Veterinary oncology: A survey

Cotchin, E.

doi:10.1002/path.1711420202

Cited by 20 publications

(9 citation statements)

References 257 publications

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“…The tumour does not show * Animals were maintained under the guidelines prescribed by the Faculty of Veterinary Medicine, State University Utrecht, The Netherlands ** Grant recipient of the Koningin Wilhelmina Fonds (Netherlands Cancer Foundation) Offprint requests to: W. R. Klein metastatic potency, but is notoriously refractory to local treatment. The question raised by Cotchin [7,8] as to whether sarcoids are real neoplasms is still difficult to answer. Sarcoids demonstrate some characteristics, such as local aggressive growth and proneness to recurrence, which are shared by locally malignant tumours and by tumour-like lesions such as fibromatosis and keloids.…”

Section: Introductionmentioning

confidence: 98%

Equine sarcoid: BCG immunotherapy compared to cryosurgery in a prospective randomised clinical trial

Misdorp

et al. 1986

Cancer Immunol Immunother

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A total of 30 horses with single or multiple sarcoid tumors of the skin were randomly divided into three treatment groups: (i) cryosurgical treatment, (ii) intralesional immunotherapy with a live BCG vaccine, (iii) intralesional immunotherapy with a BCG cell wall preparation. Complete tumour regression was obtained in all 10 cryosurgically treated horses, in 6 of 10 live BCG treated horses, and in 7 of 10 BCG cell wall treated horses. One live BCG and 2 BCG cell wall treated horses showed partial tumour regression of more than 50% of the tumour area. Eleven horses with sarcoid tumours were not eligible for random allocation in the trial because unfavourable site or size of the tumour precluded cryosurgical treatment. These animals were treated with BCG cell wall vaccine except for 1 animal, which was treated with live BCG. In 4 cases this treatment was combined with cytoreductive surgery of the tumour. In this prognostically unfavourable group 8 animals showed complete tumour regression and 3 animals did not respond. Regression after BCG immunotherapy appeared to correlate with size (larger tumours worse response) and localization of the sarcoid (less favourable results in the limb), and increase in peripheral blood leucocytes after the first injection. Horses with a positive delayed type hypersensitivity reaction to PPD before the start of treatment showed a tendency to more favourable prognosis than PPD negative horses. No correlation was present between regression and single or multiple presence of sarcoids, increase in body temperature after injection of BCG and the formation of specific antibodies to BCG. None of the cured animals have shown tumour recurrence 3 to 40 months following treatment.

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Section: Introductionmentioning

confidence: 98%

Equine sarcoid: BCG immunotherapy compared to cryosurgery in a prospective randomised clinical trial

Misdorp

et al. 1986

Cancer Immunol Immunother

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“…The highest incidence (not age-adjusted) was found at 4-5 yrs (Ramadan et al, 1988), compared with the natural life span of about 13 yrs for goats. It is also of interest that all the published cases of goat melanoma (Ajello, 1970;Amenta, 1931;Bastienello, 1983;Brandly and Magaki, 1963;Cotchin, 1984;Damondaran and Parthasarathy, 1972;Jackson, 1936;Malik et al, 1974;Mustafa et al, 1966;Sastry, 1959;Sockett et al, 1984;Thomas, 1929;Venkatesan et al, 1929;Zubaidy, 1976) have arisen in countries with a high level of solar UV (Africa, the Middle East, India, and the United States of America).…”

Section: Introductionmentioning

confidence: 99%

Histopathology of Melanocytic Lesions in Goats and Establishment of a Melanoma Cell Line: A Potential Model for Human Melanoma

Parsons

Takahashi

Candy

et al. 1990

Pigment Cell Research

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Melanocytic cells from white Angora goats were studied in vivo and in vitro. The histopathology of pigmented areas of skin from the most common sites of melanoma (solar-exposed areas of the ear, face, and perineum) resembled that of the epidermal melanocytes in Hutchinson's melanotic freckle in humans. Seven melanoma biopsies from 6 Angora goats showed histopathological features in common with human melanoma. A melanoma cell line, GM-1, was established in culture from a lymph node metastasis obtained from an animal that had a primary tumor excised and later developed extensive metastatic disease. GM-1 cells were mainly diploid, amelanotic, proliferated rapidly, spontaneously formed vacuolated cells, and were tumorigenic in nude mice. The species of origin of the GM-1 line was confirmed by isozyme profiles. GM-1 cultured cells and the original biopsy both expressed S-100 protein and tyrosinase antigen. Using GM-1 cells as the immunogen, a monoclonal antibody (MoAb 1F1) was derived that reacted strongly with a 116 kDa antigen in 50% of the GM-1 cells, but had little activity with goat fibroblasts (GM-F) or with human melanoma cells. GM-F, on the other hand, yielded more intense staining than GM-1 with an intermediate filament antibody (IFA), reacting with a 58 kDa antigen in both cell lines. The sensitivity of GM-1 to anticancer agents was similar to that of human melanoma cells. The pathology of caprine melanoma and its association with sun-exposed sites in relatively young animals suggest that it may be a suitable model for studying induction of melanoma by natural sunlight.

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“…Teratoma seems to occur more frequently on the left side [1, 4, 5, 7, 9-11, 16, 20, 21, 24, 25], while such predilection has not been reported in women, though [9]. In an examination of 63 cases of canine ovarian tumors by Cotchin including adenoma, adenocarcinoma, granulosacell tumor, and seminoma, it was revealed that the tumors, except for seminoma, occurred more frequently on the left ovary than the right [6]. It has been suggested that generally ovarian tumors have predilection for the left ovary, but the reason remains unknown.…”

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confidence: 99%

Ovarian Teratoma with a Formed Lens and Nonsuppurative Inflammation in an Old Dog

Yamaguchi

Sato

Shibuya

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. A 9-year, 7-month-old female German shepherd weighing 26.6 kg was admitted to the hospital for pica and diarrhea. A large mass was found in the right ovary and removed, and cross section of the mass revealed a multilobular tumor consisting of several cystic cavities which contained tufts of dark hair in thick creamy-white sebaceous fluid. Histologically, the tumor consisted of adipose tissue, central nervous tissue, crystalline lens, cartilage and bone. In the central nervous tissue, lens and lesions like nonsuppurati ve inflammation comprizing of accumulation of glial cells and lymphocytic perivascular cuffing were observed. The tumor was diagnosed as a mature cystic teratoma.

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Veterinary oncology: A survey

Cited by 20 publications

References 257 publications

Equine sarcoid: BCG immunotherapy compared to cryosurgery in a prospective randomised clinical trial

Equine sarcoid: BCG immunotherapy compared to cryosurgery in a prospective randomised clinical trial

Histopathology of Melanocytic Lesions in Goats and Establishment of a Melanoma Cell Line: A Potential Model for Human Melanoma

Ovarian Teratoma with a Formed Lens and Nonsuppurative Inflammation in an Old Dog

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