Vertical Spatial Orientation in Patients with Parkinsonism under the State of Single “Dry” Immersion and a Course of Immersions

Meigal, Alexander; Tretyakova, Olga G.; Gerasimova-Meigal, Liudmila; Саенко, И. В.

doi:10.1134/s0362119721020079

Cited by 5 publications

(10 citation statements)

References 27 publications

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“…Thus, this study closed an important gap in ground-based space experiments, since most of them last for longer periods (several hours, days, weeks) and attract mostly younger healthy subjects. For this reason, this study is one of the few exploratory ones in a row with our previous studies (Meigal et al, 2018(Meigal et al, , 2020(Meigal et al, , 2021a in space neuroscience and space suborbital tourism.…”

Section: Prospectivementioning

confidence: 95%

“…The study enrolled 20 subjects with PD, 13 men and seven women. These subjects have participated in our previously published studies (Meigal et al, 2018(Meigal et al, , 2021aMiroshnichenko et al, 2018), where one can find their individual clinical and anthropological characteristics and medication. General characteristic of the subjects is presented in Table 1.…”

Section: Participantsmentioning

confidence: 99%

“…The condition of DI was induced by means of the "Medical Facility of Artificial Weightlessness" (MEDSIM, Center for Aerospace Medicine and Technologies, State Scientific Center of Russian Federation "Institute of Biomedical Problems, " Moscow, Russia) housed in Petrozavodsk State University (Petrozavodsk, Russia). A detailed description of the procedure of DI applied to the group of PD subjects is available in our earlier papers (Meigal et al, 2018(Meigal et al, , 2021aMiroshnichenko et al, 2018). The short-term DI session lasted 45-min.…”

Section: The DI Interventionmentioning

confidence: 99%

“…Earlier we have shown that ground-based microgravity modeled with a short-term session of DI diminished tremor and muscle rigidity in Parkinson's disease (PD; Meigal et al, 2018Meigal et al, , 2021aMiroshnichenko et al, 2018), which can be attributed to the well-established atonia-inducing effect of DI on the skeletal muscle of healthy subjects (Navasiolava et al, 2011;Amirova et al, 2020). Additionally, the performance of the visual-motor reaction time tasks with higher cognition demand has improved after a program of DI sessions (Meigal et al, 2021b).…”

Section: Introductionmentioning

confidence: 98%

“…Additionally, the performance of the visual-motor reaction time tasks with higher cognition demand has improved after a program of DI sessions (Meigal et al, 2021b). However, these positive effects do not translate to quality of life and activity of daily living, or body balance (Meigal et al, 2018(Meigal et al, , 2021a).…”

Section: Introductionmentioning

confidence: 99%

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Autonomic Function in Parkinson's Disease Subjects Across Repeated Short-Term Dry Immersion: Evidence From Linear and Non-linear HRV Parameters

et al. 2021

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Several studies have shown that “dry” immersion appears as a promising method of rehabilitation for Parkinson's disease. Still, little is known about the cardiovascular reaction in “dry” immersion (DI), especially in Parkinson's disease (PD). Therefore, this study was aimed to evaluate the effect of repeated 45-min DI sessions on autonomic function in subjects with PD. The study group consisted of 20 subjects with PD [13 men, seven women, aged 51–66 years old, Hoehn & Yahr (H&Y) staged 1–3] were enrolled in the study according to inclusion and non-inclusion criteria. The DI program was comprised of seven 45-min DI sessions, applied within 25–30 days. Blood pressure (BP), heart rate (HR), and electrocardiogram (ECG) in the standard lead II were recorded at 1st, 4th, and 7th DI, before, on the 15, 30, and 40th min of DI session. Autonomic function was assessed with analysis of heart rate variability (HRV) using Kubios Standard version 2 software. Linear (time- and frequency-domain) and non-linear (correlation dimension, entropies, DFA1 and DFA2, percent of determinism, and recurrence) were computed. At baseline condition, time- and frequency-domain HRV parameters showed low variability of HR, which indicates reduced autonomic neurogenic control of HR. Throughout the DI session, systolic and diastolic BP has decreased by 5–7 mm Hg (p < 0.001), and time- and frequency-domain parameters of HRV have significantly increased, what can be regarded as compensatory mechanisms of hemodynamics during DI. The structure of the regulatory input to the heart seen by HRV was characterized by low complexity and reduced autonomic neurogenic control of HR. Across the program of DI sessions, the hypotensive effect was documented, but no notable modification of the HRV-parameters was found. The absence of long-term modification of the studied parameters can be attributed both to deconditioning environmental effect of DI and limited adaptation of the organism due to neurodegeneration in PD. That should be taken into consideration when planning rehabilitation measures in subjects of older age and chronic somatic diseases with modeled microgravity.

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Section: Prospectivementioning

confidence: 95%

Section: Participantsmentioning

confidence: 99%