Vestibular processing in human paramedian precuneus as shown by electrical cortical stimulation

Wiest, Gerald; Zimprich, Fritz; Prayer, Daniela; Czech, T.; Serles, Wolfgang; Baumgärtner, C.

doi:10.1212/01.wnl.0000106948.17561.55

Cited by 51 publications

(49 citation statements)

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“…Previous neuroimaging studies showed that the precuneus is also involved in the perception of self-motion (Kovacs et al, 2008), in whole-body motor imagery (Jahn et al, 2004) and mental navigation (Ghaem et al, 1997). The vestibular processing in the precuneus suggested by the present meta-analysis is corroborated by clinical studies showing that electrical stimulation of the precuneus may induce self-motion perception (Kahane et al, 2003;Wiest et al, 2004). We note that, to the best of our knowledge, no homologous region has been described in animals as receiving vestibular inputs.…”

Section: The Human Vestibular Cortexsupporting

confidence: 83%

The human vestibular cortex revealed by coordinate-based activation likelihood estimation meta-analysis

2012

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Abstract-The vestibular system contributes to the control of posture and eye movements and is also involved in various cognitive functions including spatial navigation and memory. These functions are subtended by projections to a vestibular cortex, whose exact location in the human brain is still a matter of debate . The vestibular cortex can be defined as the network of all cortical areas receiving inputs from the vestibular system, including areas where vestibular signals influence the processing of other sensory (e.g. somatosensory and visual) and motor signals. Previous neuroimaging studies used caloric vestibular stimulation (CVS), galvanic vestibular stimulation (GVS), and auditory stimulation (clicks and short-tone bursts) to activate the vestibular receptors and localize the vestibular cortex. However, these three methods differ regarding the receptors stimulated (otoliths, semicircular canals) and the concurrent activation of the tactile, thermal, nociceptive and auditory systems. To evaluate the convergence between these methods and provide a statistical analysis of the localization of the human vestibular cortex, we performed an activation likelihood estimation (ALE) metaanalysis of neuroimaging studies using CVS, GVS, and auditory stimuli. We analyzed a total of 352 activation foci reported in 16 studies carried out in a total of 192 healthy participants. The results reveal that the main regions activated by CVS, GVS, or auditory stimuli were located in the Sylvian fissure, insula, retroinsular cortex, fronto-parietal operculum, superior temporal gyrus, and cingulate cortex. Conjunction analysis indicated that regions showing convergence between two stimulation methods were located in the median (short gyrus III) and posterior (long gyrus IV) insula, parietal operculum and retroinsular cortex (Ri). The only area of convergence between all three methods of stimulation was located in Ri. The data indicate that Ri, parietal operculum and posterior insula are vestibular regions where afferents converge from otoliths and semicircular canals, and may thus be involved in the processing of signals informing about body rotations, translations and tilts. Results from the meta-analysis are in agreement with electrophysiological recordings in monkeys showing main vestibular projections in the transitional zone between Ri, the insular granular field (Ig), and SII. Ó

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Section: The Human Vestibular Cortexsupporting

confidence: 83%

The human vestibular cortex revealed by coordinate-based activation likelihood estimation meta-analysis

2012

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“…Published EEG traces from EVD cases (n 5 33) were reviewed. From the 14 EEG recordings originally rated as ictal, this was confirmed in 11, while in 2 cases 19,20 the EEG data presented was only probably consistent with an ongoing seizure and in one case 21 no seizure was depicted. Diagnosis in the remaining 19 cases (interictal EEG changes) was confirmed.…”

Section: Resultsmentioning

confidence: 78%

“…When obvious seizure-related symptoms or signs (e.g., a generalized convulsion) accompany vestibular symptoms, EVD is readily recognized. EVD causing isolated vestibular symptoms was reported, 2,18,19 but there is limited information about prevalence and clinical characteristics (e.g., accompanying symptoms, duration) that might help distinguish it from nonepileptic causes.…”

