Vesicular Sézary syndrome with bullous lesions on the feet

A case of bullous Sézary syndrome

“…Bullous Sézary syndrome is even rarer with fewer than 10 cases reported. Bullous lesions may arise in existing lesions of CTCL or as the initial presentation, may be associated with patch, plaque, or tumoral lesions and display a predilection for the torso and extremities [2,[4][5][6][7][8][9][10][11]. Oral mucosal involvement was present in our patient and has been described in one other case of bullous Sézary syndrome [9].…”

“…In patients with bullous mycosis fungoides, approximately 50% died within one year of presentation [2,13]. Of the reported cases of bullous Sézary syndrome, two patients passed away within one year of presentation and one patient was in remission at 15 months although longer term followup was not reported [9][10][11]. This parallels the disease…”

Intra‐lesional interleukin‐2 for the treatment of in‐transit melanoma

“…Most studies are small case reports with inconsistent dosing regimens, intervals, and duration of treatment, and a variety of adjunctive therapies (Table I). In addition, the rates of complete response, partial response, stable disease, and disease progression have been highly inconsistent, ranging from no response or progression in 75% of patients 10 to a complete response of 96% of lesions 11. With such varied responses in outcome, and with a treatment option that appears to be associated with minimal morbidity, our purpose was to document the response of in‐transit metastases to intra‐lesional IL‐2 injection using a consistent regimen in a large series of consecutive patients.…”