Vestibular Functions and Parkinson's Disease

Smith, Paul F.

doi:10.3389/fneur.2018.01085

Cited by 68 publications

(64 citation statements)

References 101 publications

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“…In a model of Parkinson's disease, the lack of dopamine on the injured side leads to rotations by the animal to the ipsilateral side to the lesion. Evidence from animal studies strongly suggests that vestibular input is transmitted to the basal ganglia and to the striatum in particular (59). Thus, circling behaviors could be the result of a striatal electrophysiological imbalance resulting from the electrophysiological imbalance observed in the vestibular nuclei after unilateral vestibular loss.…”

Section: Circling and Rotationsmentioning

confidence: 99%

Quantitative Evaluation of a New Posturo-Locomotor Phenotype in a Rodent Model of Acute Unilateral Vestibulopathy

et al. 2020

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Vestibular pathologies are difficult to diagnose. Existing devices make it possible to quantify and follow the evolution of posturo-locomotor symptoms following vestibular loss in static conditions. However, today, there are no diagnostic tools allowing the quantitative and spontaneous analysis of these symptoms in dynamic situations. With this in mind, we used an open-field video tracking test aiming at identifying specific posturo-locomotor markers in a rodent model of vestibular pathology. Using Ethovision XT 14 software (Noldus), we identified and quantified several behavioral parameters typical of unilateral vestibular lesions in a rat model of vestibular pathology. The unilateral vestibular neurectomy (UVN) rat model reproduces the symptoms of acute unilateral peripheral vestibulopathy in humans. Our data show deficits in locomotion velocity, distance traveled and animal mobility in the first day after the injury. We also highlighted alterations in several parameters, such as head and body acceleration, locomotor pattern, and position of the body, as well as "circling" behavior after vestibular loss. Here, we provide an enriched posturo-locomotor phenotype specific to full and irreversible unilateral vestibular loss. This test helps to strengthen the quantitative evaluation of vestibular disorders in unilateral vestibular lesion rat model. It may also be useful for testing pharmacological compounds promoting the restoration of balance. Transfer of these novel evaluation parameters to human pathology may improve the diagnosis of acute unilateral vestibulopathies and could better follow the evolution of the symptoms upon pharmacological and physical rehabilitation.

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Section: Circling and Rotationsmentioning

confidence: 99%

Quantitative Evaluation of a New Posturo-Locomotor Phenotype in a Rodent Model of Acute Unilateral Vestibulopathy

et al. 2020

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“…Thus, there is little evidence to support vestibular dysfunction in Parkinson’s disease. However, this requires further validation (see Smith, 2018 for a review).…”

Section: Introductionmentioning

confidence: 99%

Visual self-motion cues are impaired yet overweighted during visual–vestibular integration in Parkinson’s disease

