Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Kalra, Hina; Simpson, Richard J.; Ji, Hong; Aikawa, Elena; Altevogt, Peter; Askenase, Philip W.; Bond, Vincent C.; Borràs, Francesc E.; Breakefield, Xandra O.; Budnik, Vivian; Buzás, Edit I.; Camussi, Giovanni; Clayton, Aled; Cocucci, Emanuele; Falcón‐Pérez, Juan Manuel; Gabrielsson, Susanne; Gho, Yong Song; Gupta, Dwijendra; Harsha, H. C.; Hendrix, An; Hill, Andrew F.; Inal, Jameel M.; Jenster, Guido; Krämer-Albers, Eva-Maria; Lim, Sai Kiang; Llorente, Alicia; Lötvall, Jan; Marcilla, Antonio; Mincheva‐Nilsson, Lucia; Nazarenko, Irina; Nieuwland, Rienk; Hoen, Esther N. M. Nolte‐‘t; Pandey, Akhilesh; Patel, Tushar; Piper, Melissa G.; Pluchino, ﻿Stefano; Prasad, T. S. Keshava; Rajendran, Lawrence; Raposo, Graça; Record, Michel; Reid, Gavin E.; Sánchez-Madrid, Francisco; Schiffelers, Raymond M.; Siljander, Pia; Stensballe, Allan; Stoorvogel, Willem; Taylor, Douglas D.; Théry, Clotilde; Valadi, Hadi; Balkom, Bas W. M. van; Vázquez, Jesús; Vidal, Michel; Wauben, Marca H. M.; Yáñez-Mó, Marı́a; Zoeller, Margot; Mathivanan, Suresh

doi:10.1371/journal.pbio.1001450

Cited by 1,080 publications

(933 citation statements)

References 43 publications

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“…The field will be expanded by compendia of the molecular content of different types of EVs. Examples of integrated databases providing high-throughput datasets of vesicular components include EVpedia [31], Vesiclepedia [32] and Exocarta [33]. …”

Section: Resultsmentioning

confidence: 99%

Extracellular vesicles: the growth as diagnostics and therapeutics; a survey

Roy

Hochberg

Jones

2018

J of Extracellular Vesicle

105

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This article aims to document the growth in extracellular vesicle (EV) research. Here, we report the growth in EV-related studies, patents, and grants as well as emerging companies with major intent on exosomes. Four different databases were utilized for electronic searches of published literature: two general databases – Scopus/Elsevier and Web of Science (WoS), as well as two specialized US government databases – the USA Patent and Trademark Office and National Institutes of Health (NIH) of the Department of Health and Human Services. The applied combination of key words was carefully chosen to cover the most commonly used terms in titles of publications, patents and grants dealing with conceptual areas of EVs. Within the time frame from 1 January 2000 to 31 December 2016, limited to articles published in English, we identified output using search strategies based upon Scopus/Elsevier and WoS, patent filings and NIH Federal Reports of funded grants. Consistently, USA and UK universities are the most frequent among the top 15 affiliations/organizations of the authors of the identified records. There is clear evidence of upward streaming of EV-related publications. By documenting the growth of the EV field, we hope to encourage a roster of independent authorities skilled to provide peer review of manuscripts, evaluation of grant applications, support of foundation initiatives and corporate long-term planning. It is important to encourage EV research to further identify biomarkers in diseases and allow for the development of adequate diagnostic tools that could distinguish disease subpopulations and enable personalized treatment of patients.

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Section: Resultsmentioning

confidence: 99%

Extracellular vesicles: the growth as diagnostics and therapeutics; a survey

Roy

Hochberg

Jones

2018

J of Extracellular Vesicle

105

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“…This exchange of signals entails either cell-to-cell contacts (juxtacrine) or gradients formed by soluble factors (paracrine) (Friedl et al, 2005) which also circulate in blood and body fluids and act in a regional or systemic manner (endocrine). Stem cell signaling may also involve the newly recognized release of extracellular membrane vesicles (EVs) (Kalra et al, 2012;Mathivanan et al, 2010;Thery et al, 2002). A schematic representation of the alternative cell signaling pathways regulating the interactions between the stem cell graft and the host immune system in inflammatory brain diseases is shown in Figure 3.…”

