Viability of permanent PMMA spacer with combined free fasciocutaneous tissue transfer for failed charcot reconstruction: A 38 month prospective case report

Abstract

HighlightsThis case report demonstrates the long term viability and utility of the use of permanent cement spacers when combined with free tissue transfer for closure of complex diabetic foot wounds.Charcot Neuroarthropathy often requires osseous reconstruction, which can be complicated with osteomyelitis and hardware infection.This case is an example of a multidisciplinary team approach to limb salvage with successful long term outcome; a plantigrade stable functional foot in an ambulatory highly active patient.Follow up time since initial intervention was 38 months.

Osteogenic and antibacterial dual functions of a novel levofloxacin loaded mesoporous silica microspheres/nano-hydroxyapatite/polyurethane composite scaffold

“…Although antibiotic-loaded polymethylmethacrylate (PMMA) is the gold standard biomaterial against osteomyelitism, 4 , 5 , 6 , 7 it bears serious shortcomings including limited and irregular antibiotic release, incompatibility with many types of antibiotics, demand a second surgery to remove and lack of bone regeneration or conduction. 8 , 9 Thus, design and construction of alternative, biodegradable materials to deliver antibiotics locally and promote osteogenesis have been given high priority.…”