Vestibular-hippocampal interactions

Smith, Paul F.

doi:10.1002/(sici)1098-1063(1997)7:5<465::aid-hipo3>3.0.co;2-g

Cited by 137 publications

(70 citation statements)

References 80 publications

(104 reference statements)

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“…There is considerable neuroanatomical and neurophysiological support for vestibularhippocampal interaction (reviewed in Smith, 1997). Our present data suggest that such an interaction plays a functionally significant role in hippocampal processing of spatial information.…”

Section: Vestibular-hippocampal Interactionsupporting

confidence: 58%

“…Our present data suggest that such an interaction plays a functionally significant role in hippocampal processing of spatial information. Vestibular input to the hippocampus may update spatial representations as the animal moves, so that the representations reflect current body position (McNaughton et al, 1996;Smith, 1997). Vestibular stimulation activates the hippocampal formation, parietal cortex, and retrosplenial cortex in humans (Vitte et al, 1996) and rats (Horii et al, 1994), and modulates primate hippocampal neuronal activity (O'Mara et al, 1994).…”

Section: Vestibular-hippocampal Interactionmentioning

confidence: 99%

“…Finally, lesions of the vestibular apparatus abolish the directional firing of anterior thalamic neurons and impair spatial memory, as outlined above. Therefore, vestibular input to the hippocampus may be critical for spatial navigation and for updating brain representations of spatial information (McNaughton et al, 1996;Smith, 1997). To test this assumption, we examined the spatial firing of hippocampal neurons before and after reversible inactivation of the vestibular system.…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal spatial representations require vestibular input

2002

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The hippocampal formation is essential for forming declarative representations of the relationships among multiple stimuli. The rodent hippocampal formation, including the entorhinal cortex and subicular complex, is critical for spatial memory. Two classes of hippocampal neurons fire in relation to spatial features. Place cells collectively map spatial locations, with each cell firing only when the animal occupies that cell's "place field," a particular subregion of the larger environment. Head direction (HD) cells encode directional heading, with each HD cell firing when the rat's head is oriented in that cell's particular "preferred firing direction." Both landmarks and internal cues (e.g., vestibular, motor efference copy) influence place and HD cell activity. However, as is the case for navigation, landmarks are believed to exert greater influence over place and HD cell activity. Here we show that temporary inactivation of the vestibular system led to the disruption of location-specific firing in hippocampal place cells and direction-specific discharge of postsubicular HD cells, without altering motor function. Place and HD cell activity recovered over a time course similar to that of the restoration of vestibular function. These results indicate that vestibular signals provide an important influence over the expression of hippocampal spatial representations, and may explain the navigational deficits of humans with vestibular dysfunction.

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Section: Vestibular-hippocampal Interactionsupporting

confidence: 58%

Section: Vestibular-hippocampal Interactionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hippocampal spatial representations require vestibular input

2002

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“…Second, "head direction cells" in the hippocampus, whose firing rate is modulated by the direction an animal is facing, are also strongly depending on vestibular information (Taube, 1998). Yet, the pathways through which vestibular cues reach the hippocampus are not yet clearly established, the main potential candidate being a pathway via the thalamus, the posterior parietal cortex and the perirhinal and entorhinal cortices, although pathways through PIVC or cingulate cortex are also possible (see Smith, 1997).…”

Section: Vestibular Projections To Striate and Extrastriate Visual Comentioning

confidence: 99%

The thalamocortical vestibular system in animals and humans

Lopez

Blanke

2011

Brain Research Reviews

457

379

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The vestibular system provides the brain with sensory signals about three-dimensional head rotations and translations. These signals are important for postural and oculomotor control, as well as for spatial and bodily perception and cognition, and they are subtended by pathways running from the vestibular nuclei to the thalamus, cerebellum and the "vestibular cortex."The present review summarizes current knowledge on the anatomy of the thalamocortical vestibular system and discusses data from electrophysiology and neuroanatomy in animals by comparing them with data from neuroimagery and neurology in humans. Multiple thalamic nuclei are involved in vestibular processing, including the ventroposterior complex, the ventroanterior-ventrolateral complex, the intralaminar nuclei and the posterior nuclear group 2 0 1 1 ) 1 1 9 -1 4 6 Abbreviations: 3aHv, 3a-hand-vestibular area; 3aNv, 3a-neck-vestibular area; ASS, anterior suprasylvian cortex; DVN, descending vestibular nucleus; FEF, frontal eye fields; Ig, insula granularis; IL, intralaminar nuclei; LD, lateral dorsal nucleus; LGN, lateral geniculate nucleus; LP, lateral posterior nucleus; LVN, lateral vestibular nucleus; MGmc, medial geniculate nucleus, pars magnocellularis; MGN, medial geniculate nucleus; MIP, medial intraparietal area; MST, medial superior temporal area; MT, middle temporal area; MVN, medial vestibular nucleus; PIVC, parieto-insular vestibular cortex; PO, posterior group of the thalamus; Reipt, area retroinsularis pars parietalis; Ri, area retroinsularis; SGN, suprageniculate nucleus; SVN, superior vestibular nucleus; TPJ, temporo-parietal junction; VA, ventroanterior thalamic nucleus; Vim, nucleus ventralis intermedius; VIP R A I N R E S E A R C H R E V I E W S 6 7 (

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“…Functionally, this is consistent with a number of behavioral and electrophysiological results showing that parietal function is related to the processing of idiothetic information (Save and Moghaddam, 1996;Chen et al, 1994a,b;see below). An attractive hypothesis is that the APC would provide vestibular information to the hippocampal formation (Smith, 1997).…”

Section: Neuroanatomical Interactions Between the Apc And The Hippocamentioning

confidence: 99%

Hippocampal-parietal cortical interactions in spatial cognition

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Poucet

2000

Hippocampus

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Growing evidence suggests that the associative parietal cortex (APC) of the rat is involved in the processing of spatial information. This observation raises the issue of the respective functions of the APC and the hippocampus in spatial processing as well as of their possible interactions. In this paper, we review neuroanatomical, electrophysiological, and behavioral data that support the existence of such functional interactions. Our hypothesis is that the APC is involved in the initial combination of visuospatial information and self‐motion information necessary for the integration of egocentrically acquired information into allocentrically coded information, the latter step being completed in the hippocampus. The dialogue between the hippocampus and the APC is therefore crucial, particularly when the elaboration and/or updating of an allocentric representation depends on complex combinations of visuospatial and self‐motion information. Hippocampus 10:491–499, 2000 © 2000 Wiley‐Liss, Inc.

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Vestibular-hippocampal interactions

Cited by 137 publications

References 80 publications

Hippocampal spatial representations require vestibular input

Hippocampal spatial representations require vestibular input

The thalamocortical vestibular system in animals and humans

Hippocampal-parietal cortical interactions in spatial cognition

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