Very low estrogen-desogestrel contraceptive in perimenopausal hormonal replacement

Risk factors for onset of menopausal symptoms

“…Regarding young age at menarche, a lower risk has been previously described [5], but also an absence of association [10], similarly to our study. Our results of a decrease in risk of onset of menopausal symptoms in current OC users are in agreement with three randomized studies of use of OC as treatment of perimenopausal climacteric symptoms [30][31][32]. This may be explained by the compensation of the lack of estrogens experienced in periods surrounding menopause afforded by OC.…”

Use of hormonal contraceptives in perimenopause: A systematic review

“…[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Table 1 includes the key findings of nine studies that evaluated the resolution of perimenopausal symptoms with hormonal contraception. [8][9][10][11][12][13][14][15][16] Table 2 presents seven studies that evaluated long-term outcomes beyond symptoms such as bone loss and metabolic parameters in this population. 10,[17][18][19][20][21][22]…”

“…[8][9][10][11][12][13][14][15][16] Table 2 presents seven studies that evaluated long-term outcomes beyond symptoms such as bone loss and metabolic parameters in this population. 10,[17][18][19][20][21][22]…”

“…Nine studies evaluated the resolution of perimenopausal symptoms with the use of hormonal contraceptives. [8][9][10][11][12][13][14][15][16] These included vasomotor, psychological, sexual, and somatic (headaches, fatigue, muscle and joint pains, feeling dizzy, and numbness) symptoms.…”

“…16 Five studies evaluated the resolution of VMS with hormonal contraceptives in the perimenopausal population. 8,10,11,13,16 One study evaluated the combination of oral conjugated equine estrogen with 20 mcg/24-h LNG-IUD and improved VMS for 84%-86% of women within 6 months. 11 Another study reported that the use of either a 5 mcg/24-h or 10 mcg/24-h LNG-IUD plus oral or transdermal estrogen resulted in all women having VMS relief with no statistical difference between the treatment combinations.…”