Vibration of osteoblastic cells using a novel motion‐control platform does not acutely alter cytosolic calcium, but desensitizes subsequent responses to extracellular ATP
Abstract:Low‐magnitude high‐frequency mechanical vibration induces biological responses in many tissues. Like many cell types, osteoblasts respond rapidly to certain forms of mechanostimulation, such as fluid shear, with transient elevation in the concentration of cytosolic free calcium ([Ca2+]i). However, it is not known whether vibration of osteoblastic cells also induces acute elevation in [Ca2+]i. To address this question, we built a platform for vibrating live cells that is compatible with microscopy and microspec… Show more
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