Very young women (&lt;35 years) with operable breast cancer: features of disease at presentation

Colleoni, Marco; Rotmensz, Nicole; Robertson, Chris; Orlando, Laura; Viale, Giuseppe; Renne, Giuseppe; Luini, Alberto; Veronesi, Giulia; Intra, Mattia; Orecchia, Roberto; Catalano, Gianpiero; Galimberti, Viviana; Nolè, Franco; Martinelli, Giovanni; Goldhirsch, Aron

doi:10.1093/annonc/mdf039

Cited by 336 publications

(250 citation statements)

References 40 publications

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“…4,[12][13][14] The histological subtype in 91.5% of cases in this study was of invasive ductal morphology. This is in line with Maru's report that invasive ductal carcinoma is the most common histological type of breast cancer in young women.…”

Section: Discussionmentioning

confidence: 60%

Expression of basal keratins and vimentin in breast cancers of young women correlates with adverse pathologic parameters

et al. 2008

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Previous studies have suggested that breast cancer in young women has more aggressive biological features and poorer prognosis. However, the role of biological markers in these patients is not well understood. We aimed to learn more about this disease in a cohort of 125 young women from Singapore, Japan and Hong Kong, aged 35 years or less, with invasive breast cancer by evaluating the expression of vimentin and the basal cytokeratins CK14, CK5/6 and 34bE12. Both standard paraffin sections and tissue microarrays were used in the immunohistochemical evaluation of expression patterns of these four biological markers. CK5/6, CK14, vimentin and 34bE12, in increasing order of proportion, were detected in invasive carcinomas. Basal cytokeratins and vimentin showed significant inverse relationship with estrogen and progesterone receptor status while CK14 expression was found to be directly associated with c-erbB2 status. Basal cytokeratins and vimentin immunoreactivities were directly associated with CD117 and EGFR expression. Vimentin and 34bE12 immunopositivity correlated with tumor size, while vimentin was associated with higher histological grade. Our findings are in concert with reports that expression of basal cytokeratins and vimentin is correlated with adverse pathological parameters.

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Section: Discussionmentioning

confidence: 60%

Expression of basal keratins and vimentin in breast cancers of young women correlates with adverse pathologic parameters

et al. 2008

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“…Vascular invasion (lymphatic and/ or blood vessels) showed a progressive reduction with increasing age in their study, too, like the current survey. In a study done by Colleoni et al (2002), women younger than 35 years had more vascular or lymphatic invasion compared to those 35-50 years. But, no trends with age were observed for pathological stage according to TNM in their study.…”

Section: Discussionmentioning

confidence: 96%

“…Also, subjects were stratified into five age groups: ≤40 years, 41-50 years, 51-60 years, 61-70 years, and 71≤ years. Cut-off age for young women has varied from 35-40 years in some studies (Fisher et al,1997;Colleoni et al, 2002;Harirchi et al, 2011). We selected 40 years or under, since it provided a group of reasonable size which was compatible with other studies.…”

Section: Methodsmentioning

confidence: 99%

Trends in Epidemiology, Clinical and Histopathological Characteristics of Breast Cancer in Iran: Results of a 17 Year Study

Afsharfard

Mozaffar²,

Orang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Lower stages (0 and I) were more frequent among the oldest patients while nearly 50% of patients aged ≤40 had tumor stage III. We also observed a significant decreasing trend in the mean LN count (p<0.05) and blood vessel invasion (p=0.023) from younger to older age groups. Conclusions: More aggressive disease for younger age groups, earlier peak incidence age and high rate of advanced BC at the time of diagnosis among Iranian women, were the main findings of this study.

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“…Breast cancers in young women are more likely to be hormone receptor-negative and of higher grade (Colleoni et al, 2002). In addition, HER2-positive disease is more common in young women.…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer in Young Women from a Low Risk Population in Nepal

Thapa¹,

Singh²,

Sayami³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Very young women (<35 years) with operable breast cancer: features of disease at presentation

Cited by 336 publications

References 40 publications

Expression of basal keratins and vimentin in breast cancers of young women correlates with adverse pathologic parameters

Expression of basal keratins and vimentin in breast cancers of young women correlates with adverse pathologic parameters

Trends in Epidemiology, Clinical and Histopathological Characteristics of Breast Cancer in Iran: Results of a 17 Year Study

Breast Cancer in Young Women from a Low Risk Population in Nepal

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