Vertebral Remodeling in Eosinophilic Granuloma of the Spine

Raab, Peter; Hohmann, Felix; Kühl, Joachim; Krauspe, Rüdiger

doi:10.1097/00007632-199806150-00011

Cited by 88 publications

(65 citation statements)

References 10 publications

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“…Compiling data from the eight largest case series of the spinal LCH reveals that 49 of 180 cases (27.2%) had multiple vertebrae lesions [3,5,11,13,20,23,26,27,35].…”

Section: Meta-analysis Literature Review and Discussionmentioning

confidence: 99%

“…Yeom et al [35] believed that close observation with frequent clinical and radiologic examination is more appropriate than vertebral biopsy in patients with typical vertebral lesions, without evidence or suspicion of malignancy. But some other authors preferred biopsy [5,26].…”

Section: Biopsymentioning

confidence: 99%

“…A complete clinical, laboratory and radiologic work-up is also necessary for adequate treatment based on the extent of the LCH [26]. It is recommended that a technetium bone scan or a skeletal survey be performed early during the evaluation of every case with a suspected spinal lesion.…”

Section: Bone Scanmentioning

confidence: 99%

“…Second, vertebral growth disturbance by radiotherapy is possible theoretically, but has never been reported [11,35]. Raab et al [26] suggested a dosage between 8 and 12 Gy for children which was only indicated when immobilization failed to relieve the symptoms. This limited dosage could provide rapid and reliable pain relief without altering reconstitution potential and spinal growth.…”

Section: Radiotherapymentioning

confidence: 99%

“…A search of the MEDLINE databank located 13 studies and totally 50 cases of LCH with multiple spinal lesions [1,3,5,11,13,20,21,23,26,27,[32][33][34][35]. We reported five additional cases and a meta-analysis of all cases was also performed.…”

Section: Introductionmentioning

confidence: 99%

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Langerhans cell histiocytosis with multiple spinal involvement

et al. 2010

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To stress the clinical and radiologic presentation and treatment outcome of Langerhans cell histiocytosis (LCH) with multiple spinal involvements. A total of 42 cases with spinal LCH were reviewed in our hospital and 5 had multifocal spinal lesions. Multiple spinal LCH has been reported in 50 cases in the literature. All cases including ours were analyzed concerning age, sex, clinical and radiologic presentation, therapy and outcome. Of our five cases, three had neurological symptom, four soft tissue involvement and three had posterior arch extension. Compiling data from the eight largest case series of the spinal LCH reveals that 27.2% multiple vertebrae lesions. In these 55 cases, there were 26 female and 29 male with the mean age of 7.4 years (range 0.2-37). A total of 182 vertebrae were involved including 28.0% in the cervical spine, 47.8% in thoracic and 24.2% in the lumbar spine. Extraspinal LCH lesion was documented in 54.2% cases, visceral involvement in 31.1% and vertebra plana in 50% cases. Paravertebral and epidural extension were not documented in most cases. Pathological diagnosis was achieved in 47 cases including 8 open spine biopsy. The treatment strategy varied depending on different hospitals. One patient died, two had recurrence and the others had no evidence of the disease with an average of 7.2 years (range 1-21) of follow-up. Asymptomatic spinal lesions could be simply observed with or without bracing and chemotherapy is justified for multiple lesions. Surgical decompression should be reserved for the uncommon cases in which neurologic compromise does not respond to radiotherapy or progresses too rapidly for radiotherapy.

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“…Compiling data from the eight largest case series of the spinal LCH reveals that 49 of 180 cases (27.2%) had multiple vertebrae lesions [3,5,11,13,20,23,26,27,35].…”

Section: Meta-analysis Literature Review and Discussionmentioning

confidence: 99%

Section: Biopsymentioning

confidence: 99%

Section: Bone Scanmentioning

confidence: 99%