Section: Stem Cell Signaling and Regulation Of The Host Immune Responsesmentioning

confidence: 99%

“…Some recent evidence suggests that different cell types, including MSCs, traffic complex suites of proteins and non-coding regulatory RNAs (Collino et al, 2010;Kalra et al, 2012;Koh et al, 2010)-which appear to be regulated by extracellular signals that mimic changes in the environment, including Wnts, cytokines, hypoxia and growth factor deprivation (Cossetti et al, 2012b). Current efforts are focusing on establishing the specificity versus reactivity of the vesicle content, as recent studies have suggested that certain patterns of extracellular miRs might not mirror the cellular miRome, but rather, being epiphenomenal to cellular machinery, regulating the mobility of small nucleic acids outside the cell via recycling vesicles (Kalra et al, 2012).…”

Section: Signaling Through Extracellular Membrane Vesiclesmentioning

confidence: 99%

“…Current efforts are focusing on establishing the specificity versus reactivity of the vesicle content, as recent studies have suggested that certain patterns of extracellular miRs might not mirror the cellular miRome, but rather, being epiphenomenal to cellular machinery, regulating the mobility of small nucleic acids outside the cell via recycling vesicles (Kalra et al, 2012).…”

Section: Signaling Through Extracellular Membrane Vesiclesmentioning

confidence: 99%

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How stem cells speak with host immune cells in inflammatory brain diseases

Pluchino

Cossetti

2013

Glia

Self Cite

107

108

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Advances in stem cell biology have raised great expectations that diseases and injuries of the central nervous system (CNS) may be ameliorated by the development of non-hematopoietic stem cell medicines. Yet, the application of adult stem cells as CNS therapeutics is challenging and the interpretation of some of the outcomes ambiguous. In fact, the initial idea that stem cell transplants work only via structural cell replacement has been challenged by the observation of consistent cellular signaling between the graft and the host. Cellular signaling is the foundation of coordinated actions and flexible responses, and arises via networks of exchanging and interacting molecules that transmit patterns of information between cells. Sustained stem cell graft-to-host communication leads to remarkable trophic effects on endogenous brain cells and beneficial modulatory actions on innate and adaptive immune responses in vivo, ultimately promoting the healing of the injured CNS. Among a number of adult stem cell types, mesenchymal stem cells (MSCs) and neural stem/precursor cells (NPCs) are being extensively investigated for their ability to signal to the immune system upon transplantation in experimental CNS diseases. Here, we focus on the main cellular signaling pathways that grafted MSCs and NPCs use to establish a therapeutically relevant cross talk with host immune cells, while examining the role of inflammation in regulating some of the bidirectionality of these communications. We propose that the identification of the players involved in stem cell signaling might contribute to the development of innovative, high clinical impact therapeutics for inflammatory CNS diseases.

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“…Since the final destination of artificial EVs would be the administration for therapeutic purposes, the highest level of standards would be required in order to preserve patient safety [27,43]. A key point in artificial EVs development is the enrichment from different biological samples, from cell-culture supernatants to several body fluids.…”

Section: Semi-synthetic Exosomes: Biotechnological Modification Of Namentioning

confidence: 99%

Therapeutic biomaterials based on extracellular vesicles: classification of bio‐engineering and mimetic preparation routes

García‐Manrique

Matos

Gutiérrez

et al. 2018

J of Extracellular Vesicle

133

139

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Extracellular vesicles (EVs) are emerging as novel theranostic tools. Limitations related to clinical uses are leading to a new research area on design and manufacture of artificial EVs. Several strategies have been reported in order to produce artificial EVs, but there has not yet been a clear criterion by which to differentiate these novel biomaterials. In this paper, we suggest for the first time a systematic classification of the terms used to build up the artificial EV landscape, based on the preparation method. This could be useful to guide the derivation to clinical trial routes and to clarify the literature. According to our classification, we have reviewed the main strategies reported to date for their preparation, including key points such as: cargo loading, surface targeting strategies, purification steps, generation of membrane fragments for the construction of biomimetic materials, preparation of synthetic membranes inspired in EV composition and subsequent surface decoration.

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Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Abstract: Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.

Cited by 1,080 publications

References 43 publications

Extracellular vesicles: the growth as diagnostics and therapeutics; a survey

Extracellular vesicles: the growth as diagnostics and therapeutics; a survey

How stem cells speak with host immune cells in inflammatory brain diseases

Therapeutic biomaterials based on extracellular vesicles: classification of bio‐engineering and mimetic preparation routes

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