Vessels of rejuvenation

Noble, Ferdinand le; Noble, Jos le

doi:10.1038/nature13210

Cited by 32 publications

(25 citation statements)

References 10 publications

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“…This has great clinical significance in the improvement of osteoporosis and prevention of fragility fractures by promoting blood vessel formation in bone. Type H vessels combine angiogenesis and osteogenesis in murine bone, which decreases along with ageing ( 19 , 32 , 33 ). DFO could increase type H vessel formation and improve BMD in aged mice ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Synergistic protection of bone vasculature and bone mass by desferrioxamine in osteoporotic mice

Wang

Jia

Shan

et al. 2017

Molecular Medicine Reports

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It has previously been demonstrated that impaired angiogenesis is associated with metabolic abnormalities in bone in addition to osteoporosis (including postmenopausal osteoporosis). Enhancing vessel formation in bone is therefore a potential clinical therapy for osteoporosis. The present study conducted an in-depth investigation using desferrioxamine (DFO) in an ovariectomy (OVX)-induced osteoporotic mouse model in order to determine the time frame of alteration of bone characteristics and the therapeutic effect of DFO. It was demonstrated that OVX induced instant bone mass loss 1 week following surgery, as expected. In contrast, DFO treatment protected the mice against OVX-induced osteoporosis during the first week, however failed to achieve long-term protection at a later stage. A parallel alteration for cluster of differentiation 31/endomucin double positive vessels (type H vessels) was observed, which have previously been reported to be associated with osteogenesis. DFO administration not only partially prevented bone loss and maintained trabecular bone microarchitecture, however additionally enhanced the type H vessels during the first week post-OVX. The molecular mechanism of how DFO influences type H vessels to regulate bone metabolism needs to be further investigated. However, the findings of the present study provide preliminary evidence to support combined vascular and osseous therapies for osteoporotic patients. Pharmacotherapy may offer a novel target for improving osteoporosis by promoting type H vessel formation, which indicates potential clinical significance in the field of bone metabolism.

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Section: Discussionmentioning

confidence: 99%

Synergistic protection of bone vasculature and bone mass by desferrioxamine in osteoporotic mice

Wang

Jia

Shan

et al. 2017

Molecular Medicine Reports

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“…Nevertheless, this pathway was able to restore bone mass and angiogenesis in aged mice. These findings have led some authors to name type H endothelium “vessels of rejuvenation” (le Noble and le Noble 2014). Type H endothelium expresses high levels of CD31, Pecam1, and endomucin and it produces significant levels of Pdgfa, Pdgfb, Tgfb1, Tgfb3, and Fgf1 transcripts, which attract osteogenic cell types.…”

Section: Musculoskeletal Vasculaturementioning

confidence: 99%

Ageing in the musculoskeletal system

Roberts¹,

Colombier²,

Sowman³

et al. 2016

Acta Orthopaedica

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The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mobility. This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) (Regeneration in the Ageing Population) about how each particular cell type alters within the ageing skeletal microenvironment.

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“…Support the blood supply. Neovascularization of a healing wound is paramount to its recovery and rehabilitation (19). To ensure neovascularization the graft must be stable, protected, and remain immobile, critically so during the first phases of wound healing.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect of I-Gen Titanium Membrane Around Immediate Dental Implants Replacing Posterior Mandibular Tooth With Buccal Bone Defect

Sakr

Shaaban

Elsheikh

2017

Alexandria Dental Journal

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INTRODUCTION: Reconstruction of the oral supporting tissues lost by disease or trauma is essential to tooth replacement with dental implant therapy. This treatment requires evidence based augmentative procedures combined with up-to-date and current techniques. Guided bone regeneration (GBR) aims to initialize this process of alveolar ridge reconstruction by utilizing biologically active and supportive materials best coupled to the body's healing processes. The use of non resorbable, titanium membranes can achieve GBR by ensuring graft stability and space maintenance so as to ensure optimal neovascularization. OBJECTIVES: evaluate the use of I-Gen titanium membrane used with immediately placed implant replacing a posterior mandibular tooth with buccal bone defect. MATERIALS AND METHODS: This study was conducted clinically on 10 patients indicated for extraction of a posterior tooth with buccal bone defect, tooth was extracted and an immediate implant, bone graft and I gen titanium membrane were placed. Patients were evaluated clinically and radiographically by using panoramic radiograph and cone beam computed tomography (CBCT). RESULTS: In this study no severe pain was recorded postoperatively. No signs of inflammation or swelling were observed in almost all of the patients along the follow up period. Sufficient bone thickness which is a minimum of 2 mm was formed in the targeted defect with good stability of the implants after 6 months. CONCLUSIONS: I gen titanium mesh should be considered as a valuable option for GBR in small and medium sized bone defects.

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Vessels of rejuvenation

Abstract: The identification of specialized endothelial-cell populations in the blood vessels of bones, and their signalling pathways, reveals how the vasculature contributes to bone formation.

Cited by 32 publications

References 10 publications

Synergistic protection of bone vasculature and bone mass by desferrioxamine in osteoporotic mice

Synergistic protection of bone vasculature and bone mass by desferrioxamine in osteoporotic mice

Ageing in the musculoskeletal system

Evaluation of the Effect of I-Gen Titanium Membrane Around Immediate Dental Implants Replacing Posterior Mandibular Tooth With Buccal Bone Defect

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