Viability and function of red blood cell concentrates stored at 4 degrees C for 35 days in CPDA‐1, CPDA‐2, or CPDA‐3

Valeri, C. R.; Valeri, D A; Gray, Alan; Melaragno, A J; Dennis, Richard C.; Emerson, Charles P.

doi:10.1046/j.1537-2995.1982.22382224943.x

Cited by 48 publications

(27 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Levels of 2,3-DPG seem to fall more quickly over the first 10-14 days in the heparin/CPDA-1 stored RCC, but concentrations did not differ signif icantly from the routine preparation at any point in time. Our data are similar to those published for CPDA-1 RCC [9,11].…”

Section: Discussionsupporting

confidence: 90%

“…ATP should not fall below 40% of initial value. Both CPDA-1 and heparin/ CPDA-1-stored RCC showed more favor able ATP levels over the entire period of stor age compared to the results of Valeri et al [9].…”

Section: Discussioncontrasting

confidence: 54%

“…Analysis of hematology pa rameters were found to give equal results both for routine and modified RCC. Mean plasma hemoglobin is slightly higher in both groups compared to data reported by Valeri et al [9] and Zuck et al [10]. Levels of 2,3-DPG seem to fall more quickly over the first 10-14 days in the heparin/CPDA-1 stored RCC, but concentrations did not differ signif icantly from the routine preparation at any point in time.…”

Section: Discussioncontrasting

confidence: 41%

See 2 more Smart Citations

Metabolic Aspects and Viability of Heparin/CPDA-1-Stored Red Cell Concentrate as a By-Product of a High-Yield Factor VIII Production Method

Jonge¹,

Sibinga²,

Das³

1983

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

As a by-product of a new high-yield method of production of freeze-dried factor VIII, red cell concentrate (RCC) containing a small amount of heparin besides CPDA-1 was studied. Compared to CPDA-1-stored RCC no difference was found in hematology parameters and 2,3-DPG levels during 28 days storage. Although still in the normal range for transfusion, ATP levels were significantly lower compared to CPDA-1-stored RCC after 30 days shelf life. A survival study with ⁵¹Cr-labelled red cells showed good recovery and normal red cell half-life. Rapid transfusion of heparin/CPDA-1 RCC in 6 volunteers did not have any effect on aPTT. Heparin could not be detected in posttransfusion plasma samples.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 54%

Section: Discussioncontrasting

confidence: 41%

See 1 more Smart Citation

Metabolic Aspects and Viability of Heparin/CPDA-1-Stored Red Cell Concentrate as a By-Product of a High-Yield Factor VIII Production Method

Jonge¹,

Sibinga²,

Das³

1983

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

show abstract

“…Intraerythrocytic ATP increased during the 1st week of storage; from the 1st to the 6th week, the ATP level be metabolized by erythrocytes after its transformation into D-fructose. In our trial, packed RBC resuspended in PAGGS-sorbitol solution show an efficiency in glucose uptake which is comparable to that of whole blood in CPDA-1 [2][3][4]14], A remarkable increase in intracellular ATP at time 0, when compared to in vivo values, is evident: this is probably due to the effect of acid preservation on the glycolysis of erythrocytes and to direct uptake of adenine from PAGGS-sorbitol. ATP content increased further to reach a peak level on the 7th day of storage and was reduced to a concentration slightly lower than the initial in vivo values only after 6 weeks.…”

Section: Resultsmentioning

confidence: 52%

“…Packed red blood cells (RBC), prepared from whole blood by removal of plasma, undergo a progressive meta bolic and functional deterioration which is faster than when the RBC are resuspended in a preservative medium [1,2]. An RBC-resuspending medium should have the same functional capability as plasma stored in CPDA-1.…”

Section: Introductionmentioning

confidence: 99%

Biochemistry of Packed Red Blood Cell Concentrates Stored in PAGGS-Sorbitol Solution for 42 Days

Fagiolo¹,

Littaru²,

Lippa³

et al. 1987

Vox Sanguinis

View full text Add to dashboard Cite

We investigated metabolic, blood gas and acid-base balance modifications of erythrocyte concentrates resuspended in PAGGS-sorbitol solution during 6 weeks of storage. Glucose utilization was impaired during the last 2 weeks, while the intraerythrocytic ATP level decreased only 50% from the 1st to the 6th week. The K^+ and Hb concentration in the medium showed a progressive increase which was more pronounced during the last 2 weeks. The decrease in pH progressed to reach 6.27 at the 6th week of storage. Intraerythrocytic 2,3-DPG dropped rapidly in the course of the 1st week and the percentage of oxyhemoglobin showed a remarkable increase after the 1st week (90%). Our data suggest that erythrocyte concentrates in PAGGS-sorbitol should be transfused, for optimal efficacy, within 4 weeks.

show abstract

Gewinnung, Konservierung, Lagerung von Transfusionsblut

Stangel¹

1996

Transfusionsmedizin

View full text Add to dashboard Cite

Viability and function of red blood cell concentrates stored at 4 degrees C for 35 days in CPDA‐1, CPDA‐2, or CPDA‐3

Cited by 48 publications

References 15 publications

Metabolic Aspects and Viability of Heparin/CPDA-1-Stored Red Cell Concentrate as a By-Product of a High-Yield Factor VIII Production Method

Metabolic Aspects and Viability of Heparin/CPDA-1-Stored Red Cell Concentrate as a By-Product of a High-Yield Factor VIII Production Method

Biochemistry of Packed Red Blood Cell Concentrates Stored in PAGGS-Sorbitol Solution for 42 Days

Gewinnung, Konservierung, Lagerung von Transfusionsblut

Contact Info

Product

Resources

About