Very Low Incidence of SARS-CoV-2, Influenza and RSV but High Incidence of Rhino-, Adeno- and Endemic Coronaviruses in Children With Acute Respiratory Infection in Primary Care Pediatric Practices During the Second and Third Wave of the SARS-CoV-2 Pandemic

Engels, Geraldine; Sack, Johanna; Weißbrich, Benedikt; Hartmann, Katrin; Knies, Kerstin; Härtel, Christoph; Streng, Andrea; Dölken, Lars; Liese, Johannes G.

doi:10.1097/inf.0000000000003460

Cited by 23 publications

(24 citation statements)

References 18 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This percentage was significantly lower when compared to the one found in the same time period in 2018–2019 (54.1%); p < 0.001. This is in the range of the results from other studies, which have reported from 15% to 68% of viral detections within their samples [ 8 , 9 , 26 ]. The difference between periods can easily be explained by the fact that, during the pandemic, oropharyngeal or nasopharyngeal samples were collected from most children attending the hospital, while during the pre-pandemic period only children with acute respiratory infection were tested.…”

Section: Discussionsupporting

confidence: 75%

“…These preventive measures useful in containing COVID-19 transmission were not specific to SARS-CoV-2 and seemed to affect the circulation of other respiratory viruses. Many countries have reported changes in viral seasonality during the pandemic, with the disappearance, among others, of enveloped viruses, such as influenza or respiratory syncytial virus (RSV) [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Non-enveloped viruses, including rhinovirus or adenovirus, kept circulating during the pandemic.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Change on the Circulation of Respiratory Viruses and Pediatric Healthcare Utilization during the COVID-19 Pandemic in Asturias, Northern Spain

Garcia-Garcia¹,

Rodríguez-Pérez

Melón

et al. 2022

Children

View full text Add to dashboard Cite

(1) Background: The COVID-19 pandemic and the implementation of restrictions and nonpharmaceutical interventions (NPIs) changed the trends in respiratory viral circulation and the pattern in pediatric healthcare utilization; (2) Methods: A retrospective, multicenter observational study designed to analyze the impact of the pandemic on pediatric healthcare utilization and the viral circulation pattern in children in a region in Northern Spain was carried out. Viral diagnostics data from all nasal or pharyngeal swabs collected in children in Asturias during the periods of March 2018–September 2019 and March 2020–September 2021 were analyzed, as well as the number of pediatric hospitalizations and emergency visits; (3) Results: A total of 14,640 samples were collected during the pandemic period. Of these, at least one respiratory virus was detected in 2940 (20.1%) while 5568/10,298 samples were positive in the pre-pandemic period (54.1%); p < 0.001. The detection of both enveloped and non-enveloped viruses decreased among periods (p < 0.001). After week 14, 2020, enveloped viruses were no longer detected until one year later, while non-enveloped viruses continued to be detected in children. Overall, a mean of 4946.8 (95% CI 4519.1–5374.4) pediatric emergency visits per month during the period 2018–2019 as compared to 2496.5 (95% CI 2086.4–2906.5) for 2020–2021 occurred (p < 0.001). The mean of pediatric hospitalizations also significantly decreased between periods, as follows: 346.6 (95% CI 313–380.2) in 2018–2019 vs. 161.1 (95% CI 138.4–183.8); p < 0.001; (4) Conclusions: Our study showed a remarkably reduction in pediatric hospitalizations and emergency visits and a change in the pattern of viral circulation during the COVID-19 pandemic in Asturias. The usual seasonal respiratory viruses, namely influenza or RSV were nearly absent in the pediatric population during the pandemic.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Change on the Circulation of Respiratory Viruses and Pediatric Healthcare Utilization during the COVID-19 Pandemic in Asturias, Northern Spain

Garcia-Garcia¹,

Rodríguez-Pérez

Melón

et al. 2022

Children

View full text Add to dashboard Cite

show abstract

“…In a multicentre prospective study of primary care paediatric practices in Germany between November 2020 and April 2021, rhinovirus was the most commonly detected respiratory virus among children with ARI, while SARS-CoV-2 and influenza virus infections were minimally detected 108 . Among children in Thailand seeking care, there was a notable increase in cases of ILI caused by rhinovirus in July 2020, which were replaced by RSV-associated ILI cases later in the season 109 .…”

