Vertical transmission of hepatitis C virus infection: Usefulness of viremia detection in HIV-seronegative hepatitis C virus–seropositive mothers

The management of HCV infected pregnant women and their children European paediatric HCV network

“…High viral load during pregnancy or at delivery is associated with an increased vertical transmission risk [24][25][26][27][28][29][30]. However, probably because of considerable fluctuations in viraemia during pregnancy [31][32][33], women Fig.…”

Mother–To–Infant Transmission of Hepatitis C Virus

“…In 5 studies, including several in which maternal titer of HCV RNA was reported as having no bearing on rate of transmission, the timing of serum collection was unclear. 18,33,[41][42][43]45 …”

Discordant outcome of perinatal transmission of hepatitis C in twin pregnancies

“…Vertical transmission of hepatitis C virus (HCV) from HCV-only infected mothers to their babies occurs in 4-10% of pregnancies and is associated with high maternal viraemia with levels >10 6 genome copies/ml more likely to transmit virus (Dal Molin et al, 2002;European Paediatric HCV Network, 2001;Giacchino et al, 1998;Gibb et al, 2000;Granovsky et al, 1998;Lin et al, 1994;Matsubara et al, 1995;Resti et al, 1998;Steininger et al, 2003;Thomas et al, 1998;Tova et al, 1997;Zanetti et al, 1998). Coinfection with HIV is an additional risk (European Paediatric HCV Network, 2001;Gibb et al, 2000;Tova et al, 1997;Zanetti et al, 1998).…”