Vertical mobility and cotton tolerance to trifludimoxazin, a new protoporphyrinogen oxidase-inhibiting herbicide, in three West Texas soils

Abstract

Trifludimoxazin, a new protoporphyrinogen oxidase-inhibiting herbicide, is being evaluated for possible use as a soil-residual active herbicide treatment in cotton for control of small-seeded annual broadleaf weeds. Laboratory and greenhouse studies were conducted to compare vertical mobility and cotton tolerance of trifludimoxazin to flumioxazin and saflufenacil, which are two currently registered protoporphyrinogen oxidase-inhibiting herbicides for use in cotton, in three West Texas soils. Vertical soil mobility of trifludimoxazin was similar to flumioxazin in Acuff loam and Olton loam soils, but was more mobile than flumioxazin in the Amarillo loamy sand soil. The depth of trifludimoxazin movement following a 2.5 cm irrigation event ranged from 2.5 to 5.0 cm in all soils, which would not allow for crop selectivity based on herbicide placement as ideal cotton seeding depth is from 0.6 to 2.54 cm deep. Greenhouse studies indicated that preemergence treatments were more injurious than the 14 d preplant treatment when summarized across soils for the three herbicides (43% and 14% injury, respectively). No differences in visual cotton response or dry weight was observed following trifludimoxazin preplant as compared to the nontreated control within each of the three West Texas soils and was similar to the flumioxazin preplant across soils. Based on the results of these studies, a use pattern for trifludimoxazin in cotton may be established with the utilization of a >14 d preplant restriction prior to cotton planting.

Australia’s first case of glyphosate-resistant tall fleabane (Conyza sumatrensis) and alternative herbicide options for its control

“…Limited information is available to compare the response of tall fleabane to saflufenacil þ trifludimoxazin-based herbicide mixtures. Trifludimoxazin is the newest herbicide among these PPO inhibitors, and it is being evaluated for possible use as a soil-residual herbicide treatment in cotton (Asher et al 2021).…”

Design, Synthesis and Proteomics-Based Analysis of Novel Triazinone Derivatives Containing Amide Structures as Safer Protoporphyrinogen IX Oxidase Inhibitors

“…12 Therefore, trifludimoxazin is adept at controlling weed species resistant to PPO-targeted herbicides, such as those from Amaranthus spp. and Ambrosia spp., that other PPO inhibitors cannot control 13 (Figure 1a). Despite the success of trifludimoxazin in resistant-weed control, the herbicide safeners are usually matched to produce considerable tolerance in nontarget crops, such as wheat, corn, and soybeans.…”

Discovery of Novel N-Phenyltriazinone Derivatives Containing Oxime Ether or Oxime Ester Moieties as Promising Protoporphyrinogen IX Oxidase Inhibitors

“…Tiafenacil and Epyrifenacil (Figure ) are two nonselective herbicides with a broad herbicidal spectrum and fast onset advantages, developed by Dongbu Hannong Chemical and Sumitomo Chemical Corporation Limited . Trifludimoxazin (Figure ) is the first PPO inhibitor herbicide with a triazinone structure with the unique binding mode to PPO and has a new mechanism of action to control some PPO-resistant weeds. − In 2004, Koch et al reported the crystal structure of the Nicotiana tobacco PPO ( Nt PPO) complex with the phenylpyrazole inhibitor 4-bromo-3-(5′-carboxy-4′-chloro-2′-fluoro-phenyl)-1-methyl-5-trifluoromethyl-pyrazole (INH). There are three interaction modes between Nt PPO and INH (Figure ) including the π–π interaction between Phe392 and the pyrazole ring of INH, hydrophobic interactions of Leu372 and Leu356 to the benzene ring, and hydrogen-bonding interactions between Arg98 and the carbonyl group of INH, which provides a new vision for the design of novel PPO inhibitors …”