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confidence: 99%

Clinical and electrographic findings in epileptic vertigo and dizziness

et al. 2015

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Objective: Seizures can cause vestibular symptoms, even without obvious epileptic features. We sought to characterize epileptic vertigo or dizziness (EVD) to improve differentiation from nonepileptic causes, particularly when vestibular symptoms are the sole manifestation. Methods:We conducted a systematic review with electronic (Medline) and manual search for English-language studies . Two independent reviewers selected studies. Study/patient characteristics were abstracted. We defined 3 study population types: (1) seizures, some experiencing vertigo/dizziness (disease cohort); (2) vertigo/dizziness, some due to seizures (symptom cohort); (3) vertigo/dizziness due to seizures in all patients (EVD-only cohort). Results:We identified 84 studies describing 11,354 patients (disease cohort 5 8,129; symptom cohort 5 2,965; EVD-only cohort 5 260). Among 1,055 EVD patients in whom a distinction could be made, non-isolated EVD was present in 8.5%, isolated EVD in 0.8%. Thorough diagnostic workups (ictal EEG, vestibular testing, and brain MRI to exclude other causes) were rare (,0.1%). Ictal EEG was reported in 487 (4.3%), formal neuro-otologic assessment in 1,107 (9.7%). Localized EEG abnormalities (n 5 350) were most frequently temporal (79.8%) and uncommonly parietal (11.8%). Duration of episodic vestibular symptoms varied, but was very brief (,30 seconds) in 69.6% of isolated EVD and 6.9% of non-isolated EVD.Conclusions: Non-isolated EVD is much more prevalent than isolated EVD, which appears to be rare.Diagnostic evaluations for EVD are often incomplete. EVD is primarily associated with temporal lobe seizures; whether this reflects greater epidemiologic prevalence of temporal lobe seizures or a tighter association with dizziness/vertigo presentations than with other brain regions remains unknown. Consistent with clinical wisdom, isolated EVD spells often last just seconds, although many patients experience longer spells. Neurology ® 2015;84:1595-1604 GLOSSARY AED 5 antiepileptic drug; EVD 5 epileptic vertigo or dizziness; i-EVD 5 isolated epileptic vertigo or dizziness; ni-EVD 5 nonisolated epileptic vertigo or dizziness.

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“…Rotational vertigo may also result from lesion of the inferior parietal cortex or its adjacent parietal white matter (patient #2 from Urasaki and Yokota, 2006;Erbayat Altay et al, 2005;Nicita et al, 2010;Schneider et al, 2006). Finally, human mesial parietal cortex may harbor a vestibular region because vestibular illusions were evoked in epileptic patients during electrical stimulation of the precuneus (Kahane et al, 2003;Wiest et al, 2004).…”

Section: 2mentioning

confidence: 99%

The thalamocortical vestibular system in animals and humans

Lopez

Blanke

2011

Brain Research Reviews

457

379

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The vestibular system provides the brain with sensory signals about three-dimensional head rotations and translations. These signals are important for postural and oculomotor control, as well as for spatial and bodily perception and cognition, and they are subtended by pathways running from the vestibular nuclei to the thalamus, cerebellum and the "vestibular cortex."The present review summarizes current knowledge on the anatomy of the thalamocortical vestibular system and discusses data from electrophysiology and neuroanatomy in animals by comparing them with data from neuroimagery and neurology in humans. Multiple thalamic nuclei are involved in vestibular processing, including the ventroposterior complex, the ventroanterior-ventrolateral complex, the intralaminar nuclei and the posterior nuclear group 2 0 1 1 ) 1 1 9 -1 4 6 Abbreviations: 3aHv, 3a-hand-vestibular area; 3aNv, 3a-neck-vestibular area; ASS, anterior suprasylvian cortex; DVN, descending vestibular nucleus; FEF, frontal eye fields; Ig, insula granularis; IL, intralaminar nuclei; LD, lateral dorsal nucleus; LGN, lateral geniculate nucleus; LP, lateral posterior nucleus; LVN, lateral vestibular nucleus; MGmc, medial geniculate nucleus, pars magnocellularis; MGN, medial geniculate nucleus; MIP, medial intraparietal area; MST, medial superior temporal area; MT, middle temporal area; MVN, medial vestibular nucleus; PIVC, parieto-insular vestibular cortex; PO, posterior group of the thalamus; Reipt, area retroinsularis pars parietalis; Ri, area retroinsularis; SGN, suprageniculate nucleus; SVN, superior vestibular nucleus; TPJ, temporo-parietal junction; VA, ventroanterior thalamic nucleus; Vim, nucleus ventralis intermedius; VIP R A I N R E S E A R C H R E V I E W S 6 7 (

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Vestibular processing in human paramedian precuneus as shown by electrical cortical stimulation

Cited by 51 publications

References 10 publications

The human vestibular cortex revealed by coordinate-based activation likelihood estimation meta-analysis

The human vestibular cortex revealed by coordinate-based activation likelihood estimation meta-analysis

Clinical and electrographic findings in epileptic vertigo and dizziness

The thalamocortical vestibular system in animals and humans

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