Vibrational spectra, structure and antioxidant activity of gossypol imine derivatives

Design, Synthesis, and Biological Activities of Aromatic Gossypol Schiff Base Derivatives

“…It is worth mentioning that if there are multiple electron withdrawing groups on the ortho and para positions of aromatic amine, such as 2,4-dinitroaniline and 2-nitro-4-(trifluoromethyl)aniline, the corresponding Schiff base of gossypol could not be achieved but the dehydration product of gossypol, anhydrogossypol, was obtained. All of our synthetic gossypol Schiff bases exist in the enamine–enamine form , in solution as determined by 1 H NMR. For compound 5 , for example, the structure can be interpreted by the 1 H NMR spectrum (Figure ).…”

Reactivity of gossypol Schiff bases in reactions with 2,2'-diphenyl-1-picrylhydrazyl in the presence of chloride acid

“…Äîñë³äaeåííÿ àíòèðàäèêàëüíèõ âëàñòèâîñòåé ³ì³íîïîõ³äíèõ ïðèðîäíîãî ïîë³ôåíîëó, ãîñèïîëó, º àêòóàëüíîþ ³ âàaeëèâîþ çàäà÷åþ, àäaeå á³îëîã³÷í³ âëàñòèâîñò³ ïîë³ôåíîë³â áàãàòî â ÷îìó âèçíà÷àþòüñÿ çäàòí³ñòþ ³íã³áóâàòè â³ëüíîðàäè-êàëí³ ïðîöåñè îêèñíåííÿ [1][2][3]. Îäèí ³ç ðîçïîâñþäaeåíèõ ìåòîä³â îö³íþâàííÿ àíòèðàäèêàëüíèõ âëàñòèâîñòåé ïîë³ôåíîë³â ïîëÿãຠó çíåáàð-âëåíí³ ñòàá³ëüíîãî àçîòöåíòðîâàíîãî ðàäèêàëà 2,2'-äèôåí³ë-1-ï³êðèëã³äðàçèëó (DPPH) [2][3][4][5]. Àëå ó âèïàäêó ³ì³íîïîõ³äíèõ ãîñèïîëó (ÿê ³ áàãàòüîõ ³íøèõ ïîë³ôåíîë³â) ïî÷àòêîâ³ ñòà䳿 ïðîöåñó ïåðåá³ãàþòü íàñò³ëüêè øâèäêî, ùî íàâ³òü ïðè íåñòà÷³ àíòèîêñèäàíòó çà â³äíîøåííÿì äî ðàäèêàëà, ê³íåòè÷í³ êðèâ³ âäàºòüñÿ çàðåºñòðóâàòè ò³ëüêè ïðè çíà÷íèõ ñòóïåíÿõ ïåðåòâîðåííÿ [5,6].…”

“…Îäèí ³ç ðîçïîâñþäaeåíèõ ìåòîä³â îö³íþâàííÿ àíòèðàäèêàëüíèõ âëàñòèâîñòåé ïîë³ôåíîë³â ïîëÿãຠó çíåáàð-âëåíí³ ñòàá³ëüíîãî àçîòöåíòðîâàíîãî ðàäèêàëà 2,2'-äèôåí³ë-1-ï³êðèëã³äðàçèëó (DPPH) [2][3][4][5]. Àëå ó âèïàäêó ³ì³íîïîõ³äíèõ ãîñèïîëó (ÿê ³ áàãàòüîõ ³íøèõ ïîë³ôåíîë³â) ïî÷àòêîâ³ ñòà䳿 ïðîöåñó ïåðåá³ãàþòü íàñò³ëüêè øâèäêî, ùî íàâ³òü ïðè íåñòà÷³ àíòèîêñèäàíòó çà â³äíîøåííÿì äî ðàäèêàëà, ê³íåòè÷í³ êðèâ³ âäàºòüñÿ çàðåºñòðóâàòè ò³ëüêè ïðè çíà÷íèõ ñòóïåíÿõ ïåðåòâîðåííÿ [5,6]. Öå íå äîçâîëÿº îö³íèòè ðåàêö³éíó çäàòí³ñòü ³ì³íîïîõ³äíèõ ãîñèïîëó ñòîñîâíî DPPH áåç çàñòîñîâóâàííÿ îáëàäíàííÿ äëÿ äîñë³äaeåííÿ ê³íå-òèêè øâèäêèõ ðåàêö³é.…”

“…Ðåçóëüòàòè ³ îáãîâîðåííÿ Ðàí³øå íàìè ïîêàçàíî, ùî ³ì³íîïîõ³äí³ ãîñèïîëó º åôåêòèâíèìè àíòèðàäèêàëüíèìè àãåíòàìè ñòîñîâíî DPPH [3,5,6]. Äëÿ õàðàêòåðèñòèêè ðåàêö³¿ öèõ ñïîëóê ç DPPH âèêîðèñòàíî íèçêó ïàðàìåòð³â: ÅÑ 50 (êîíöåíòðàö³ÿ àíòèîêñèäàíòó, ùî íåîáõ³äíà äëÿ çìåíøåííÿ êîí-öåíòðàö³¿ ðàäèêàëà íà 50%), ñòåõ³îìåòðè÷í³ êî-åô³ö³ºíòè, VCEAC (åêâ³âàëåíò àíòèîêñèäàíòíî¿ ºìíîñò³ â ïåðåðàõóíêó íà àñêîðá³íîâó êèñëîòó), TEAC (åêâ³âàëåíò àíòèîêñèäàíòíî¿ ºìíîñò³ â ïåðåðàõóíêó íà òðîëîêñ).…”

DFT calculations, spectroscopy and antioxidant activity studies on (E)-2-nitro-4-[(phenylimino)methyl]phenol

“…These papers contain such subject as synthesis, coordination chemistry application, crystal structure determination, ab initio and DFT calculations, vibrational characteristics, antioxidant, antibacterial activities, the free radical scavenging activities and non-linear optic properties [19][20][21][22][23][24][25][26][27][28][29][30][31].…”