VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions

Xu, Wendao; Zhang, Shuihua; Zhou, Quan; Chen, Wenli

doi:10.1080/21691401.2019.1626411

Cited by 27 publications

(21 citation statements)

References 39 publications

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“…The MSNs were additionally loaded with DOX [ 103 ]. SPION/MSN composites have also been functionalised with tumour-targeting peptides with Xu et al tethering VHPKQHR (Val-His-Pro-Lys-Glu-His-Arg) to the MSN shell for targeting of vascular cell adhesion molecule-1 (VCAM-1), providing direct negative contrast MRI reporting on atherosclerotic plaque in vivo [ 104 ].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Mesoporous Silica Nanoparticles in Bioimaging

2020

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A biomedical contrast agent serves to enhance the visualisation of a specific (potentially targeted) physiological region. In recent years, mesoporous silica nanoparticles (MSNs) have developed as a flexible imaging platform of tuneable size/morphology, abundant surface chemistry, biocompatibility and otherwise useful physiochemical properties. This review discusses MSN structural types and synthetic strategies, as well as methods for surface functionalisation. Recent applications in biomedical imaging are then discussed, with a specific emphasis on magnetic resonance and optical modes together with utility in multimodal imaging.

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Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Mesoporous Silica Nanoparticles in Bioimaging

2020

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“…In vivo, IONPs identified VCAM-1-expressing ECs in a murine tumor necrosis factor-alpha-induced inflammation model and colocalized with VCAM-1-expressing cells in atherosclerotic lesions present in cholesterol-fed ApoE −/− mice. In similar studies, magnetic NPs modified with VHPKQHR peptides were used for targeting VCAM-1-expressing cells [ 170 ], which could in principle be loaded with therapeutic agents and thus be suitable for drug delivery [ 171 ]. In the study by Michalska et al, the use of ultra-small IONPs functionalized with VCAM-1-binding peptide (P03011) resulted in a distinct visualization of the aortic root of ApoE −/− mice [ 172 ].…”

Section: Cardiovascular Tissue Regeneration and Engineeringmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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“…Xu et al designed mesoporous silica nanoparticles that could target vascular cell adhesion molecule 1 (VCAM-1) expressed by endothelial cells. 72 In the treatment of AS, Huang et al synthesized a paclitaxel drug-loaded platelet membrane bionic Janus mesoporous silica porous nanomotors (JAMS) that were obtained by asymmetric modification of platinum (Pt) nanoparticles. 71 After the NIR irradiation, the nanomotors can not only penetrate the plaque and enhance the drug retention efficiency but also realize short-term photothermal elimination of inflammatory macrophages and longterm anti-proliferation effect of the drug (Figure 5C).…”

Section: Application Of Mesoporous Silica Nanomaterial-based Drug Delivery System In Atherosclerosismentioning

confidence: 99%

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Sha¹,

Dai²,

Song³

et al. 2021

IJN

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Atherosclerosis (AS) as the leading cause of cardiovascular and cerebrovascular events has been paid much attention all the time. With the continuous development of modern medical drug treatment, surgical treatment, interventional treatment and other methods, the mortality rate of AS has shown a downward trend, while the morbidity rate is still increasing. Oral lipid-lowering or anti-inflammatory drugs are generally used for early AS, but the relatively low accumulation efficiency in lesions and the unavoidable side effects required researchers to develop more effective drug delivery approaches for the therapy of AS. Mesoporous silica nanoparticles as nanocarrier for drug delivery have received extensive attentions due to their flexible size, high specific surface area, controlled pore volume, high drug loading capacity and excellent biocompatibility. Series of good reviews about the mesoporous silica nanoparticles loaded drugs for cancer therapy have been well documented. However, their roles as nanocarrier for drug delivery to treat AS have few reports. In this review, the applications and challenges of mesoporous silica nanomaterials in the field of the diagnosis and therapy of AS have been summarized. The classification, synthesis, formation mechanism, surface modification and functionalization of mesoporous silica nanomaterials which were closely related to the theranostic effect of AS have also been included. Last but not the least, the future prospects’ suggestions of mesoporous silica nanomaterial-based drug delivery system for AS are also provided.

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VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions

Cited by 27 publications

References 39 publications

Mesoporous Silica Nanoparticles in Bioimaging

Mesoporous Silica Nanoparticles in Bioimaging

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

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