Vibrational spectra and normal coordinate treatment of N,N-dimethyIthioacetamide

Reddy, T. Bhupal; Ramanarao, G.; Chalapathi, V. Venkata

doi:10.1007/bf02841326

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…ATR-FT-IR spectroscopic measurements performed on the washed and dried reaction products obtained from the mechanochemical synthesis also confirmed the formation of acrylate-based polymers. The characteristic vibrational band assignment of the key components of the reaction mixture, namely the two functional monomers, MAA and 2-TFMAA, as well as the employed cross-linker, MBA, was performed based on literature data [32]. As expected, the spectral profiles of the MIPs and NIPs were identical (Figure S2, ESI), as both types of polymers were subjected to the same (template) washing procedure.…”

Section: Synthesis and Characterization Of Polymersmentioning

confidence: 82%

“…As major component, most of the strong characteristic vibrational bands of the pure cross-linker (MBA) were also found in the spectra of the resulting polymeric products. These bands were slightly widened due the lengthening of the polymeric chain and their involvement in additional hydrogen bonding, such as the C=O stretching mode (Amide I band, 1650 cm −1 ), N-H deformation (amide II band, 1535 cm −1 ), N-H stretching (3305 cm −1 ), and C-N stretching mode (amide III band, 1301 cm −1 ) [32,35]. However, the full suppression of the vinylic group's stretching mode (~1620-1630 cm −1 ) present in the spectra of the pure cross-linker (1621 cm −1 for MBA) and functional monomer(s) (1630 cm −1 for MAA; 1632 cm −1 for 2-TFMAA) is a strong indication of the polymeric network's formation [32,36].…”

Section: Synthesis and Characterization Of Polymersmentioning

confidence: 99%

“…These bands were slightly widened due the lengthening of the polymeric chain and their involvement in additional hydrogen bonding, such as the C=O stretching mode (Amide I band, 1650 cm −1 ), N-H deformation (amide II band, 1535 cm −1 ), N-H stretching (3305 cm −1 ), and C-N stretching mode (amide III band, 1301 cm −1 ) [32,35]. However, the full suppression of the vinylic group's stretching mode (~1620-1630 cm −1 ) present in the spectra of the pure cross-linker (1621 cm −1 for MBA) and functional monomer(s) (1630 cm −1 for MAA; 1632 cm −1 for 2-TFMAA) is a strong indication of the polymeric network's formation [32,36]. Particularities in the IR spectral profiles of the imprinted and non-imprinted M1 and M2 polymers were related to the type of functional monomer employed (MAA and 2-TFMAA) and were identified at ~1180 cm −1 due to the intense stretching mode of the highly polar C-F bond (Figure S2E, ESI) [37].…”

Section: Synthesis and Characterization Of Polymersmentioning

confidence: 99%

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Unlocking New Avenues: Solid-State Synthesis of Molecularly Imprinted Polymers

Iacob,

Bodoki,

Da Costa Carvalho

et al. 2024

IJMS

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Molecularly imprinted polymers (MIPs) are established artificial molecular recognition platforms with tailored selectivity towards a target molecule, whose synthesis and functionality are highly influenced by the nature of the solvent employed in their synthesis. Steps towards the “greenification” of molecular imprinting technology (MIT) has already been initiated by the elaboration of green MIT principles; developing MIPs in a solvent-free environment may not only offer an eco-friendly alternative, but could also significantly influence the affinity and expected selectivity of the resulting binding sites. In the current study the first solvent-free mechanochemical synthesis of MIPs via liquid-assisted grinding (LAG) is reported. The successful synthesis of the imprinted polymer was functionally demonstrated by measuring its template rebinding capacity and the selectivity of the molecular recognition process in comparison with the ones obtained by the conventional, non-covalent molecular imprinting process in liquid media. The results demonstrated similar binding capacities towards the template molecule and superior chemoselectivity compared to the solution-based MIP synthesis method. The adoption of green chemistry principles with all their inherent advantages in the synthesis of MIPs may not only be able to alleviate the potential environmental and health concerns associated with their analytical (e.g., selective adsorbents) and biomedical (e.g., drug carriers or reservoirs) applications, but might also offer a conceptual change in molecular imprinting technology.

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Section: Synthesis and Characterization Of Polymersmentioning

confidence: 82%

Section: Synthesis and Characterization Of Polymersmentioning

confidence: 99%

Section: Synthesis and Characterization Of Polymersmentioning

confidence: 99%

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Unlocking New Avenues: Solid-State Synthesis of Molecularly Imprinted Polymers

Iacob,

Bodoki,

Da Costa Carvalho

et al. 2024

IJMS

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“…The existence of the C-N functional group in the structure of MBA was confirmed by a sharp peak at wavenumber 1304.6 cm −1 . In addition, the absorption band at 670.9 cm −1 was seen due to the in-plane bending vibrations of the amide (O=C-N) group [22].…”

Section: Ftir Analysis Of Topical Hydrogel Patchmentioning

confidence: 99%

Flexible Topical Hydrogel Patch Loaded with Antimicrobial Drug for Accelerated Wound Healing

Saeed

Barkat

Ashraf

et al. 2023

Gels

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A hydrogel topical patch of neomycin was developed by using sodium alginate (SA) and hydroxyethylcellulose (HEC) as polymers. Free radical polymerization in an aqueous medium was initiated by using acrylic acid (AA) and N,N′-methylenebisacrylamide (MBA). Prepared hydrogels were characterized for pH sensitivity and sol–gel analysis. In addition, the effect of reactant contents on the developed formulation was evaluated by swelling behavior. SEM assay showed the rough structure of the hydrogel-based polymeric matrix, which directly enhances the ability to uptake fluid. FTIR spectra revealed the formation of a new polymeric network between reactant contents. TGA and DSC verified that fabricated polymeric patches were more thermodynamically stable than pure components. Gel fractions increased with increases in polymer, monomer, and cross-linker contents. The swelling study showed the pH-dependent swelling behavior of patches at pH 5.5, 6.5, and 7.4. The release pattern of the drug followed zero-order kinetics, with diffusion-controlled drug release patterns according to the Korsmeyer–Peppas (KP) model. Ex vivo studies across excised rabbit skin verified the drug retention in the skin layers. The hydrogel patch effectively healed the wounds produced on the rabbit skin, whereas the formulation showed no sign of irritation on intact skin. Therefore, neomycin hydrogel patches can be a potential candidate for controlled delivery for efficient wound healing.

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