Veterinary Neurologic Rehabilitation: The Rationale for a Comprehensive Approach

Frank, Lauren R.; Roynard, Patrick

doi:10.1053/j.tcam.2018.04.002

Cited by 28 publications

(23 citation statements)

References 75 publications

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“…Die Akupunktur findet immer mehr Akzeptanz und Beliebtheit in der Tiermedizin, da sie schmerzmodulierende Systeme aktivieren und bei der Linderung von chronischen Schmerzen helfen soll [9]. Die Physiotherapie ist in der Humanmedizin schon seit Längerem integraler Bestandteil der Rehabilitation nach verschiedenen Krankheiten und Eingriffen und wird auch in der Tiermedizin immer mehr eingesetzt [14]. Sie bietet eine professionelle Möglichkeit, die Kleintierpatienten bei ihrer Bewegungstherapie zu begleiten.…”

Section: Nicht Pharmakologisches Managementunclassified

Das Nervenwurzelsyndrom beim Kleintier

Eberhardt

Guevar

Forterre

2019

Tierarztl Prax Ausg K

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ZusammenfassungEine große Vielfalt an Ätiologien gilt als ursächlich für das Nervenwurzelsyndrom beim Hund. Dabei zählen der lateralisierte Bandscheibenvorfall, die Foraminalstenose sowie maligne und benigne Nervenscheidentumoren zu den wichtigsten beschriebenen Auslösern. Das klinische Bild des Nervenwurzelsyndroms zeichnet sich aus durch eine Monoparese in Verbindung mit einer fortschreitenden Lahmheit, die mit einer Schonhaltung der betroffenen Gliedmaße im Stand einhergehen kann. Obwohl die Problematik bei Klinikern gut bekannt ist, gibt es in der tiermedizinischen Literatur keinen Übersichtsartikel, der das Thema „Nervenwurzelsyndrom beim Kleintier“ spezifisch behandelt. Meist wird es lediglich als Symptom seiner potenziellen Ätiologien erwähnt, dem sog. Nervenwurzelzeichen (nerve root sign). Bei der Pathophysiologie der Nervenwurzelkompression oder -irritation spielen eine Reihe biomechanischer und biochemischer Faktoren eine Rolle, die einzeln oder im Zusammenspiel auftreten und dieselben Veränderungen hervorrufen können. Im Zentrum der Pathophysiologie des Syndroms scheinen Änderungen der Mikrozirkulation zu stehen. Diese Mikrozirkulationsstörungen ziehen nicht nur pathomorphologische Veränderungen, wie Ödembildung, Demyelinisation und Axonuntergang, nach sich, sondern leiten auch am Ort der Schädigung sowie im zentralen Nervengewebe eine Kaskade an Reaktionen ein. So kommt es zur Ausschüttung verschiedener Neuropeptide, zur Modulation der Nervenexzitabilität und zur Impulsweiterleitung. Unterschiedliche Pathomechanismen führen somit vielfach zu einem einheitlichen Schädigungsbild, was eine nachträgliche Aufschlüsselung in die ursprünglich auslösenden Faktoren erheblich erschwert. Die Antwort des Körpers auf diese einwirkenden Faktoren gibt den Ausschlag dafür, ob tatsächlich ein Nervenwurzelsyndrom entsteht. Eine Behebung der Grundursache, falls sie gefunden wird, sowie eine individuelle und multimodale Schmerztherapie scheinen beim Nervenwurzelsyndrom die erfolgreichsten therapeutischen Maßnahmen zu sein.

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Section: Nicht Pharmakologisches Managementunclassified

Das Nervenwurzelsyndrom beim Kleintier

Eberhardt

Guevar

Forterre

2019

Tierarztl Prax Ausg K

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“…Prognosis for functional recovery depends on the initial severity (incomplete/complete lesion), location of the injury (cervical, thoracic, lumbar) and general health and age of dogs [ 6 ]. Care during the first two to four days (decompression, stabilization of vertebral column) followed by therapy and rehabilitation are critical for initiating the recovery outcome [ 7 ]. While some SCI dogs receiving the appropriate medical care improve their quality of life and motor function, usually within six months, others proceed into the chronic phase.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the complex anatomy of the spine and its limited regenerative capacity in mammals, there is currently no cure for SCI [ 9 ]. Partial successes have been achieved in acute SCI by enrolling combined treatment strategies and targeted rehabilitation [ 6 , 7 ]. Many traditional therapeutic approaches stabilize or alleviate symptoms.…”