Section: Respiratory Disease Associated With Non-sars-cov-2 Virusesmentioning

confidence: 99%

The effects of the COVID-19 pandemic on community respiratory virus activity

2022

View full text Add to dashboard Cite

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused substantial global morbidity and deaths, leading governments to turn to non-pharmaceutical interventions to slow down the spread of infection and lessen the burden on health care systems. These policies have evolved over the course of the COVID-19 pandemic, including after the availability of COVID-19 vaccines, with regional and country-level differences in their ongoing use. The COVID-19 pandemic has been associated with changes in respiratory virus infections worldwide, which have differed between virus types. Reductions in respiratory virus infections, including by influenza virus and respiratory syncytial virus, were most notable at the onset of the COVID-19 pandemic and continued in varying degrees through subsequent waves of SARS-CoV-2 infections. The decreases in community infection burden have resulted in reduced hospitalizations and deaths associated with non-SARS-CoV-2 respiratory infections. Respiratory virus evolution relies on the maintaining of a diverse genetic pool, but evidence of genetic bottlenecking brought on by case reduction during the COVID-19 pandemic has resulted in reduced genetic diversity of some respiratory viruses, including influenza virus. By describing the differences in these changes between viral species across different geographies over the course of the COVID-19 pandemic, we may better understand the complex factors involved in community co-circulation of respiratory viruses.

show abstract

“…Reductions in incidence, as well as shifts in timing, have been reported worldwide during the pandemic for other respiratory viruses such as influenza and RSV[40–44]. Resurgences following the subsequent lifting of social distancing measures have also been documented, driven by age-dependent patterns of immunity to different pathogens in a population[45–48]. Here, we identified the co-circulation of multiple respiratory pathogens in this cohort, including SARS-CoV-2, Influenza A, and RSV.…”

Section: Discussionmentioning

confidence: 99%

Metagenomic next-generation sequencing to characterize etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda

Mwakibete

Takahashi

Ahyong

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Causes of non-malarial fevers in sub-Saharan Africa remain understudied. We hypothesized that metagenomic next-generation sequencing (mNGS), which allows for broad genomic-level detection of infectious agents in a biological sample, can systematically identify potential causes of non-malarial fevers. Methods and Findings: The 212 participants in this study were of all ages and were enrolled in a longitudinal malaria cohort in eastern Uganda. Between December 2020 and August 2021, respiratory swabs and plasma samples were collected at 313 study visits where participants presented with fever and were negative for malaria by microscopy. Samples were analyzed using CZ ID, a web-based platform for microbial detection in mNGS data. Overall, viral pathogens were detected at 123 of 313 visits (39%). SARS-CoV-2 was detected at 11 visits, from which full viral genomes were recovered from nine. Other prevalent viruses included Influenza A (14 visits), RSV (12 visits), and three of the four strains of seasonal coronaviruses (6 visits). Notably, 11 influenza cases occurred between May and July 2021, coinciding with when the Delta variant of SARS-CoV-2 was circulating in this population. The primary limitation of this study is that we were unable to estimate the contribution of bacterial microbes to non-malarial fevers, due to the difficulty of distinguishing bacterial microbes that were pathogenic from those that were commensal or contaminants. Conclusions: These results revealed the co-circulation of multiple viral pathogens likely associated with fever in the cohort during this time period. This study illustrates the utility of mNGS in elucidating the multiple causes of non-malarial febrile illness. A better understanding of the pathogen landscape in different settings and age groups could aid in informing diagnostics, case management, and public health surveillance systems.

show abstract

Very Low Incidence of SARS-CoV-2, Influenza and RSV but High Incidence of Rhino-, Adeno- and Endemic Coronaviruses in Children With Acute Respiratory Infection in Primary Care Pediatric Practices During the Second and Third Wave of the SARS-CoV-2 Pandemic

Cited by 23 publications

References 18 publications

Change on the Circulation of Respiratory Viruses and Pediatric Healthcare Utilization during the COVID-19 Pandemic in Asturias, Northern Spain

Change on the Circulation of Respiratory Viruses and Pediatric Healthcare Utilization during the COVID-19 Pandemic in Asturias, Northern Spain

The effects of the COVID-19 pandemic on community respiratory virus activity

Metagenomic next-generation sequencing to characterize etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda

Contact Info

Product

Resources

About