Vestibular-evoked myogenic potential in patients with unilateral vestibular neuritis: abnormal VEMP and its recovery

Ochi, Kentaro; Ohashi, Toru; Watanabe, Shôji

doi:10.1258/002221503762624521

Cited by 58 publications

(39 citation statements)

References 12 publications

(21 reference statements)

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“…In recent years, VEMPs have become increasingly accepted as a reliable method of assessing otolith function [45,47]. They have been applied in cases of peripheral vestibular diseases such as Menière's disease [1,12,27,32,46], vestibular neuritis [8,35], vestibular schwannomas [31,40], bilateral vestibulopathy [28], and superior semicircular canal dehiscence [5,30].…”

Section: Introductionmentioning

confidence: 99%

Vestibular-evoked myogenic potentials in vestibular migraine

2009

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Sound-induced vestibular-evoked myogenic potentials (VEMPs) can be used to investigate saccular function, measured from the tonically contracted sternocleidomastoid muscles (SCM) in response to loud sound stimuli. The aim of the present study was to assess VEMPs in patients with vestibular migraine and to determine whether saccular function is affected by the disease. Furthermore, tests such as tilts of subjective visual vertical (SVV) and caloric testing were conducted to test whether deficits in the various tests are associated with each other. The amplitude and latency of VEMPs were measured from the SCM in 63 patients with vestibular migraine (median age 47 years; range 24-70 years) and compared with those of 63 sex- and age-matched healthy controls (median age 46 years; range 17-73 years). Of the 63 patients with vestibular migraine, 43 (68%) had reduced EMG-corrected VEMP amplitudes compared to the controls. Thus, the mean of the p13-n23 amplitudes of the vestibular migraine patients were 1.22 (SE +/-0.09) for the right and 1.21 (SE +/-0.09) for the left side, whereas the averaged amplitudes of the 63 healthy controls showed a mean of 1.79 (SE +/-0.09) on the right and of 1.76 (SE +/-0.09) on the left. No difference was seen in the latencies and there was no correlation between VEMP amplitudes, tilts of SVV and caloric testing. Our data on patients with vestibular migraine indicate that the VEMP amplitudes are significantly and bilaterally reduced compared to those of controls. This electrophysiological finding suggests that both peripheral vestibular structures, such as the saccule, but also central vestibular structures are affected. Thus, beside the brainstem, structures in the inner ear also seem to contribute to vertigo in vestibular migraine.

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Section: Introductionmentioning

confidence: 99%

Vestibular-evoked myogenic potentials in vestibular migraine

2009

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“…VEMPs are based on the residual acoustic sensitivity of the sacculus and a response pathway, which is most likely oligosynaptic, consisting of primary vestibular afferents to the inferior and lateral vestibular nuclei and via the vestibulospinal tract to the accessory nucleus [11,18,22,23,33,36,37]. This method is widely used to test the saccular otolithic vestibulo-spinal reflexes, e.g., in patients with vestibular neuritis [7,24,26] or vestibular schwannomas [25,27,31,34].…”

Section: Introductionmentioning

confidence: 99%

Saccular function less affected than canal function in bilateral vestibulopathy

et al. 2008

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Bilateral vestibulopathy (BV) is characterized by impaired or lost function of both labyrinths or eighth nerves. The diagnosis is routinely established by the head-thrust test, caloric irrigation and rotational testing with electronystagmography to determine the high- and low-frequency deficit of the vestibulo-ocular reflex. All three methods evaluate semicircular canal function only. Vestibular-evoked myogenic potentials (VEMPs) provide a measure of saccular otolith function. The aim of this study was to evaluate the frequency and extent of saccular dysfunction in patients with BV and to correlate saccular with horizontal semicircular canal dysfunction. A total of 84 BV-patients (23 females, mean age 62 +/- 15 (SD) years at the time of diagnosis assessment) were examined with VEMPs, electronystagmography with caloric irrigation and a standardized neuro-ophthalmological and -otological examination; 47 healthy subjects (18 females, mean 56 +/- 19 years) served as controls. Amplitudes P1-N1 were significantly lower in patients with BV compared to controls (mean P1-N1 of all ears 82.1 +/- 50.7 microV in the patients vs. 130.8 +/- 85.9 microV in healthy volunteers). VEMPs were absent unilaterally in four patients with BV and in none bilaterally. In contrast, caloric responses were absent bilaterally in 40 patients. There was no correlation between amplitude P1-N1 and caloric-induced nystagmus. The latencies P1 and N1 were not significantly different between patients and controls. Thus, in our study population saccular function appeared to be less affected than horizontal semicircular canal function.

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“…VEMP has been utilized for the diagnosis of various disorders such as, Meniere's disease [2,3], Acoustic neuromas [4,5,6], Superior canal Dehiscence syndrome, [7], Vestibular neuritis [8],Vertigo [9] ,Noise induced hearing loss [10], Auditory neuropathy / audio vestibular neuropathy [11] and in other disorders such as cerebellopontine angle tumor [3] , Multiple sclerosis. [2] .…”

Section: Page 7748mentioning

confidence: 99%