Viability assessment of non-heart-beating donor kidneys by alpha glutathione S-transferase in the machine perfusate

Kievit, J.K.; Oomen, A.P.A.; Janssen, Marie P.; Kreel, B.K. van; Heineman, Erik; Kootstra, G.

doi:10.1016/s0041-1345(96)00603-3

Cited by 29 publications

(24 citation statements)

References 6 publications

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“…12,[24][25][26][27][28] Evidence remains controversial and based largely on animal models. Biomarkers most likely will be incorporated in clinical viability scores, rather than be used in isolation.…”

Section: Machine Perfusate Biomarkersmentioning

confidence: 99%

“…6,20 During MP, α-glutathione levels correlate with warm ischemia time; with prolonged ischemia being associated with higher levels. [26][27] Similarly, levels are lower in functioning, compared to nonfunctioning, grafts from NHBDs. [26][27] Further research into the functioning NHBD kidney group has demonstrated that GST levels are significantly higher at the end of MP in kidneys with DGF compared with kidneys with immediate function.…”

Section: Glutathione S-transferasementioning

confidence: 99%

“…[26][27] Similarly, levels are lower in functioning, compared to nonfunctioning, grafts from NHBDs. [26][27] Further research into the functioning NHBD kidney group has demonstrated that GST levels are significantly higher at the end of MP in kidneys with DGF compared with kidneys with immediate function. 6 Moers and associates, were the first to show that GST levels, although related to warm ischemia time, 6,26 also represent an independent risk factor for DGF.…”

Section: Glutathione S-transferasementioning

confidence: 99%

“…[26][27] Further research into the functioning NHBD kidney group has demonstrated that GST levels are significantly higher at the end of MP in kidneys with DGF compared with kidneys with immediate function. 6 Moers and associates, were the first to show that GST levels, although related to warm ischemia time, 6,26 also represent an independent risk factor for DGF. 6 Other research has shown isolated cases of high GST levels occurring in functioning NHBD grafts, showing that GST levels cannot necessarily be considered in isolation.…”

Section: Glutathione S-transferasementioning

confidence: 99%

See 3 more Smart Citations

Advances in Machine Perfusion Graft Viability Assessment in Kidney, Liver, Pancreas, Lung, and Heart Transplant

Balfoussia

Yerrakalva²,

Hamaoui³

et al. 2012

Exp Clin Transplant

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Section: Machine Perfusate Biomarkersmentioning

confidence: 99%

Section: Glutathione S-transferasementioning

confidence: 99%

Section: Glutathione S-transferasementioning

confidence: 99%

Section: Glutathione S-transferasementioning

confidence: 99%

See 2 more Smart Citations

Advances in Machine Perfusion Graft Viability Assessment in Kidney, Liver, Pancreas, Lung, and Heart Transplant

Balfoussia

Yerrakalva²,

Hamaoui³

et al. 2012

Exp Clin Transplant

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“…However, over the past decade, the growing disparity in supply and demand of organs and the use of more marginal kidneys from Non Heart Beating Donors (NHBD) have renewed interest in pulsatile preservation systems. In Europe, these systems have been used for testing the quality of kidneys from such donors [9].…”

Section: Introductionmentioning

confidence: 99%

Machine perfusion for kidneys: how to do it at minimal cost

Balupuri¹,

Strong²,

Hoernich³

et al. 2001

Transplant International

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Due to a shortage of organs for transplantation, many centres use marginal grafts to increase their donor pool. As kidneys from non-heart-beating donors (NHBD) have sustained initial ischaemic damage, their viability is difficult to predict. Hypothermic pulsatile perfusion has not only been used to improve the condition of such grafts, but also allows viability assessment. Suitable systems are becoming more readily available, but they are expensive. We have used existing dialysis equipment with modified sterilised inserts to create a pulsatile hypothermic perfusion system. With this system, 41 NHBD kidneys were perfused for up to 8 h; their intravascular renal resistance (IRVR), flow characteristics as well as glutathione S transferase (GST) measurements were performed to assess viability. This hypothermic pulsatile perfusion system is now an integral component of our NHBD programme.

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Kidney preservation in the next millenium

Stubenitsky¹,

Booster²,

Nederstigt³

et al. 1999

Transplant International

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For the past decades, severe hypothermia has represented the foundation of organ preservation in clinical transplantation. Beneficial as hypothermia has proven to be in preserving grafts from heart-beating donors, hypothermia does not seem to provide the window necessary for the prospective evaluation of organ function. With the increasing use of non-heart-beating donors, it is logical to propose that if organs are to be evaluated prospectively, it will be necessary to preserve them at warmer temperatures. Since both glomerular and tubular functions are inhibited at temperatures below 18 degrees C, such a goal will necessitate organ preservation at a temperature above 20 degrees C. The principle of preservation at warmer temperatures is not new, but with future developments and approaches, successful realization appears within reach. In this overview, a brief history of previous attempts at warm preservation, in the context of the current status of kidney preservation, is presented. Future developments and approaches, with the potential for prospective testing of the function and enhanced resistance to ischemic damage, will be discussed.

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Viability assessment of non-heart-beating donor kidneys by alpha glutathione S-transferase in the machine perfusate

Cited by 29 publications

References 6 publications

Advances in Machine Perfusion Graft Viability Assessment in Kidney, Liver, Pancreas, Lung, and Heart Transplant

Advances in Machine Perfusion Graft Viability Assessment in Kidney, Liver, Pancreas, Lung, and Heart Transplant

Machine perfusion for kidneys: how to do it at minimal cost

Kidney preservation in the next millenium

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