Vibration threshold in non-diabetic subjects

Nolte, Svea; Londen, Marco van; Elting, Jan Willem J.; Greef, Bianca T A de; Kuks, Jan B. M.; Faber, Catharina G.; Nolte, Ilja M.; Groen, Rob J. M.; Bakker, Stephan J. L.; Groothof, Dion; Lesman‐Leegte, Ivonne; Berger, Stefan P.; Drost, Gea

doi:10.1371/journal.pone.0237733

Cited by 6 publications

(7 citation statements)

References 31 publications

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“…This study also showed a similar result. Previous studies have reported the correlation between height and VPT in non-diabetic subjects ( 20 ) and patients with diabetes ( 11 ) and no similar correlation was found in our gout population. A significant association was also found between ESR (inflammatory markers of disease activity) and abnormal VPT in this study.…”

Section: Discussioncontrasting

confidence: 76%

“…However, up to now, no study specifically investigated associated factors with VPT in patients with gout. A variety of factors are related to VPT and the correlation between age and VPT has been widely reported, both in the general population ( 20 ) and in patients with diabetes ( 11 ). Similarly, this study also confirmed the independent correlation between abnormal VPT and age in patients with gout.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout

Guo

Liang

et al. 2022

Front. Neurol.

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ObjectivePeripheral neuropathies (PNs) are a group of disorders that affect the peripheral nervous system. PN in gout has been scarcely described. This study is conducted to determine the prevalence and related risk factors of PN, as assessed by vibration perception threshold (VPT) in patients with gout.MethodsA total of 442 patients were included in the cross-sectional study. The VPT values were measured by using the Biothesiometer sensory quantitative tester on each patient. The VPT value of either limb higher than 15 V was considered abnormal and is considered to have PN. The univariate and multivariate logistic regression models were used to identify risk factors for PN in patients with gout.ResultsWe included 442 patients with gout, 97.5% men, 26.9% tophaceous gout, mean age 45.5 ± 15.2 years, and 7.4 ± 4.6 years of disease duration. The prevalence of PN in patients with gout was 11.1%. Patients in the abnormal VPT group were older, had a longer gout duration, and had significantly higher levels of waist circumference, waist-to-hip ratio, systolic blood pressure (SBP), and erythrocyte sedimentation rate (ESR), as compared to patients in the normal vibration group (P < 0.05). The univariate logistic regression analysis demonstrated that there was a significant association between abnormal VPT and age, duration of gout, SBP, C-reactive protein, ESR, presence of tophi, and estimated glomerular filtration rate (eGFR) in all the subjects (P < 0.05). The multivariate logistic regression analysis indicated that age (odds ratio, 1.094) and presence of tophi (odds ratio, 1.048) were independent risk factors for PN in patients with gout.ConclusionThe abnormal VPT was significantly correlated with age and presence of tophi in patients with gout and the VPT level may be useful as a screening tool for assessment of PN in gout.

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Section: Discussioncontrasting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout

Guo

Liang

et al. 2022

Front. Neurol.

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“…While the possible causes of these changes are manifold, including repeated trauma, focal nerve entrapment, and ischemia, the normal process of biological aging is thought to be an important contributing factor. The most suggestive evidence of central-peripheral distal axonopathy is the progressive increase in vibratory threshold with age, more in the lower limb (great toe) than in the upper limb (finger) [ 154 , 155 , 156 , 157 , 158 , 159 , 160 ]. Vibration perception also decreases with body height, which is consistent with a length-dependent axonopathy [ 160 ].…”

Section: Relationship To Neuropathies Of Endogenous Originmentioning

confidence: 99%

The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin

Spencer

Chen

2021

Toxics

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The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with old age. These conditions may be linked by metabolites that adduct and cross-link neuroproteins required for the maintenance of axonal transport and nerve fiber integrity in the peripheral and central nervous system.

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“…It can be used as a tool for research into occupational health to screen workers at workplace for peripheral neuropathy caused by direct vibration or toxic substances [7,8]. The VPT is an effective predictor of the risk of trophic ulceration of the feet and risk of amputation in diabetic patients and, therefore can be used to target foot-care education as a preventive measure [9][10][11][12][13]. The VPT is also widely applied in community-based research, occupational health screening in industries and ambulatory clinics [5].…”

Section: Introductionmentioning

confidence: 99%

Assessing the vibration perception threshold in a community sample of adult Ghanaians

Djankpa,

Amoah,

Adzaku

et al. 2023

PLoS ONE

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Background The vibration perception threshold (VPT) helps evaluate human somatosensory function and diagnose peripheral neuropathy. To optimize its use as a primary neurologic tool, it is imperative to establish its typical values in healthy subjects and assess the factors affecting its variability in an individual to ensure consistency in its application. Methods Demographic data and a brief medical history were collected from 391 non-diabetic adults aged 30–80 at Kpone-on-Sea in Ghana. The VPT was measured at the tip of the big toe, the medial malleolus, the tip of the middle finger, and the head of the ulna of each participant using a Horwell Neurothesiometer. The variability of VPT was assessed vis-à-vis the following factors: gender, age, fasting plasma sugar and body mass index. Results The mean age of participants was 48.4 ± 0.7 years, and the female-to-male ratio was 1.46. The overall VPT values ranged from 5.74 ± 0.14 volts to 8.55 ± 0.18 volts in the lower limbs and 3.61 ± 0.06 volts to 5.00 ± 0.08 volts in the upper limbs. Age was found to be the only factor that could predict VPT for both the lower and upper limbs (P < 0.001). One-Way Analysis of Variance with Tukey’s posthoc showed that the VPT in the feet was significantly higher than that in the hands. Conclusions Generally, the VPT was high on proximal sites and low on distal sites indicating that the vibration sensation increased from proximal to distal direction. Therefore, distal areas should be used for VPT testing with a Neurothesiomer. Age was found to be the only factor that affected VPT variability. Hence, the practical application of VPT will require age-specific reference ranges to cater for older adults.

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Vibration threshold in non-diabetic subjects

Cited by 6 publications

References 31 publications

Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout

Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout

The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin

Assessing the vibration perception threshold in a community sample of adult Ghanaians

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