Vestibuloprotective and antiamnestic properties of adrenocorticotropic hormone fragments and their analogs

Abstract

It is established that low-intensity electromagnetic waves of superhigh frequency and motion sickness induce in rats a retrograde amnesia revealed in the passive avoidance test. Fragments of adrenocorticotropic hormone (ACTH) (4-10) and (5-10), ORG-2766 [ACTH (4-9) analog], and a domestic ACTH (4-10) analog, ACTH (4-7)-Pro-Gly-Pro (semax), in doses of 0.05-0.1 rng/kg significantly weaken the anamnestic effect of both extreme factors. Semax and ORG-2766 also possess a marked anti-motion sickness activity.

Effect of semax and ACTH (5–10) on electrical activity of central neurons

“…Thus, our findings suggest that the majority of cortical neurons (60%) are sensitive to semax and ACTH (5)(6)(7)(8)(9)(10). This may account for their effect on general integrative function of the brain.…”

“…ACTH (5)(6)(7)(8)(9)(10) and semax applied to individual MVN cells predominantly inhibited their spontaneous activity (41 and 48% neurons, respectively, Table 1). ACTH (5)(6)(7)(8)(9)(10) and semax applied to individual MVN cells predominantly inhibited their spontaneous activity (41 and 48% neurons, respectively, Table 1).…”