Vibrational analysis of ring-opening polymerizations of glycolide, L-lactide and D,L-lactide

Kister, G; Cassanas, G.; Fabregue, E.; Bardet, L.

doi:10.1016/0014-3057(92)90218-q

Cited by 21 publications

(21 citation statements)

References 10 publications

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“…2 17,18 or PLA 50 plate, confirming the amorphous nature of these samples. 15 -18 For the PLA 50 plate, the polymerization degree and the eventual presence of residual monomer (D,L-lactide) and oligomers were spectroscopically evaluated; 15 the absence in its Raman spectrum of the bands at 830 cm 1 ( C-COOH stretching mode in oligomers and lactic acid), 11,25 660 and 420 cm 1 (υring bending modes of D,L-lactide), 10 480 cm 1 (υC O in-plane bending mode of D,L-lactide) 10 revealed that polymerization had efficiently taken place, producing a biomedical device with high molecular weight and therefore adequate physicomechanical properties.…”

Section: Pla Homopolymers Vibrational Characterizationmentioning

confidence: 99%

Vibrational spectroscopy of polymeric biomaterials

Taddei

Tinti

Fini

2001

J Raman Spectroscopy

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This review highlights the potential of vibrational spectroscopy for investigating the molecular structure of some polymeric materials used in biomedical applications in relation to their biocompatibility. Many types of polymers are used for biomedical purposes; depending on the application, bioresorbable or non-bioresorbable (semi-crystalline or amorphous) polymers are used. Among bioresorbable polymers, we focused on homopolymers and copolymers based on poly(lactic acid), poly(glycolic acid) and poly(ecaprolactone). Being a nondestructive technique, Raman spectroscopy proved particularly suitable for evaluating the molecular structure and crystallinity of bioresorbable polymers and their degradation products. For various biomedical applications, non-degradable semi-crystalline polymers have been widely employed; in this class of polymers, we concentrated on ultra-high molecular weight polyethylene (UHMWPE) used in orthopaedic implants (total hip and knee joints). Vibrational spectroscopy appeared particularly suitable in studying the oxidation and crystallinity of UHMWPE.

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Section: Pla Homopolymers Vibrational Characterizationmentioning

confidence: 99%

Vibrational spectroscopy of polymeric biomaterials

Taddei

Tinti

Fini

2001

J Raman Spectroscopy

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“…Equation (8) implies that there is a linear relationship between the inverse of the polymer's absorbance ratio in the mixture (…”

Section: Synthesis Of the Star-shaped Plamentioning

confidence: 99%

“…PLA samples were dissolved in HPLC grade THF (from Chromservis Prague, Czech republic) at concentrations in the range of 8. [8][9][10][11][12][13][14][15][16][17][18][19].05 mg/mL and filtered during injection with 0.22 μm PTFE membrane filter. The flow rate of the mobile phase in the system was 1 mL/min with 20 μL injected samples that were recorded at 220 nm for 14 min.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

“…[9,10] Therefore, ROP of lactide monomers, requiring no water removal and yielding high-molecular weight PLA, has clear advantages. [8] The driving force for ROP is the relief of conformation strains in the cyclic monomers and thus thermodynamically favorable as it results in reducing the total free energy of the molecule. [11] For ROP to be successful, a catalyst is required.…”

Section: Introductionmentioning

confidence: 99%

“…[7] Polymerization of PLA can basically be achieved by two ways: polycondensation (step-growth) reaction of lactic acid, and ring-opening polymerization (ROP) of lactide monomers. [8] During step-growth polymerization, challenges include the removal of water as a side-product. This type of polymerization leads to products with low molecular weight.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Solution-based synthesis of a four-arm star-shaped poly(L-lactide)

Eldessouki

Buschle‐Diller

Gowayed

2016

Designed Monomers and Polymers

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The mechanical properties of biocompatible poly(L-lactide) (PLA) could be dramatically enhanced by cross-linking and interesting network structures might be achieved via the formation of branched and star-shaped structures prior to such cross-linking. However, the synthesis of a four-armed starshaped PLA is limited to bulk melt polymerization at relatively high temperatures that may degrade the monomer and render the reaction kinetics difficult to control. In this work, a solution-based polymerization approach is introduced with dimethylformamide as the solvent for the initiator and all other reactants. Varying the reactant concentrations and reaction temperature, four-arm PLA star structures were produced in solution and their properties were analyzed. The progress of the polymerization reaction was studied using the 1 H NMR and Fourier transform infrared spectroscopy. The quantitative evaluation of the monomer conversion was discussed on theoretical basis. The thermal properties and the crystallinity of the product polymers were evaluated using differential scanning calorimetry. Results indicate polymerization and cross-linking of the four-armed PLA were successful. The introduced solution-based method could open venues for better controlled and more economic reactions of star-shaped and cross-linked PLA.

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Fabrication of Architectured Biomaterials by Multilayer Co‐Extrusion and Additive Manufacturing

Vellayappan

Duarte

Sollogoub

et al. 2023

Adv Funct Materials

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Tissue engineering benefits from advances in 3D printing and multimaterial assembly to attain certain functional benefits over existing man-made materials. Multilayered tissue engineering constructs might unlock a unique combination of properties, but their fabrication remains challenging. Herein, a facile process is reported to manufacture biomaterials with an engineered multilayer architecture, via a combination of co-extrusion and 3D printing. Polymer filaments containing 5, 17, or 129 alternating layers of poly(lactic acid)/thermoplastic polyurethane (PLA/TPU) are produced, and explored for their use in fused deposition modeling (FDM) to fabricate scaffolds for cardiomyocyte culture. The coextruded filaments exhibit a layered architecture in their cross-section with a continuous interface, and the integrity and alignment of the layers are preserved after 3D printing. The 17 alternating layers PLA/TPU composites exhibit excellent mechanical properties. It is envisaged that the multilayered architecture of the fabricated scaffolds can be beneficial for aligning cardiomyocytes in culture. It is found that the 17 alternating layers PLA/ TPU significantly improve cardiomyocyte morphology and functionality compared to single phase materials. It is believed that this biomaterials fabrication scheme, combining a top-down and bottom-up approach, offers tremendous flexibility in producing a broad class of novel-architectured materials with tunable structural design for tissue engineering applications and beyond.

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Vibrational analysis of ring-opening polymerizations of glycolide, L-lactide and D,L-lactide

Cited by 21 publications

References 10 publications

Vibrational spectroscopy of polymeric biomaterials

Vibrational spectroscopy of polymeric biomaterials

Solution-based synthesis of a four-arm star-shaped poly(L-lactide)

Fabrication of Architectured Biomaterials by Multilayer Co‐Extrusion and Additive Manufacturing

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