Very Late Amplatzer Device Thrombosis and Stroke

Giraldo-Gonzalez, German Camilo; Olaya, Pastor; Dominguez, Andres; Sánchez, Jairo; Vesga, Carlos

doi:10.1016/j.case.2019.09.008

Cited by 3 publications

(5 citation statements)

References 11 publications

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“…Late thrombosis associated with these devices is a rather unusual complication and is even rarer in the Amplatzer device. Giraldo-Gonzalez ( 5 ) reported a case of a 59-year-old man who presented with disorientation and right hemiparesis 8 years after implantation of the Amplatzer device, in which a left-sided thrombus (14 × 12 mm) attached to the device was identified. After 5 months of anticoagulation therapy treated with low-molecular-weight heparin, the thrombus and neurological symptoms disappeared in this patient.…”

Section: Discussionmentioning

confidence: 99%

Case report: Bi-atrial thrombus after occlusion of atrial septal defect with acute cerebral infarction and pulmonary embolism

Xiong

Wei

et al. 2022

Front. Cardiovasc. Med.

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A 49-year-old man presented to the hospital with symptoms of acute cerebral infarction and pulmonary embolism who underwent transcatheter closure of atrial septal defect a year before. Transthoracic echocardiography showed a 13 × 9 mm hypoechoic mass attached to the left-atrial side of the device, which was suspected to be a neoplasm or thrombus. The patient was indicated for surgery after multidisciplinary discussion due to ineffective medical therapy and typical stroke and pulmonary embolism symptoms. Three-dimensional transesophageal echocardiography (3D-TEE) revealed left-atrial vegetation (21 × 16 mm) and right-atrial vegetation (8 × 6 mm) attached to the device, which was confirmed as thrombus by surgical separation and laboratory examination. This case highlights the importance of 3D-TEE and a multidisciplinary team in the diagnosis and therapy of device-related thrombus.

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Section: Discussionmentioning

confidence: 99%

Case report: Bi-atrial thrombus after occlusion of atrial septal defect with acute cerebral infarction and pulmonary embolism

Xiong

Wei

et al. 2022

Front. Cardiovasc. Med.

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“…Similarly, Camilo et al reported a case of left atrial thrombus with amplatzer septal cccluder after 8 years of implantation in 59 year old patient, which was also resolved with medical therapy as in our case. 8 Olawale et al also reported a case of late thrombus formation on an amplatzer septal occluder device after 3 years of implantation in a 13 year old girl. 6 There are cases of such very late ASD device thrombosis (5-6 years) with other intra-atrial septal occluder as well.…”

Section: Case Reportmentioning

confidence: 95%

“…Although only few cases of late thrombosis (>1 year) of ASD devices have been reported, it need prevention to prove long-term safety of these devices. 2,3,[5][6][7][8][9][10] In a study involving 407 patients with ASD which were closed using different occluders, Krumsdorf et al found amplatzer septal occluder as less thrombogenic than other device. 11 In a systemic review which included 17 case reports, thrombosis was reported in all currently used devices, but showed lower incidence with new generation devices such as amplatzer septal occluder.…”

Section: Case Reportmentioning

confidence: 99%

“…11 In a systemic review which included 17 case reports, thrombosis was reported in all currently used devices, but showed lower incidence with new generation devices such as amplatzer septal occluder. 8 However, majority of studies evaluated patients up to 1-2 years after device deployment and most of the thrombi resolved with antiplatelet and/or anticoagulation therapy by that time. The present case reported occurrence of late thrombosis, after 5 years, in a female who had undergone ASD closure with amplatzer septal occluder device.…”

Section: Case Reportmentioning

confidence: 99%

“…However, the very long-term safety of these devices is still a question that needs answer. Although only few cases of late thrombosis (>1 year) of ASD devices have been reported, it need prevention to prove long-term safety of these devices 2,3,[5][6][7][8][9][10].…”

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confidence: 99%

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Very late (>5 years) thrombus formation on an atrial septal defect device: a case report

Bolinera¹,

Soma²,

Reddy³

et al. 2020

Int J Res Med Sci

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Though percutaneous transcatheter atrial septal defect closure with newer generation occluder devices is a standard treatment at present, these devices have significant long-term risks (>1 year) associated with such as thrombus formation. Here, we present a case of 28 year-old patient presented with few symptoms and had a history of ASD device closure using amplatzer septal occluder device five years back. The patient was found to have a large thrombus (30×33 mm) attached to the device which was managed using anticoagulants and patients was advised for regular echocardiographic follow-up.

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Long-term follow-up of percutaneous secundum-type atrial septal defect closure using Amplatzer Septal Occluder since 1995: a single-centre study

Olejnik,

Tittel,

Venczelova

et al. 2023

Cardiol Young

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Introduction: The goal of this single-centre study was to evaluate long-term results of percutaneous closure of secundum-type atrial septal defect using Amplatzer Septal Occluder with the follow-up to 25 years. Methods: A retrospective analysis of patients who underwent percutaneous closure of secundum-type atrial septal defect between September 1995 and October 2012 in our institution was performed. All procedures were performed after fulfilling strict indication criteria. More than 5 years follow-up was reached in 651/803 patients (81%) with median follow-up time of 12 (5–25) years. Results: The mean stretched defect diameter was 14,0 ± 5,2 mm. Early reintervention due to moderate or severe residual atrial septal defect had to be performed in 3/803 patients (0,03%). The incidence of long-term moderate or severe residual atrial septal defect was 0,0%. The complete closure rate at 10-year follow-up was 98,5%, as trivial residual shunts persisted in 8/508 patients (1,5%). A significant rate of the echocardiographic right ventricular end-diastolic diameter post-procedural normalisation (p < 0,05) was encountered. The rate of major complications was 0,5%. One device embolisation, one thrombus formation at the occluder surface, and one cardiac erosion in periprocedural or short post-procedural course were experienced. Only one late complication of infective endocarditis at the region of implanted occluder and the aortic valve was detected. The survival rate of all followed patients was 100%. Conclusions: Percutaneous closure of secundum-type atrial septal defect using Amplatzer Septal Occluder is a safe and effective procedure accounting for a very low incidence of major complications in the long-term follow-up.

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Very Late Amplatzer Device Thrombosis and Stroke

Cited by 3 publications

References 11 publications

Case report: Bi-atrial thrombus after occlusion of atrial septal defect with acute cerebral infarction and pulmonary embolism

Case report: Bi-atrial thrombus after occlusion of atrial septal defect with acute cerebral infarction and pulmonary embolism

Very late (>5 years) thrombus formation on an atrial septal defect device: a case report

Long-term follow-up of percutaneous secundum-type atrial septal defect closure using Amplatzer Septal Occluder since 1995: a single-centre study

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