Vestibular Evoked Myogenic Potentials in Acute Acoustic Trauma

Wang, Yen-Pin; Hsu, Wei‐Chung; Young, Yi‐Ho

doi:10.1097/01.mao.0000231590.57348.4b

Cited by 31 publications

(27 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nonsyndromic nature of Cx30 Ϫ/Ϫ mutant mice could be explained by vestibular compensation, which is a well-known phenomenon confirmed in patients after unilateral removal of vestibular schwanoma (Wiegand et al, 1996). This interpretation is consistent with the fact that most Cx mutant patients (Sheykholeslami et al, 2004;Wang et al, 2006). In addition, the Tullio effect, whereby high-level sound stimulation induces eye movements and postural changes, could conceivably be used to test saccule dysfunction further in Cx30 Ϫ/Ϫ mice (Dieterich et al, 1989).…”

Section: Discussionsupporting

confidence: 79%

Analysis of connexin subunits required for the survival of vestibular hair cells

Tang

Dahlke

et al. 2007

J of Comparative Neurology

View full text Add to dashboard Cite

Mutations in connexin (Cx) genes are responsible for a large proportion of human inherited prelingual deafness cases. The most commonly found human Cx mutations are either Cx26 or Cx30 deletions. Histological observations made in the organ of Corti of homozygous Cx26 and Cx30 gene knockout mice show that cochlear hair cells degenerate after the onset of hearing. However, it is unclear whether vestibular hair cells undergo similar degeneration in connexin knockout mice. To address this question, we first examined expression patterns of Cx26 and Cx30 in the saccule, utricle, and ampulla by immunolabeling. In wild-type mice, Cx26 and Cx30 immunoreactivity was found extensively in vestibular supporting cells and connective tissue cells, and the two Cxs were co-localized in most gap junction (GJ) plaques. Targeted deletion of the Cx30 gene, which caused little change in Cx26 expression pattern, resulted in a significant and age-related loss of vestibular hair cells only in the saccule. dUTP nick end labeling (TUNEL) staining also revealed on-going apoptosis specifically in saccular hair cells of Cx30(-/-) mice. These results indicated that hair cell survival in the utricle and ampulae does not require Cx30. Importantly, over-expressing the Cx26 gene from a modified bacterial artificial chromosome in the Cx30(-/-) background rescued the saccular hair cells. These results suggest that it is the reduction in the total amount of GJs rather than the specific loss of Cx30 that underlies saccular hair cell death in Cx30(-/-) mice. Hybrid GJs co-assembled from Cx26 and Cx30 were not essential for the survival of saccular hair cells.

show abstract

Section: Discussionsupporting

confidence: 79%

Analysis of connexin subunits required for the survival of vestibular hair cells

Tang

Dahlke

et al. 2007

J of Comparative Neurology

View full text Add to dashboard Cite

show abstract

“…Recently, the VEMP test has been adopted to evaluate the impact of noise on the saccule, which is anatomically proximal to the footplate of the stapes, and this test has been validated to reflect the sacculo-collic reflex (Uchino et al, 1997). Previous reports by the authors revealed that subjects with acute acoustic trauma or chronic noise-induced hearing loss may display abnormal VEMPs, indicating that the severity of damage to the cochlea and saccule increases with noise intensity (Wang et al, 2006;Wang & Young, 2007). Since the effects on hearing and VEMPs by occupational and recreational noise exposure have been investigated, it should be valuable to study those of gunshot noise exposure.…”

Section: Sumariomentioning

confidence: 98%

Ten-year longitudinal study of the effect of impulse noise exposure from gunshot on inner ear function

Young

2009

International Journal of Audiology

Self Cite

View full text Add to dashboard Cite

This longitudinal study investigated how chronic gunshot noise exposure affects cochlear and saccular function in police officers who engaged in regular target shooting practice using dual protection (ear plugs plus earmuffs) for >10 years. In 1997, 20 male police officers underwent audiometry before and two weeks after shooting. Twelve of the original subjects were re-examined by audiometry coupled with vestibular evoked myogenic potential (VEMP) test in 2007. Significant deterioration of mean hearing thresholds at frequencies of 500 Hz through 4000 Hz was noted ten years later, affecting both ears. However, only the frequencies of 4000 and 6000 Hz on the left ear revealed significant difference in mean hearing thresholds compared with healthy controls. Abnormal VEMP responses were evident in nine police officers (75%), including absent VEMPs 7 and delayed VEMPs 2. In conclusion, deterioration to hearing may occur after long term exposure to gunshots, even when double hearing protection is used. Further study is in progress regarding how to preserve both cochlear and saccular function during long term gunshot exposure.

show abstract

“…There is increasing evidence for noise-induced vestibular deficiency, through a mechanism of noise-induced damage to the sacculocolic reflex pathway and/or damage to the vestibular hair cell cilia [62, 130]. This is supported by multiple studies in human and animals.…”

Section: Beyond Hearing Loss: Associated Symptomatologymentioning

confidence: 99%

Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options

Le¹,

Straatman²,

Lea³

et al. 2017

J of Otolaryngol - Head & Neck Surg

311

235

View full text Add to dashboard Cite

BackgroundNoise-induced hearing loss is one of the most common forms of sensorineural hearing loss, is a major health problem, is largely preventable and is probably more widespread than revealed by conventional pure tone threshold testing. Noise-induced damage to the cochlea is traditionally considered to be associated with symmetrical mild to moderate hearing loss with associated tinnitus; however, there is a significant number of patients with asymmetrical thresholds and, depending on the exposure, severe to profound hearing loss as well.Main bodyRecent epidemiology and animal studies have provided further insight into the pathophysiology, clinical findings, social and economic impacts of noise-induced hearing loss. Furthermore, it is recently shown that acoustic trauma is associated with vestibular dysfunction, with associated dizziness that is not always measurable with current techniques. Deliberation of the prevalence, treatment and prevention of noise-induced hearing loss is important and timely. Currently, prevention and protection are the first lines of defence, although promising protective effects are emerging from multiple different pharmaceutical agents, such as steroids, antioxidants and neurotrophins.ConclusionThis review provides a comprehensive update on the pathophysiology, investigations, prevalence of asymmetry, associated symptoms, and current strategies on the prevention and treatment of noise-induced hearing loss.

show abstract

Vestibular Evoked Myogenic Potentials in Acute Acoustic Trauma

Cited by 31 publications

References 24 publications

Analysis of connexin subunits required for the survival of vestibular hair cells

Analysis of connexin subunits required for the survival of vestibular hair cells

Ten-year longitudinal study of the effect of impulse noise exposure from gunshot on inner ear function

Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options

Contact Info

Product

Resources

About