Vesicular systems in ocular drug delivery: an overview

Kaur, Indu Pal; Garg, Alka B.; Singla, Anil Kumar; Aggarwal, Deepika

doi:10.1016/j.ijpharm.2003.09.016

Cited by 373 publications

(213 citation statements)

References 73 publications

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“…In order to improve ophthalmologic bioavailability of drugs and to prolong the therapeutic action, introduction of novel delivery systems, including vesicular drug delivery systems, like liposomes have recently been proposed (16)(17)(18)(19). Liposomes have investigated since 1970 as a system for the delivery or targeting of drugs to the specific sites in the body.…”

Section: Introductionmentioning

confidence: 99%

Ciprofloxacin as Ocular Liposomal Hydrogel

Hosny

2010

AAPS PharmSciTech

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Abstract. The purpose of this study was to prepare and characterize an ocular effective prolonged-release liposomal hydrogel formulation containing ciprofloxacin. Reverse-phase evaporation was used for preparation of liposomes consisting of soybean phosphatidylcholine (PC) and cholesterol (CH). The effect of PC/CH molar ratio on the percentage drug encapsulation was investigated. The effect of additives such as stearylamine (SA) or dicetyl phosphate (DP) as positive and negative charge inducers, respectively, were studied. Morphology, mean size, encapsulation efficiency, and in vitro release of ciprofloxacin from liposomes were evaluated. For hydrogel preparation, Carbopol 940 was applied. In vitro transcorneal permeation through excised albino rabbit cornea was also determined. Optimal encapsulation efficiency of 73.04±3.06% was obtained from liposomes formulated with PC/CH at molar ratio of 5:3 and by increasing CH content above this limit, the encapsulation decreased. Positively charged liposomes showed superior entrapment efficiency (82.01±0.52) over the negatively charged and the neutral liposomes. Hydrogel containing liposomes with lipid content PC, CH, and SA in molar ratio 5:3:1, respectively, showed the best release and transcorneal permeation with the percentage permeation of 30.6%. These results suggest that the degree of encapsulation of ciprofloxacin into liposomes and prolonged in vitro release depend on composition of the vesicles. In addition, the polymer hydrogel used in preparation ensure steady and prolonged transcorneal permeation. In conclusion, ciprofloxacin liposomal hydrogel is a suitable delivery system for improving the ocular bioavailability of ciprofloxacin.

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Section: Introductionmentioning

confidence: 99%

Ciprofloxacin as Ocular Liposomal Hydrogel

Hosny

2010

AAPS PharmSciTech

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“…Moreover, they are extensively used as lipid carrier similar to liposomes physically, with particular properties, which can be exploited to attain different release characteristics and drug distributions [16]. Preliminary studies indicated that niosomes could prolong the plasma circulation of an entrapped drug and alter its distribution pattern and its metabolic stability [17]. Also, niosomal systems could prolong the contact time of a drug with the applied membranes in case of topical and transdermal applications [18].…”

Section: Liposomes/niosomes and Their Pro-formsmentioning

confidence: 99%

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Ibrahim¹,

Nair²,

Al‐Dhubiab³

et al. 2017

Liposomes

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Polymeric networks that retain and absorb substantial amount of water or biological fluids and resemble as a biological tissue are defined as hydrogels. On the other hand, liposomes, transfersomes and niosomes are lipid carriers, which represent one of the major research and development focus areas of the pharmaceutical industry. They have great potential as lipid vehicles that are able to enhance permeation of drugs across the intact skin and can act as local depot for the drug to sustain and control its delivery. Lipid carrier and hydrogel combinations offer transdermal drug delivery of great potential to enhance systemic effects of both hydrophilic and lipophilic drugs. Also, lipid carriers can target drugs to skin appendages and improve transdermal delivery. Lipid carrier proform systems in the form of gelly liquid crystals can also be used transdermally for better drug absorption enhancement. This review highlights the potential of hydrogels and emulgels with or without lipid nanocarriers for dermal and transdermal application.

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“…Naturalmente, a eficácia de um sistema em exercer atividade biológica com baixa toxicidade não depende 20,21 Dessa maneira os lipossomas são capazes de incrementar a estabilidade dos ácidos nucleicos, diminuindo a sua hidrólise e consequentemente prolongando a sua capacidade de ação. 22 Nanoemulsões consistem em uma dispersão líquido-líquido de dois líquidos imiscíveis entre si e estabilizados por um surfactante, ou sistema surfactante, adequado.…”

Section: Vetores Não Virais Com Base Nanotecnológica Para a Via Ocularunclassified