Vertebrate centromere architecture: from chromatin threads to functional structures
Lorena Andrade Ruiz,
Geert J. P. L. Kops,
Carlos Sacristan
Abstract:Centromeres are chromatin structures specialized in sister chromatid cohesion, kinetochore assembly, and microtubule attachment during chromosome segregation. The regional centromere of vertebrates consists of long regions of highly repetitive sequences occupied by the Histone H3 variant CENP-A, and which are flanked by pericentromeres. The three-dimensional organization of centromeric chromatin is paramount for its functionality and its ability to withstand spindle forces. Alongside CENP-A, key contributors t… Show more
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