Section: Introductionmentioning

confidence: 99%

Stem Cell Conditioned Medium Treatment for Canine Spinal Cord Injury: Pilot Feasibility Study

Vikartovska

Kuricová

Farbáková

et al. 2020

IJMS

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Spinal cord injury (SCI) involves nerve damage and often leads to motor, sensory and autonomic dysfunctions. In the present study, we have designed a clinical protocol to assess the feasibility of systemic delivery of allogenic canine bone marrow tissue-derived mesenchymal stem cell conditioned medium (BMMSC CM) to dogs with SCI. Four client-owned dogs with chronic SCI lasting more than six months underwent neurological and clinical evaluation, MRI imaging and blood tests before being enrolled in this study. All dogs received four intravenous infusions with canine allogenic BMMSC CM within one month. Between the infusions the dogs received comprehensive physiotherapy, which continued for three additional months. No adverse effects or complications were observed during the one, three and six months follow-up periods. Neither blood chemistry panel nor hematology profile showed any significant changes. All dogs were clinically improved as assessed using Olby locomotor scales after one, three and six months of BMMSC CM treatment. Furthermore, goniometric measurements revealed partial improvement in the range of joint motion. Bladder function improved in two disabled dogs. We conclude that multiple delivery of allogenic cell-derived conditioned medium to dogs with chronic SCI is feasible, and it might be clinically beneficial in combination with physiotherapy.

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“…Low Level Laser Therapy (LLLT), has been investigated in veterinary medicine owing to its potential ability to relieve pain, reduce inflammation, and accelerate the healing process [15,16]. All these advantages are related to the ability of photobiomodulation to: promote stimulation of cytochrome oxidase in mitochondria with production of adenosine triphosphate (ATP); limit the inflammatory process and leukotriene activity; and improve the release of endorphins and serotonin [17][18][19][20][21][22][23][24][25][26][27]. Several studies have also been conducted to prove the positive effect of LLLT on neural recovery [20,23,26].…”

Section: Introductionmentioning

confidence: 99%

Perilesional photobiomodulation therapy and physical rehabilitation in post-operative recovery of dogs surgically treated for thoracolumbar disk extrusion

Bruno¹,

Canal²,

Antonucci³

et al. 2020

BMC Vet Res

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Background: Recent studies have reported contrasting results of the effects of laser therapy on post-operative intervertebral disk herniation, with a lack of evidence-based advantages of this modality within a rehabilitation protocol. The aim of this study was to report the clinical effects of photobiomodulation therapy within a post-operative rehabilitation protocol in dogs submitted to surgery for thoracolumbar disk extrusion. Twenty-four dogs were included in the study (12 dogs treated with laser therapy and rehabilitation protocol and 12 dogs treated with same rehabilitation protocol but without laser therapy). Results: All dogs treated with laser therapy showed improved neurological status (Modified Frankel Score more than 3 within 30 days of physiotherapy starting) if deep nociception on admission was maintained (P = 0.04). However, Kaplan-Meier analysis did not show any statistical difference in time to regain ambulatory ability, although there was a tendency for a shorter mean time of 14.2 ± 8.55 days in the laser group versus 24 ± 18.49 days in the no laser group. Conclusions: The use of laser therapy in the post-operative rehabilitation of dogs affected by intervertebral disc extrusion and submitted to surgery for spinal decompression could help improve their neurological status.

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Veterinary Neurologic Rehabilitation: The Rationale for a Comprehensive Approach

Cited by 28 publications

References 75 publications

Das Nervenwurzelsyndrom beim Kleintier

Das Nervenwurzelsyndrom beim Kleintier

Stem Cell Conditioned Medium Treatment for Canine Spinal Cord Injury: Pilot Feasibility Study

Perilesional photobiomodulation therapy and physical rehabilitation in post-operative recovery of dogs surgically treated for thoracolumbar disk extrusion

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