Viability criteria assessment during liver machine perfusion

Brüggenwirth, Isabel M A; Meijer, Vincent E de; Porte, Robert J.; Martins, Paulo N.

doi:10.1038/s41587-020-0720-z

Cited by 38 publications

(51 citation statements)

References 21 publications

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“…Two strategies appear. First, identify a large number of unspecific parameters and thresholds, requiring artificial intelligence to calculate sort of score points to decide, if a single organ could be used for transplantation [52]. Or second, an easy, cheap, and more precise approach using a few single tests of biomolecules, released from mitochondrial complex I, the key site, where the IRI cascade initiates [40,53,54].…”

Section: Figurementioning

confidence: 99%

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Viability Assessment in Liver Transplantation—What Is the Impact of Dynamic Organ Preservation?

et al. 2021

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Based on the continuous increase of donor risk, with a majority of organs classified as marginal, quality assessment and prediction of liver function is of utmost importance. This is also caused by the notoriously lack of effective replacement of a failing liver by a device or intensive care treatment. While various parameters of liver function and injury are well-known from clinical practice, the majority of specific tests require prolonged diagnostic time and are more difficult to assess ex situ. In addition, viability assessment of procured organs needs time, because the development of the full picture of cellular injury and the initiation of repair processes depends on metabolic active tissue and reoxygenation with full blood over several hours or days. Measuring injury during cold storage preservation is therefore unlikely to predict the viability after transplantation. In contrast, dynamic organ preservation strategies offer a great opportunity to assess organs before implantation through analysis of recirculating perfusates, bile and perfused liver tissue. Accordingly, several parameters targeting hepatocyte or cholangiocyte function or metabolism have been recently suggested as potential viability tests before organ transplantation. We summarize here a current status of respective machine perfusion tests, and report their clinical relevance.

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Section: Figurementioning

confidence: 99%

“…Multiple parameters to assess viability during machine perfusion have been suggested within the last 5 years. Today there is no widely accepted marker, which is reliable to provide enough confidence to accept a liver [52]. Two potential strategies are available.…”

Section: Summary and Future Perspectivementioning

confidence: 99%

Viability Assessment in Liver Transplantation—What Is the Impact of Dynamic Organ Preservation?

et al. 2021

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“…This highlights that hepatocellular viability is likely physiologically separate from biliary/cholangiocyte viability and should be included in future trials to check viability. ( 3 )…”

Section: Author/center Publication No Of Patients Declined Livers Group Vs Standard Allocation Country/rate Of Decline Outcomesmentioning

confidence: 99%

A Call for Randomization in Clinical Trials of Liver Machine Perfusion Preservation

Martins

Clavien²,

Jalan

et al. 2021

Hepatology

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“…This project awarded him and his mentees several awards and impactful articles. [4][5][6] Last but not least, Dr. Martins has championed diversity/ equity efforts at local and national levels. He has dedicated efforts to increasing diversity by actively participating in diversity/minorities committees of the United Network of Organ Sharing (UNOS), American Society of Transplant Surgeons.…”

Section: E D I T O R I a L Paulo Martins To Serve As An Associate Edimentioning

confidence: 99%

“…His team was the first to use machine preservation as a platform for gene silencing using siRNAs to alleviate organ ischemia reperfusion injury. This project awarded him and his mentees several awards and impactful articles 4‐6 …”

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confidence: 99%

Paulo Martins to serve as an Associate Editor of Artificial Organs

Tchantchaleishvili

2021

Artificial Organs

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Viability criteria assessment during liver machine perfusion

Cited by 38 publications

References 21 publications

Viability Assessment in Liver Transplantation—What Is the Impact of Dynamic Organ Preservation?

Viability Assessment in Liver Transplantation—What Is the Impact of Dynamic Organ Preservation?

A Call for Randomization in Clinical Trials of Liver Machine Perfusion Preservation

Paulo Martins to serve as an Associate Editor of Artificial Organs

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