Very Early-onset Schizophrenia with Secondary Onset Tic Disorder

Telgote, Shilpa Avinash; Pendharkar, Shreyas Shrikant; Kelkar, Amol; Bhojane, Sachin

doi:10.4103/0253-7176.211739

Cited by 2 publications

(1 citation statement)

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“…Documented initial diagnostic consideration for new adult-onset tic-like sounds includes a number of distinct conditions that must be excluded. Additionally, the presence of vocal tics as a symptomatic manifestation of schizophrenia has been implied in previous literature [ 4 ], as there are limited clinical evidential reports on tics and tic-like episodes. The absence of any known baseline significant premorbid abnormalities in language, motor skill, or social development while growing up also makes this case report unique.…”

Section: Discussionmentioning

confidence: 99%

Clozapine Response for Vocal Tics in Schizophrenic Patients: A Case Report With Literature Review

Begum¹,

Nkemjika²,

Olayinka³

et al. 2021

Cureus

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Antipsychotics have been documented in the literature as the most effective pharmacological treatment for tics thus far. Additionally, evidence in the literature has shown that typical and atypical antipsychotics are effective for the treatment of tic disorders in patients who are diagnosed with schizophrenia and other psychiatric illnesses. This evidence is typified as atypical antipsychotic medications, such as risperidone, aripiprazole, and olanzapine, have been documented as being effective for motor tics, particularly in Tourette’s syndrome. Despite the level of evidence with regard to antipsychotics, there is no published literature on the role of clozapine-based treatment for persistent vocal tics in schizophrenia. We present a case of severe adult-onset persistent vocal tics in a schizophrenic patient who was admitted for acute psychotic exacerbation. The patient's vocal tics as well as his comorbid psychotic symptoms were not responsive to risperidone and paliperidone. The combination of risperidone with clozapine for psychosis showed improvements in his symptoms. In addition, the patient’s tics showed excellent response to risperidone and clozapine combination therapy. He was subsequently discharged to the community with clozapine 125 mg twice daily and paliperidone palmitate 156 mg every 28 days. The patient was psychiatrically stable without vocalization at the time of discharge. We suggest that clozapine augmentation therapy could be an approach in treatment-resistant vocal tics among schizophrenic patients who are refractory to atypical antipsychotics.

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Section: Discussionmentioning

confidence: 99%

Clozapine Response for Vocal Tics in Schizophrenic Patients: A Case Report With Literature Review

Begum¹,

Nkemjika²,

Olayinka³

et al. 2021

Cureus

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The Transdiagnostic Relevance of Self-Other Distinction to Psychiatry Spans Emotional, Cognitive and Motor Domains

Eddy

2022

Front. Psychiatry

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Self-other distinction refers to the ability to distinguish between our own and other people's physical and mental states (actions, perceptions, emotions etc.). Both the right temporo-parietal junction and brain areas associated with the human mirror neuron system are likely to critically influence self-other distinction, given their respective contributions to theory of mind and embodied empathy. The degree of appropriate self-other distinction will vary according to the exact social situation, and how helpful it is to feel into, or remain detached from, another person's mental state. Indeed, the emotional resonance that we can share with others affords the gift of empathy, but over-sharing may pose a downside, leading to a range of difficulties from personal distress to paranoia, and perhaps even motor tics and compulsions. The aim of this perspective paper is to consider how evidence from behavioral and neurophysiological studies supports a role for problems with self-other distinction in a range of psychiatric symptoms spanning the emotional, cognitive and motor domains. The various signs and symptoms associated with problematic self-other distinction comprise both maladaptive and adaptive (compensatory) responses to dysfunction within a common underlying neuropsychological mechanism, compelling the adoption of more holistic transdiagnostic therapeutic approaches within Psychiatry.

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Very Early-onset Schizophrenia with Secondary Onset Tic Disorder

Cited by 2 publications

References 13 publications

Clozapine Response for Vocal Tics in Schizophrenic Patients: A Case Report With Literature Review

Clozapine Response for Vocal Tics in Schizophrenic Patients: A Case Report With Literature Review

The Transdiagnostic Relevance of Self-Other Distinction to Psychiatry Spans Emotional, Cognitive and Motor Domains

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