTD simulations in linear regime demonstrate the localization of light in cavities of PC with an approximately ninefold enhancement of the electric field within the photonic stop-band, which is the main reason for RS amplification.

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Vibrational spectroscopic studies of the divalent metal ion effect on DNA structural transitions

Cited by 23 publications

References 8 publications

DNA structural transitions induced by divalent metal ions in aqueous solutions

DNA structural transitions induced by divalent metal ions in aqueous solutions

Gas‐phase interaction between DNA and RNA bases and copper (II) ion: A density functional study

Vibrational spectra of DNA in the confined interglobular volume of photonic crystal

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