Vesical diverticula: Etiology, diagnosis, tumorigenesis, and treatment

Melekos, Michael D.; Asbach, H. W.; Barbalias, George A.

doi:10.1016/0090-4295(87)90378-5

Cited by 98 publications

(54 citation statements)

References 14 publications

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“…Vesical tumors occurring in diverticula pose a difficult treatment problem because of their generally poor prognosis, which is mainly due to difficulty in diagnosis [9] and early invasion [2,3]. In our patient as well as in other publications [9], the CT was unable to distinguish between an exophytic growing bladder tumor and an extravesical mass.…”

Section: Commentmentioning

confidence: 52%

“…The lack of muscle fibers in a diverticulum may allow the tumor to invade earlier and more easily than in normal thick bladder muscle [2][3][4][5][6][7][8][9][10]. Since the pathological stage is the best predictor of survival in bladder carcinosarcoma [7], it seems clear that its presence in a bladder diverticulum would be a bad prognostic factor [4][5][6]10].…”

Section: Commentmentioning

confidence: 99%

“…In 1883 Williams [1] presented the autopsy findings of a sarcoma as the first recorded case of malignancy within a vesical diverticulum; since that time, the incidence of neoplasms in a vesical diverticula has varied from 1.3 to 10% depending on the different published series [2,3]. Carcinosarcoma of the urinary bladder is a very unusual malignancy characterized by an intimate mixture of malignant epithelial elements (carcinoma) and malignant soft tissue elements (sarcoma).…”

Section: Introductionmentioning

confidence: 99%

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Carcinosarcoma in a Bladder Diverticulum

Escandón¹,

García

Argüelles³

et al. 2000

Urol Int

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Carcinosarcoma of the bladder is a rare neoplasm composed of a mixture of malignant epithelial and mesenchymal components. The presentation and clinical course of an infiltrating carcinosarcoma located in a bladder diverticulum coexisting with prostatic adenocarcinoma in a 69-year-old man are described. We believe this to be the fifth report of true carcinosarcoma appearing in a bladder diverticulum.

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Section: Commentmentioning

confidence: 52%

Section: Commentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Carcinosarcoma in a Bladder Diverticulum

Escandón¹,

García

Argüelles³

et al. 2000

Urol Int

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“…CBD are not commonly found in children -an incidence of 1.7% was reported in a series of cases diagnosed by voiding cystourethrogram (VCUG) [3] -but when they are found, they are seen more commonly in boys, with a predominance of 9:1 [4,5]. The exact etiology of CBD is not known, but they are thought to be formed by a primary defect in the Waldeyer fascia, which may be combined with an intrinsic weakness in the bladder wall [1,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…The exact etiology of CBD is not known, but they are thought to be formed by a primary defect in the Waldeyer fascia, which may be combined with an intrinsic weakness in the bladder wall [1,6,7]. Diverticula are often asymptomatic and discovered accidentally during an examination for other health problems [3,8]; however, some patients may present with urinary tract infections, obstructions, hematuria, gallstones, dysfunctional voiding and frequent voiding [5,8,9]. Most CBD can be found in single, unilateral, and paraureteral/posterolateral locations [9].…”

Section: Introductionmentioning

confidence: 99%

Bilateral large congenital periureteral bladder diverticula in a child: A case report

Öztürk¹,

Dağıstan²,

Özyalvaçlı³

2015

PUCR

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Congenital bladder diverticula (CBD) are an outpouching of the mucosa through the muscular wall of the bladder. Large CBD may be presented with a serious urological problem in childhood. A 6-year-old boy was admitted with the complaint of recurrent urinary tract infection and urinary retention. Voiding cystourethrogram revealed a bilateral large CBD. Cystoscopy was performed before surgery to rule out bladder neck pathology, for direct visualization of diverticula, and to see the opening of the ureters. Transvesical diverticulectomy is a reliable technique for surgical treatment, if necessary, and can effectively be combined with the management of associated other pathology.

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Detection of HPV infection in urothelial carcinoma using RNAscope: Clinicopathological characterization

et al. 2021

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Background Human papillomavirus (HPV) is a well‐established mucosotropic carcinogen, but its impact on urothelial neoplasm is unclear. We aimed to clarify the clinical and pathological features of HPV‐related urothelial carcinoma (UC). Methods Tissue samples of 228 cases of UC were obtained from the bladder, upper and lower urinary tract, and metastatic sites to construct a tissue microarray. The samples were analyzed for the presence of HPV by a highly sensitive and specific mRNA in situ hybridization (RISH) technique (RNAscope) with a probe that can detect 18 varieties of high‐risk HPV. We also conducted immunohistochemistry (IHC) for a major HPV capsid antibody and DNA‐PCR. Results The HPV detection rates varied among the methods; probably due to low HPV copy numbers in UC tissues and the insufficient specificity and sensitivity of the IHC and PCR assays. The RISH method had the highest accuracy and identified HPV infection in 12 (5.2%) of the cases. The histopathological analysis of the HPV‐positive UC showed six cases of usual type UC, five cases of UC with squamous differentiation (UC_SqD), and one case of micropapillary UC. The HPV detection rate was six‐fold higher in the cases of UC_SqD than in the other variants of UC (odds ratio [OR] =8.9, p = 0.002). In addition, HPV infection showed a significant association with tumor grade (OR =9.8, p = 0.03) and stage (OR =4.7, p = 0.03) of UC. Moreover, the metastatic rate was higher in HPV‐positive than in negative UC (OR =3.4). Conclusion These data indicate that although the incidence of HPV infection in UC is low, it is significantly associated with squamous differentiation and poor prognosis. Furthermore, our observations show that RNAscope is an ideal method for HPV detection in UC compared with the other standard approaches such as IHC and PCR assays.

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Vesical diverticula: Etiology, diagnosis, tumorigenesis, and treatment

Cited by 98 publications

References 14 publications

Carcinosarcoma in a Bladder Diverticulum

Carcinosarcoma in a Bladder Diverticulum

Bilateral large congenital periureteral bladder diverticula in a child: A case report

Detection of HPV infection in urothelial carcinoma using RNAscope: Clinicopathological characterization

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