Vessel Wall Magnetic Resonance Imaging Identifies the Site of Rupture in Patients With Multiple Intracranial Aneurysms

Matouk, Charles; Mandell, Daniel M.; Günel, Murat; Bulsara, Ketan R.; Malhotra, Ajay; Hebert, Ryan; Johnson, Michele H.; Mikulis, David J.; Minja, Frank J.

doi:10.1227/neu.0b013e31827d1012

Cited by 196 publications

(122 citation statements)

References 19 publications

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“…2 Gadolinium enhancement of the walls of ruptured but not unruptured aneurysms on MRI is supportive of wall inflammation. 8 Hoh et al also found capillaries, however, which appears to be a novel observation in small aneurysms, although the photomicrographs provided here are not that clear to me. Large and giant aneurysms certainly can have capillaries or vasa vasorum, although the average size of aneurysms in this series was approximately 8 mm.…”

contrasting

confidence: 46%

Editorial: Aneurysm wall inflammation

Macdonald¹

2014

JNS

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Hoh and colleagues investigate the hypothesis that stromal cell-derived factor-1 (SDF-1) mediates angiogenesis and inflammation in intracranial saccular aneurysm walls and that the latter two processes are important in aneurysm formation and rupture.3 Stromal cell-derived factor-1 is a chemokine known to be involved in angiogenesis and activation of inflammation. Chemokines are one subtype of cytokines. They are signaling proteins that derive their name from their ability to induce chemotaxis in cells close to them; hence, chemokines from chemotactic cytokines. Chemokines tend to be 8-10 kDa in molecular weight and contain 4 cysteine residues at characteristic locations in their structure. There are approximately 47 mammalian chemokines and they act on about 17 different G-protein coupled receptors on the different types of leucocytes.Hoh et al. found that SDF-1 was present in the walls of mouse and human cerebral aneurysms. Circulating progenitor cells expressing CXCR4, a receptor for SDF-1, were increased in mice that were injected with elastase in order to induce aneurysms. The mouse aneurysms were created by injection of elastase around the extracranial cervical arteries or the intracranial circle of Willis. In the extracranial mouse aneurysm model, administration of an antibody to SDF-1 reduced endothelial cells, capillaries, and cell proliferation in the aneurysms. These findings have not been reported in models of cerebral aneurysms.

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confidence: 46%

Editorial: Aneurysm wall inflammation

Macdonald¹

2014

JNS

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“…[1][2][3][4] Previous reports established a link between ruptured aneurysms and wall enhancement by using qualitative vessel wall MR imaging assessments. 1,5,6 However wall enhancement was also observed in unruptured aneurysms 1,6 ; thus, we hypothesized that the degree of enhancement is higher in ruptured than in unruptured aneurysms. In this study, we used a quantitative method to compare the degree of enhancement between ruptured and unruptured intracranial aneurysms by using a 3D-T1WI FSE sequence.…”

mentioning

confidence: 98%

Quantitative Assessment of Circumferential Enhancement along the Wall of Cerebral Aneurysms Using MR Imaging

Omodaka¹,

Endo²,

Niizuma

et al. 2016

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:The incidence of wall enhancement of cerebral aneurysms on vessel wall MR imaging has been described as higher in ruptured intracranial aneurysms than in unruptured intracranial aneurysms, but the difference in the degree of enhancement between ruptured and unruptured aneurysms is unknown. We compared the degree of enhancement between ruptured and unruptured intracranial aneurysms by using quantitative MR imaging measures.

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“…A VW-MR imaging study 81 of 5 patients with aneurysmal subarachnoid hemorrhage found that all ruptured aneurysms demonstrated thick peripheral enhancement. Three patients in this series had multiple aneurysms, and the unruptured aneurysms did not enhance.…”

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confidence: 99%

Intracranial Vessel Wall MRI: Principles and Expert Consensus Recommendations of the American Society of Neuroradiology

Mandell

Mossa‐Basha

Qiao

et al. 2016

AJNR Am J Neuroradiol

493

456

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SUMMARY:Intracranial vessel wall MR imaging is an adjunct to conventional angiographic imaging with CTA, MRA, or DSA. The technique has multiple potential uses in the context of ischemic stroke and intracranial hemorrhage. There remain gaps in our understanding of intracranial vessel wall MR imaging findings and research is ongoing, but the technique is already used on a clinical basis at many centers. This article, on behalf of the Vessel Wall Imaging Study Group of the American Society of Neuroradiology, provides expert consensus recommendations for current clinical practice. ABBREVIATIONS: RCVS ϭ reversible cerebral vasoconstriction syndrome; VW-MR imaging ϭ vessel wall MR imaging

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Vessel Wall Magnetic Resonance Imaging Identifies the Site of Rupture in Patients With Multiple Intracranial Aneurysms

Abstract: High-resolution MR-VWI identified the site of rupture in patients with aneurysmal SAH, including those patients harboring multiple intracranial aneurysms. It may represent a useful tool in the investigation of aneurysmal SAH.

Cited by 196 publications

References 19 publications

Editorial: Aneurysm wall inflammation

Editorial: Aneurysm wall inflammation

Quantitative Assessment of Circumferential Enhancement along the Wall of Cerebral Aneurysms Using MR Imaging

Intracranial Vessel Wall MRI: Principles and Expert Consensus Recommendations of the American Society of Neuroradiology

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