Viability and Developmental Capacity of Eggs from Immature Mice treated with Gonadotrophins

Gates, Allen H.

doi:10.1038/177754a0

Cited by 47 publications

(22 citation statements)

References 5 publications

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“…The present results confirm previous reports (Mansour, 1959;Land & McGovern, 1968) Gates, 1956; pig: Baker & Dziuk, 1970). However, in the calf only limited development of embryos has been obtained (Onuma & Foote, 1969;Seidel, Larson, Spilman, Hahn & Foote, 1971 The process by which exogenous progesterone increases ovulation rate in lambs is not known and has not been reported previously, although Land & McGovern (1968) suggested that progest¬ erone may increase follicular development when large doses of PMSG are used.…”

Section: Discussionsupporting

confidence: 81%

Reproductive function in prepubertal lambs: ovulation, embryo development and ovarian steroidogenesis

Trounson¹,

Willadsen²,

Moor³

1977

Reproduction

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Section: Discussionsupporting

confidence: 81%

Reproductive function in prepubertal lambs: ovulation, embryo development and ovarian steroidogenesis

Trounson¹,

Willadsen²,

Moor³

1977

Reproduction

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“…Gates (1956) achieved his results with the synchronous combination 3V2-3^2, Boot and Muhlbock (1953) obtained their best results with the combination 3V2-2V2, and F e k e t e and Little (1942) cit. acc.…”

Section: Discussionmentioning

confidence: 94%

“…Comparison of the results so far obtained from research work on the transplantation of mouse ova shows that the best results were obtained by transplanting blastocysts using the operation method (Gates, 1956) -38.75% of developed embryos from the transplan-ted ova (taking into consideration only those females in which at least one egg developed -approximately 50°/o). In other experiments where a similar method was used, the results vary between 20 and 30%.…”

Section: Discussionmentioning

confidence: 99%

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Experiments on the transplantation of ova in mice

Tarkowski¹

1958

Acta Theriol.

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“…The original protocol by Gates 8 is still in use. Superovulation is indispensible for embryocryopreservation programmes and the generation of genetically-modified mice.…”

mentioning

confidence: 99%

Treatment of male mice with gonadotropins to improve the fertilization rate and reproduction

et al. 2013

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The possibility of modifying the genome in mice has led to an exponential increase in the number of strains that have been developed for biomedical research. This will continue during the next few decades because international programmes plan to develop genetically-modified strains for every known mouse gene. Due to our own experiences and that of colleagues we know that the reproductive performance of many of these modified stains is impeded, despite that the modification is independent from genes that control reproduction. In some cases the spermatogenesis might be disturbed. The reason presumably lies in a defective endocrine function of the testes. This can cause reduced and/or abnormal sperm production. In livestock as well as in humans these disorders can be treated with gonadotropins. One treatment period lasts for the duration of spermatogenesis of the respective species. Up to now, nothing is known about such treatments in laboratory mice to restore or increase reproduction of genetically-modified strains. Spermatogenesis in the mouse lasts approximately 35 days. Therefore, we treated sexually mature male mice of C57BL/6 and BALB/c strains with gonadotropins for this period. The aim of this study was to test the principle suitability of such treatment for the improvement of sperm count, sperm motility, fertilization ability and reproduction.

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Viability and Developmental Capacity of Eggs from Immature Mice treated with Gonadotrophins

Cited by 47 publications

References 5 publications

Reproductive function in prepubertal lambs: ovulation, embryo development and ovarian steroidogenesis

Reproductive function in prepubertal lambs: ovulation, embryo development and ovarian steroidogenesis

Experiments on the transplantation of ova in mice

Treatment of male mice with gonadotropins to improve the fertilization rate and reproduction

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