Yakubovich

Israeli‐Korn

Halperin

et al. 2020

Brain Communications

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Parkinson’s disease is prototypically a movement disorder. Although perceptual and motor functions are highly interdependent, much less is known about perceptual deficits in Parkinson’s disease, which are less observable by nature, and might go unnoticed if not tested directly. It is therefore imperative to seek and identify these, to fully understand the challenges facing patients with Parkinson’s disease. Also, perceptual deficits may be related to motor symptoms. Posture, gait and balance, affected in Parkinson’s disease, rely on veridical perception of one’s own motion (self-motion) in space. Yet it is not known whether self-motion perception is impaired in Parkinson’s disease. Using a well-established multisensory paradigm of heading discrimination (that has not been previously applied to Parkinson’s disease), we tested unisensory visual and vestibular self-motion perception, as well as multisensory integration of visual and vestibular cues, in 19 Parkinson’s disease, 23 healthy age-matched and 20 healthy young-adult participants. After experiencing vestibular (on a motion platform), visual (optic flow) or multisensory (combined visual–vestibular) self-motion stimuli at various headings, participants reported whether their perceived heading was to the right or left of straight ahead. Parkinson’s disease participants and age-matched controls were tested twice (Parkinson’s disease participants on and off medication). Parkinson’s disease participants demonstrated significantly impaired visual self-motion perception compared with age-matched controls on both visits, irrespective of medication status. Young controls performed slightly (but not significantly) better than age-matched controls and significantly better than the Parkinson’s disease group. The visual self-motion perception impairment in Parkinson’s disease correlated significantly with clinical disease severity. By contrast, vestibular performance was unimpaired in Parkinson’s disease. Remarkably, despite impaired visual self-motion perception, Parkinson’s disease participants significantly overweighted the visual cues during multisensory (visual–vestibular ) integration (compared with Bayesian predictions of optimal integration) and significantly more than controls. These findings indicate that self-motion perception in Parkinson’s disease is affected by impaired visual cues and by suboptimal visual–vestibular integration (overweighting of visual cues). Notably, vestibular self-motion perception was unimpaired. Thus, visual self-motion perception is specifically impaired in early-stage Parkinson’s disease. This can impact Parkinson’s disease diagnosis and subtyping. Overweighting of visual cues could reflect a general multisensory integration deficit in Parkinson’s disease, or specific overestimation of visual cue reliability. Finally, impaired self-motion perception in Parkinson’s disease may contribute to impaired balance and gait control. Future investigation into this connection might open up new avenues of alternative therapies to better treat these difficult symptoms.

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“…Thus, there is little evidence to support vestibular dysfunction in PD. However, this requires further validation (see Smith, 2018 for a review).…”

Section: Introductionmentioning

confidence: 99%

Visual self-motion cues are impaired in Parkinson’s disease yet over-weighted during visual-vestibular integration

Yakubovich

Israeli‐Korn

Halperin

et al. 2019

Preprint

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Background: Parkinson's disease (PD) is prototypically a movement disorder.Although perceptual and motor functions are interdependent, much less is known about perceptual dysfunction in PD. Perceptual deficits can impact activities of daily living, and contribute to motor symptoms, but might go unnoticed if not tested directly. Posture, gait and balance, affected in PD, rely on veridical perception of one's own motion in space. Yet it is unknown whether self-motion perception is impaired in PD. Objectives:To test self-motion perception in PD, separately for visual and vestibular cues (unisensory), and multisensory integration thereof.Methods: Participants (19 early stage PD, 23 age-matched and 20 young adult controls) experienced vestibular (motion platform), visual (optic flow), and combined visual-vestibular self-motion stimuli, and discriminated whether the stimulus headings were rightward or leftward of straight ahead. PD participants and age-matched controls were tested on two visits (PD on and off medication).Results: PD participants had significantly impaired visual self-motion perception, both on and off medication. This deficit correlated significantly with clinical disease severity. By contrast, their vestibular performance was unimpaired. Remarkably, despite impaired visual self-motion perception, PD participants significantly overweighted visual cues during multisensory (visual-vestibular) integration. Conclusions:Self-motion perception is affected already in early stage PD, specifically by impaired visual (vs. vestibular) function, and by suboptimal visualvestibular integration. This may contribute to impaired balance and gait control. Future investigation into this connection might open up new avenues for alternativetherapies to better treat these symptoms. Furthermore, these results may also impact early PD diagnosis and subtyping.

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Vestibular Functions and Parkinson's Disease

Cited by 68 publications

References 101 publications

Quantitative Evaluation of a New Posturo-Locomotor Phenotype in a Rodent Model of Acute Unilateral Vestibulopathy

Quantitative Evaluation of a New Posturo-Locomotor Phenotype in a Rodent Model of Acute Unilateral Vestibulopathy

Visual self-motion cues are impaired yet overweighted during visual–vestibular integration in Parkinson’s disease

Visual self-motion cues are impaired in Parkinson’s disease yet over-weighted during visual-vestibular integration

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