VHL-Modified PROteolysis TArgeting Chimeras (PROTACs) as a Strategy to Evade Metabolic Degradation in In Vitro Applications

Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

“…To date, our group's interest in targeted protein degradation applied to different research fields 19–22 led us to synthesize a wide structurally heterogeneous library of more than 100 PROTACs. During the preparation of this library, we obtained consistently low yields, particularly in the last coupling synthetic amidation step, thus recognizing the need for exploring and identifying better reaction parameters/conditions.…”