Vestibular nucleus neurons relaying excitation from the anterior canal to the oculomotor nucleus

Yamamoto, Miyuki; Shimoyama, Ichiro; Highstein, Stephen M.

doi:10.1016/0006-8993(78)90376-1

Cited by 85 publications

(34 citation statements)

References 15 publications

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“…Only vertical canal-related neurons are found in the central magnocellular sv area. Their connectivity follows the "rule" that ipsilateral projections ascending in MLF to oculomotoneurons are inhibitory, whereas those with crossed projections are excitatory (Gacek, 1971;Ito et al, 1973a,b;Yamamoto et al, 1978;Highstein and Reisine, 1979;Precht, 1979). The lv does not project to nIII.…”

Section: Vestibular Afferentsmentioning

confidence: 95%

Twitch and nontwitch motoneuron subgroups in the oculomotor nucleus of monkeys receive different afferent projections

Wasicky

Horn

Büttner‐Ennever

2004

J of Comparative Neurology

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Motoneurons in the primate oculomotor nucleus can be divided into two categories, those supplying twitch muscle fibers and those supplying nontwitch muscle fibers. Recent studies have shown that twitch motoneurons lie within the classical oculomotor nucleus (nIII), and nontwitch motoneurons lie around the borders. Nontwitch motoneurons of medial and inferior rectus are in the C group dorsomedial to nIII, whereas those of inferior oblique and superior rectus lie near the midline are in the S group. In this anatomical study, afferents to the twitch and nontwitch subgroups of nIII have been anterogradely labeled by injections of tritiated leucine into three areas and compared. 1) Abducens nucleus injections gave rise to silver grain deposits over all medial rectus subgroups, both twitch and nontwitch. 2) Laterally placed vestibular complex injections that included the central superior vestibular nucleus labeled projections only in twitch motoneuron subgroups. However, injections into the parvocellular medial vestibular nucleus (mvp), or Y group, resulted in labeled terminals over both twitch and nontwitch motoneurons. 3) Pretectal injections that included the nucleus of the optic tract (NOT), and the olivary pretectal nucleus (OLN), labeled terminals only over nontwitch motoneurons, in the contralateral C group and in the S group. Our study demonstrates that twitch and nontwitch motoneuron subgroups do not receive identical afferent inputs. They can be controlled either in parallel, or independently, suggesting that they have basically different functions. We propose that twitch motoneurons primarily drive eye movements and nontwitch motoneurons the tonic muscle activity, as in gaze holding and vergence, possibly involving a proprioceptive feedback system.

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Section: Vestibular Afferentsmentioning

confidence: 95%

Twitch and nontwitch motoneuron subgroups in the oculomotor nucleus of monkeys receive different afferent projections

Wasicky

Horn

Büttner‐Ennever

2004

J of Comparative Neurology

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“…The location of secondary vestibular neurons that project to the oculomotor and trochlear nuclei in mammals has been studied using electrophysiological methods, degeneration techniques, and the retrograde transport of horseradish peroxidase (HRP) [Tarlov, 1970;Highstein, 1973;Graybiel and Hartwieg, 1974;Gacek, 1977;Yamamoto et al, 1978;Steiger and Biittner-Ennever, 1979]. The HRP studies were per formed using earlier less sensitive hislochemical methods, and in some cases they constituted only brief descriptions of observations noted in the course of broader investigations.…”

Section: Introductionmentioning

confidence: 99%

Distribution of the Vestibular Neurons Projecting to the Oculomotor and Trochlear Nuclei in Rabbits

et al. 1991

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Horseradish peroxidase and Fast Blue were injected into the oculomotor and trochlear nuclei of rabbits so as to study the distribution of vestibular neurons that project to these nuclei. After the oculomotor nucleus was injected, labelled neurons were found in the superior, medial, and descending vestibular nuclei as well as in cell group Y. In the superior nucleus, most of the neurons (510 ± 46) were ipsilateral to the injection, although contralaterally labelled neurons were also observed (104 ± 19) more peripherally. In cell group Y, 186 ± 24 contralaterally labelled neurons were observed, whereas hardly any (8 ± 3) were found on the ipsilateral side. The largest group of labelled neurons (811 ± 65) constituted a neuronal band located contralaterally in the medial nucleus and rostral part of the descending nucleus. This band rostromedially continued with the caudal part of the group of internuclear neurons of the abducens nucleus. Only 190 ± 31 neurons were labelled in the medial and descending nucleus ipsilateral to the injected oculomotor nucleus. After injection of the trochlear nucleus, labelled neurons were found in the ipsilateral superior nucleus and contralateral medial and descending nuclei; a few labelled cells were also observed in the ipsilateral medial and descending nuclei as well as in the contralateral cell group Y.

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“…However, the central part of the SVN has been reported to receive the highest concentration of primary vestibu- (Walberg et al, 1958;Stein and Carpenter, 1967;Gacek, 1969;Henkel and Martin, 1977a). The ipsilateral vestibular input is monosynaptic and excitatory to all the SVN neurons projecting to the oculomotor complex (Mitsacos et al, 1983a), although some investigators refer to ipsilateral inhibitory inputs (Yamamoto et al, 1978). Only verticalcanal-related neurons have been found in this region, despite the fact that the SVN receives fibers from the horizontal canal.…”

Section: Discussionmentioning

confidence: 95%

“…This group is present in most species, and it receives primary vestibular afferents (Gacek, 1969;Zimny and Sobusiak, 1970;Korte, 1979;Kevetter and Perachio, 1986) mainly from the saccular macula that projects fibers to the contralateral oculomotor nucleus (Yamamoto et al, 1978;Steiger and Buttner-Ennever, 1979) and the cerebellum (Kotchabhakdi and Walberg, 1978). The part of the vestibular complex that assumes its function in man remains to be elucidated.…”

Section: Discussionmentioning

confidence: 98%

“…This fact may have a functional relevance because this is the case of the largest neurons of the SVN. The rostrolateral part of the MVN receives fibers from the cristae (Stein and Carpenter, 1967;Gacek, 1969) and projects into the oculomotor nuclei (Gacek, 1969;Yamamoto et al, 1978;Steiger and Buttner-Ennever, 1979). These efferents provide contralateral excitatory inputs to the abducens nucleus or to the trochlear and the oculomotor nuclei via the medial longitudinal fasciculus (MLF).…”

Section: Discussionmentioning

confidence: 98%

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Morphometric analysis of the human vestibular nuclei

et al. 1997

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Vestibular nucleus neurons relaying excitation from the anterior canal to the oculomotor nucleus

Cited by 85 publications

References 15 publications

Twitch and nontwitch motoneuron subgroups in the oculomotor nucleus of monkeys receive different afferent projections

Twitch and nontwitch motoneuron subgroups in the oculomotor nucleus of monkeys receive different afferent projections

Distribution of the Vestibular Neurons Projecting to the Oculomotor and Trochlear Nuclei in Rabbits

Morphometric analysis of the human vestibular nuclei

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