Vertical transmission of human papillomavirus from infected mothers to their newborn babies and persistence of the virus in childhood

Implications of Human Papillomavirus Infections in the Biology of Head and Neck Cancers

“…They reported that the perinatal transmission of HPV DNA occurred in 24.5% of the cases studied (Rombaldi et al, 2009). Other studies also suggest that vertical transmission is common, occurring in 40% to 80% of cases (Puranen et al, 1996;Rintala et al, 2005b;Tseng et al, 1998). These high rates of vertical HPV transmission were not confirmed by several studies, which found that the risk of vertical transmission to the oral or genital mucosa of newborns was rare (1-5%) (Smith et al, 1995(Smith et al, , 2004b(Smith et al, , 2010Syrjänen & Puranen, 2000Tenti et al, 1999Watts et al, 1998).…”

“…At the age of 1-4 days, Smith et al in two studies found a low HPV incidence (from 0.9% to 1%) in the buccal swabs of neonates, whereas other studies showed a higher prevalence varying from 40% to 56% (Cason et al, 1995;Kaye et al, 1994;Pakarian et al, 1994;Tseng et al, 1998;Smith et al, 1995Smith et al, , 2004b. Similarly, the detection rate of HPV in infants between 6 weeks and 6 months after delivery varied between 0% and 62% (Cason et al, 2005;Fredericks et al, 1993;Pakarian et al, 1994;Watts et al, 1998) and among 3-year-old children varied between 10% and 40% (Kojima et al, 2003;Puranen et al, 1996Puranen et al, , 1997Szydlowski et al, 2004). Mant et al studied the acquisition and the clearance of HPV in the buccal mucosa of 4-to 9-year-old children and showed that, during a 30-month follow-up, 63% of 19 initially HPV-negative children acquired new HPV16 infection, while 40% of 22 initially HPVpositive children cleared the virus (Mant et al, 2003).…”

“…According to the age studied, there are variations in the prevalence rate. In nasopharyngeal aspirates collected immediately after birth, the detection rate of HPV varies from 1.5% to 37% (Cason et al, 1995;Castellsague et al, 2009;Mazzatenta et al, 1996;Puranen et al, 1996Puranen et al, , 1997Rintala et al, 2005aRintala et al, , 2005bRombaldi et al, 2008;Sedlacek et al, 1989;Tenti et al, 1997Tenti et al, , 1999Watts et al, 1998). At the age of 1-4 days, Smith et al in two studies found a low HPV incidence (from 0.9% to 1%) in the buccal swabs of neonates, whereas other studies showed a higher prevalence varying from 40% to 56% (Cason et al, 1995;Kaye et al, 1994;Pakarian et al, 1994;Tseng et al, 1998;Smith et al, 1995Smith et al, , 2004b.…”

HPV and oral lesions: preventive possibilities, vaccines and early diagnosis of malignant lesions

“…unknown reasons there is a small percentage of the population whose immune system does not recognize this as a threat and it is allowed to prosper (22)(23)(24)(25)(26)(27).…”

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

“…According to the age studied, there are variations in the prevalence rate. In nasopharyngeal aspirates collected immediately after birth, the detection rate of HPV varies from 1.5% to 37% (Cason et al, 1995;Castellsague et al, 2009;Mazzatenta et al, 1996;Puranen et al, 1996Puranen et al, , 1997Rintala et al, 2005aRintala et al, , 2005bRombaldi et al, 2008;Sedlacek et al, 1989;Tenti et al, 1997Tenti et al, , 1999Watts et al, 1998). At the age of 1-4 days, Smith et al in two studies found a low HPV incidence (from 0.9% to 1%) in the buccal swabs of neonates, whereas other studies showed a higher prevalence varying from 40% to 56% (Cason et al, 1995;Kaye et al, 1994;Pakarian et al, 1994;Tseng et al, 1998;Smith et al, 1995Smith et al, , 2004b.…”