Very low and low birth weight associated with maternal periodontitis

Guimarães, Alessandra Neves; Silva-Mato, Agustín; Siqueira, Fernanda Mafra; Cyrino, Renata Magalhães; Cota, Luís Otávio Miranda; Costa, Fernando Oliveira

doi:10.1111/jcpe.12000

Cited by 13 publications

(11 citation statements)

References 49 publications

(120 reference statements)

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“…The association demonstrated between maternal periodontal disease and LBW (Table ) corroborates some previous studies showing that maternal periodontal disease promotes adverse pregnancy outcomes, such as LBW and premature birth . Notwithstanding, other studies have failed to find effects of maternal periodontal disease on birth weights of offspring .…”

Section: Discussionsupporting

confidence: 88%

“…The association demonstrated between maternal periodontal disease and LBW ( Table 2) corroborates some previous studies showing that maternal periodontal disease promotes adverse pregnancy outcomes, such as LBW and premature birth. 13,[30][31][32] Notwithstanding, other studies have failed to find effects of maternal periodontal disease on birth weights of offspring. 14,33 Ide and Papapanou 6 considered this association modest but significant, because in each study there is a high degree of variability in the evaluation of the populations as well as differences in the way the data are recorded and treated.…”

Section: Discussionmentioning

confidence: 99%

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Effect of maternal periodontitis on GLUT4 and inflammatory pathway in adult offspring

Mattera

Chiba²,

Lopes

et al. 2019

Journal of Periodontology

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Background Maternal periodontal disease leads to low birth weight (LBW), insulin resistance (IR), increased TNF‐α levels, and alterations in insulin signaling in adult offspring. TNF‐α has been associated with the stimulation of IKKβ/NF‐κB, resulting in the decreased expression of GLUT4. Another mechanism that may be involved in decreasing GLUT4 expression is DNA methylation. This study aimed to evaluate in the adult offspring of rats with periodontal disease: IR, inflammatory pathways, DNA methylation, and expression of GLUT4. Methods Female Wistar rats were distributed into control and experimental periodontal disease groups. Seven days after induction of periodontal disease, both groups were mated with healthy male rats. After weaning, male offspring were distributed into control offspring (CN‐o) and periodontal disease offspring (PED‐o) groups. Body weights were measured from 0–75 days of age. At day 75, the following were measured in the offspring: IR (HOMA‐IR index); TNF‐α and NF‐κBp65 content in the gastrocnemius muscle (GM) by western blotting; IKKα/β, JNK, ERK 1/2, NF‐κBp65, and NF‐κBp50 phosphorylation status in the GM by western blotting; DNA methylation by restriction digest and real‐time PCR(qAMP); and expression of GLUT4 mRNA in the GM by real‐time PCR. Results LBW, IR, increases in TNF‐α, IKKα/β, ERK 1/2, NF‐κBp65, and NF‐κBp50 decreased expression of GLUT4 mRNA were observed in the PED‐o rats. No differences were identified in JNK phosphorylation status and DNA methylation in the evaluated regions of the GLUT4‐encoding gene Slc2a4. Conclusion Maternal periodontal disease causes LBW, IR, activation of inflammatory pathways, and decreased GLUT4 expression in the GM of adult offspring.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Effect of maternal periodontitis on GLUT4 and inflammatory pathway in adult offspring

Mattera

Chiba²,

Lopes

et al. 2019

Journal of Periodontology

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“…Recent studies have shown an association between periodontitis during pregnancy and low birth weight (LBW), very low birth weight (VLBW), preeclampsia, and GDM (Corbella et al, 2016;Guimarã es et al, 2012;Ha, Jun, Ko, Paik, & Bae, 2014;Xiong et al, 2009). Guimarã es et al (2012 showed in their crosssectional study of 1,206 postpartum women that "maternal periodontitis was associated with a decrease in mean birth weight, as well as LBW and VLBW" (p. 1024).…”

Section: Periodontitismentioning

confidence: 98%

Oral Health in Pregnancy

Hartnett¹,

Haber²,

Krainovich-Miller³

et al. 2016

Journal of Obstetric, Gynecologic & Neonatal Nursing

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Oral health is crucial to overall health. Because of normal physiologic changes, pregnancy is a time of particular vulnerability in terms of oral health. Pregnant women and their providers need more knowledge about the many changes that occur in the oral cavity during pregnancy. In this article we describe the importance of the recognition, prevention, and treatment of oral health problems in pregnant women. We offer educational strategies that integrate interprofessional oral health competencies.

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“…Increased gingival inflammation is well documented during pregnancy (Ehlers et al 2013, Figuero et al 2013, Niederman 2013 while periodontal diseases increase risk for maternal (hypertension and preeclampsia) and fetal complications (low birth weight and pre-term birth) (Marin et al 2005, Guimaraes et al 2012, Pralhad et al 2013, Ha et al 2014, Jacob & Nath 2014, Rao et al 2014. For example, active periodontal inflammation, as determined by bleeding on probing, has been reported to correlate with reductions in fetal femur length, birth weight and birth length ).…”

mentioning

confidence: 99%

Increased infection with key periodontal pathogens during gestational diabetes mellitus

Gogeneni

Buduneli

Ceyhan-Öztürk

et al. 2015

J Clinic Periodontology

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Aim Gestational diabetes mellitus (GDM), gingivitis, infection with specific periodontal pathogens and systemic inflammation each increase the risk for poor pregnancy outcome. We set out to monitor the interactions of gingivitis and GDM with respect to oral infection and the systemic inflammatory burden. Materials and Methods Four case–control groups (n = 117) were recruited, (1) No gingivitis, No GDM (n = 27); (2) Gingivitis, No GDM (n = 31); (3) No gingivitis, GDM (n = 21); and (4) Gingivitis, GDM (n = 38). Oral infection with three key periodontal pathogens was determined by PCR. Systemic inflammation was determined by quantification of CRP by EIA. Results Gingivitis during pregnancy was associated with oral infection with Porphyromonas gingivalis, Filifactor alocis and Treponema denticola and combinations thereof (all p < 0.01). GDM was also associated with increased infection with individual and multiple oral pathogens (all p < 0.05). Gingivitis during pregnancy led to a 325% increase in systemic CRP (mean, 2495 versus 8116 ng/ml, p < 0.01). Conclusions Diabetes and gingivitis act in concert to increase risk biomarkers for poor pregnancy outcome.

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Very low and low birth weight associated with maternal periodontitis

Abstract: Maternal periodontitis was associated with a decrease in mean birth weight, as well as with LBW and VLBW.

Cited by 13 publications

References 49 publications

Effect of maternal periodontitis on GLUT4 and inflammatory pathway in adult offspring

Effect of maternal periodontitis on GLUT4 and inflammatory pathway in adult offspring

Oral Health in Pregnancy

Increased infection with key periodontal pathogens during gestational diabetes mellitus

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