Very Bright Dorsal Columns

Wiendl, Heinz; Strayle-Batra, Marion; Schulz, Jörg B.

doi:10.1001/archneur.59.1.147

Cited by 4 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No similar symmetric hyperintense MRI lesions of the spinal cord of dogs have been reported. In people, T2W hyperintense symmetric lesions of the cervical spinal cord have been associated with cobalamin deficiency (subacute combined degeneration), copper deficiency, Wallerian degeneration, amyotrophic lateral sclerosis, spinocerebellar atrophy, poliomyelitis (affecting mainly gray matter), AIDS myelitis, and multiple sclerosis 20–24 . The signal intensity changes are caused by demyelination, Wallerian degeneration, and gliosis 24 .…”

Section: Discussionmentioning

confidence: 99%

A Novel Leukoencephalomyelopathy of Leonberger Dogs

Oevermann

Bley

Konar

et al. 2008

Veterinary Internal Medicne

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

A Novel Leukoencephalomyelopathy of Leonberger Dogs

Oevermann

Bley

Konar

et al. 2008

Veterinary Internal Medicne

View full text Add to dashboard Cite

“…The treatment of elevated free homocysteine levels with folate reduces the risk of thrombosis and other vascular diseases [3]. However, it remains speculative, whether the pelvic thrombosis of our patient may be attributed to the markedly increased homocysteine level, since total homocysteine was and free homocysteine levels were considerably lower.…”

mentioning

confidence: 69%

“…The clinical symptoms, the appearance of the cervicothoracic lesion on MRI [3], Hunter's glossitis, and the macrocytemia led to the diagnosis of funicular myelosis despite a normal vitamin B12 serum level. The reason for the normal vitamin B12 serum level but metabolic vitamin B12 deficiency in our patient was not investigated.…”

mentioning

confidence: 99%

Clinically and MRI documented funicular myelosis in a patient with metabolical vitamin B12 deficiency but normal vitamin B12 serum level

Lorenzl¹,

Vogeser²,

Müller-Schunk

et al. 2003

J Neurol

View full text Add to dashboard Cite

Sirs: Funicular myelosis is a subacute degeneration of the dorsal columns of the spinal cord that is associated with vitamin B12 deficiency. Early treatment reverses pathological changes in the spinal cord and prevents long-term disability. However, some assays currently in use have too low a diagnostic sensitivity and specificity to serve as the sole criterion for vitamin B12 deficiency. Therefore, the vitamin B12-dependent decomposition products methylmalonyl acid and homocysteine, which are metabolized in the two vitamin B12-dependent reactions in humans, were introduced several years ago as a very sensitive test for vitamin B12 deficiency [1, 2]. Here we describe a 66-year-old woman who had metabolic vitamin B12 deficiency but normal vitamin B12 serum levels and developed clinically and MRI-documented funicular myelosis.The 66-year-old woman was admitted with a 3 months history of ataxia of stance and gait. Neurological examination revealed a lowgrade spastic tetraparesis with no vibration sense or feeling of pain and temperature below the T 6 level, and marked ataxia. The deep tendon reflexes were increased (+ + +) and symmetric; a Babinski sign was elicited in the right foot. The results of heel-to-knee testing were normal. The patient was unable to walk with a tandem gait and had a tendency to veer to the right when walking. In addition, her tongue was smooth (Hunter's glossitis was suspected), and she reported a burning sensation in her throat of almost 6 months' duration. There was no apparent cognitive decline. Repeated lumbar puncture revealed normal cerebrospinal fluid without any sign of infection. Blood tests revealed 3.53 µIU erythrocyte count (normal values 3.8-5.8), 12.7 g/dL hemoglobin (12-16), 37 % hematocrit (35-47 %), mean corpuscular volume 107.5 fL (78-98), and mean corpuscular hemoglobin 36.0 (27-34). Mild macrocytemia due to vitamin B12 deficiency was suspected, but her vitamin B12 serum level was 338 ng/L (reference range 160-925 ng/L). Repeated determination of vitamin B12 revealed normal values (312 ng/L and 298 ng/L, respectively). Magnetic resonance imaging (MRI) of the head was normal. However, MRI of the spine showed a hyperintensity on T2-weighted images of the dorsal cervical and thoracic spinal cord (Fig.

show abstract

Spinal cord lesions in patients with neuromyelitis optica: a retrospective long-term MRI follow-up study

et al. 2009

View full text Add to dashboard Cite

Neuromyelitis optica (NMO) is characterised by a particular pattern of the optic nerves and the spinal cord. Long-term MRI follow-up studies of spinal NMO lesions are rare, or limited by short observation periods. In nine patients with definite NMO or recurrent longitudinally extensive transverse myelitis (LETM) with NMO-IgG serum antibodies, repeated MRI examinations of the spine were carried out over a period of up to 11 years and evaluated regarding the changes over time in this retrospective study. In eight patients spinal cord lesions were located centrally, involving the grey and white matter. In the first examination after clinical onset changes resembled a stroke of the anterior spinal artery in two patients. Symmetrical signal alterations within the grey matter were observed. In one patient this pattern was transient, but it remained in the other. During the chronic stage, either a variable degree of spinal cord atrophy and high signal alterations, or almost complete remission of the lesions, was observed. Spinal MRI of patients with NMO myelitis can resemble a stroke. MRI of acute NMO stages did not allow a prediction of the clinical outcome. To a variable degree, NMO left behind typical defects which correlated with the clinical outcome.

show abstract

Very Bright Dorsal Columns

Cited by 4 publications

References 2 publications

A Novel Leukoencephalomyelopathy of Leonberger Dogs

A Novel Leukoencephalomyelopathy of Leonberger Dogs

Clinically and MRI documented funicular myelosis in a patient with metabolical vitamin B12 deficiency but normal vitamin B12 serum level

Spinal cord lesions in patients with neuromyelitis optica: a retrospective long-term MRI follow-up study

Contact Info

Product

Resources

About