Vesicular acetylcholine transporter in the basal forebrain improves cognitive impairment in chronic cerebral hypoperfusion rats by modulating theta oscillations in the hippocampus

Zheng, Jiaxin; Zhu, Hong; Du, Miaoyu; Wang, Zhitian; Lan, Liuyi; Zhang, Junjian

doi:10.1016/j.neulet.2023.137281

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…For the basal forebrain-hippocampus cholinergic neural circuit, acupuncture displayed benign regulation of the molecular metabolism of the medial septal/VDB-DG pathway, which contributed to pattern separation impairment in cognitive impairment ( Li et al, 2022 ). There are bidirectional connections in the basal forebrain-hippocampus projection, of which the hippocampal interneurons receive input from GABAergic neurons and cholinergic neurons and project to the medial septal/VDB in the basal forebrain from the CA1 region ( Zheng et al, 2023 ). In our review, we found that the medial septal/VDB-DG pathway was a modulation target of acupuncture via the cholinergic neural circuit.…”

Section: Discussionmentioning

confidence: 99%

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

Li,

Deng,

Jiang

et al. 2024

Front. Neurosci.

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Neurodegenerative diseases refer to a battery of medical conditions that affect the survival and function of neurons in the brain, which are mainly presented with progressive loss of cognitive and/or motor function. Acupuncture showed benign effects in improving neurological deficits, especially on movement and cognitive function impairment. Here, we reviewed the therapeutic mechanisms of acupuncture at the neural circuit level in movement and cognition disorders, summarizing the influence of acupuncture in the dopaminergic system, glutamatergic system, γ-amino butyric acid-ergic (GABAergic) system, serotonergic system, cholinergic system, and glial cells at the circuit and synaptic levels. These findings can provide targets for clinical treatment and perspectives for further studies.

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Section: Discussionmentioning

confidence: 99%

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

Li,

Deng,

Jiang

et al. 2024

Front. Neurosci.

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Oxidized/unmodified-polyethylene microplastics neurotoxicity in mice: Perspective from microbiota-gut-brain axis

Wang,

Yang,

Shi

et al. 2024

Environment International

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Central Nicotinic and Muscarinic Receptors in Health and Disease

Tizabi¹,

Getachew²,

Tsytsarev³

et al. 2023

Acetylcholine - Recent Advances and New Perspectives

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Without acetylcholine (ACh) no skeletal muscle contraction, no preganglionic sympathetic or parasympathetic activity can be obtained. This can result in dysregulation of cardiac, respiratory, gastrointestinal, and renal functions as well as disruption of fluid secretion from various glands such as tears, saliva, digestive juices, sweat, and milk. Importantly, ACh deficiency in the brain can have severe cognitive consequences. The action of ACh is mediated by two distinct classes of receptors, namely the muscarinic (mAChRs), which are G-protein coupled (metabotropic) receptors and nicotinic receptors (nAChRs), which are ligand-gated ion channels (ionotropic receptors). The focus of this chapter is on interaction of these two distinct receptor classes and its implication in health and disease. Thus, following a brief description of ACh actions and its central circuitry, an update on mAChRs and nAChRs and how their interaction may impact neuropsychiatric/neurodegenerative diseases will be provided. Moreover, potential novel therapeutic intervention based on these interactions, particularly in relationship to Alzheimer’s and Parkinson’s diseases will be touched upon.

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Vesicular acetylcholine transporter in the basal forebrain improves cognitive impairment in chronic cerebral hypoperfusion rats by modulating theta oscillations in the hippocampus

Cited by 3 publications

References 36 publications

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review

Oxidized/unmodified-polyethylene microplastics neurotoxicity in mice: Perspective from microbiota-gut-brain axis

Central Nicotinic and Muscarinic Receptors in Health and Disease

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