Vertical Transmission of Mycoplasma pneumoniae Infection

Huber, Benedikt M.; Sauteur, Patrick M. Meyer; Unger, Wendy W.J.; Hasters, Paul; Eugster, Marcel R.; Brandt, Simone; Bloemberg, Guido V.; Natalucci, Giancarlo; Berger, Christoph

doi:10.1159/000490610

Cited by 11 publications

(11 citation statements)

References 19 publications

(21 reference statements)

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“…Since Hofbauer cells are localized in villi, they have been implicated in the spread of some infections, such as Zika or HIV-1 [ 43 ]. Less information is available about mycoplasma vertical transmission, although congenital infections in newborns are associated with the presence of mycoplasma in placental tissues [ 44 , 45 ]. As of this date, precise data on the vertical transmission of the SARS-CoV-2 virus in pregnant women has not yet become available.…”

Section: The Placenta and The Possibilities Of Vertical Transmission In Emerging Diseases Like Sars-cov-2 Virus Zika Virus And Mycoplasmamentioning

confidence: 99%

“…However, various mycoplasmas can disseminate through the bloodstream during or after a respiratory tract infection and spread to the placenta. Interestingly, vertical transmission cases of invasive M. pneumoniae are relatively rare [ 45 ]. However, certain associations between M. pneumoniae during pregnancy and hematological complications, such as hemolytic anemia, are among the most common pregnancy complications.…”

Section: Sars-cov-2 Zika and Mycoplasma Presentation During Pregnancy And Its Pathophysiological And Molecular Correlationsmentioning

confidence: 99%

See 1 more Smart Citation

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Ferreira

Blasina

Rey

et al. 2022

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.

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Section: The Placenta and The Possibilities Of Vertical Transmission In Emerging Diseases Like Sars-cov-2 Virus Zika Virus And Mycoplasmamentioning

confidence: 99%

Section: Sars-cov-2 Zika and Mycoplasma Presentation During Pregnancy And Its Pathophysiological And Molecular Correlationsmentioning

confidence: 99%

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Ferreira

Blasina

Rey

et al. 2022

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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“…M. pneumoniae . Se trata de un patógeno exclusivamente humano [ 135 ]. Sus manifestaciones clínicas se producen mayoritariamente a nivel del tracto respiratorio, las extrapulmonares no son raras y con frecuencia graves.…”

Section: Especies Implicadas En Patología Humanaunclassified

Clinical implications of the genus Mycoplasma

Rufo¹,

Sánchez²,

Sánchez³

et al. 2021

Rev Esp Quimioter

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Within Mycoplasma genus, M. pneumoniae, M. genitalium, M. hominis or U. urealyticum are the main species that have been traditionally linked to infectious processes. However, there are many other species involved in these conditions and that are, frequently, unfamiliar to healthcare professionals. The aim of this review is to identify all Mycoplasma genus species that have been isolated in human beings and to determine their involvement in infectious pathology.

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“…Its high incidence and rapid progress are important causes of death in children under five years old (2)(3)(4). Worldwide, two million children die of neonatal IPN every year, accounting for 5% to 35% of neonatal autopsies (5). As the initial clinical symptoms and signs of the disease are not obvious, the diagnosis is difficult, resulting in delay of the disease, resulting in a high mortality rate.…”

Section: Introductionmentioning

confidence: 99%

Assessment of mechanisms of infectious pneumonia based on expression of fibrinogen, procalcitonin, high-sensitivity C-reactive protein expression, T helper 17 cells, regulatory T cells interleukin-10, and interleukin-17

Zu¹,

Zhang²

2022

Transl Pediatr

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Background: Infectious pneumonia is one of the important causes of neonatal death that can lead to the imbalance of T helper 17 cells (Th17) and T regulatory T cells (Treg) cells. The correlation between plasma fibrinogen (FIB), procalcitonin (PCT), C-reactive protein (CRP) and Th17/Treg-IL-10/IL-17 axis balance and their specific role in the occurrence and development of infectious pneumonia are not completely clear.Methods: Thirty specific-pathogen free Sprague Dawley (SD) rats were randomly divided into a control group for comparison and IPN model group. After the establishment of infectious pneumonia model, levels of FIB, PCT, hs-CRP, IL-10, and IL-17 in the serum of the two groups were measured using enzyme linked immunosorbent assay (ELISA), the pathological changes of lung tissue were observed using hematoxylin and eosin (HE) staining, the number of Treg and Th17 cells and the ratio of Th17/Treg in serum were detected using flow cytometry, and the levels of retinoic acid-related orphan receptor γt and forkhead box P3 (FOXP3) in lung tissue were detected using reverse transcription polymerase chain reaction (RT-PCR) and western blot. Results:The results showed that the serum levels of FIB, PCT, hs-CRP, Th17 cell number, Th17/Treg ratio, left lung dry and wet weight, lung tissue wet/dry ratio, lung pathology score and IL-17 level in the model group were significantly higher than those in the control group, while the number of Treg cells and the level of IL-10 in the model group were significantly lower than those in the control group. In addition, the expression of Foxp3mRNA and protein in lung tissue of model group decreased significantly, while the expression level of RORγ t mRNA and protein increased. Conclusions:In infectious pneumonia, the expression levels of FIB, PCT and hs-CRP are up-regulated, and Th17 cells are activated, Treg cells are inhibited, proinflammatory cytokine IL-17 expression is up-regulated, anti-inflammatory cytokine IL-10 expression is down-regulated, resulting in increased inflammatory response, thus promoting the occurrence and development of infectious pneumonia.

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Vertical Transmission of Mycoplasma pneumoniae Infection

Cited by 11 publications

References 19 publications

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Clinical implications of the genus Mycoplasma

Assessment of mechanisms of infectious pneumonia based on expression of fibrinogen, procalcitonin, high-sensitivity C-reactive protein expression, T helper 17 cells, regulatory T cells interleukin-10, and interleukin-17

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