Vertebral pattern and morphology is determined during embryonic segmentation
Kevin M. Serra,
Christina Vyzas,
Sarah Shehreen
et al.
Abstract:BackgroundThe segmented nature of the adult vertebral column is based on segmentation of the paraxial mesoderm during early embryogenesis. Disruptions to embryonic segmentation, whether caused by genetic lesions or environmental stress, result in adult vertebral pathologies. However, the mechanisms linking embryonic segmentation and the details of adult vertebral morphology are poorly understood.ResultsWe induced border defects using two approaches in zebrafish: heat stress and misregulation of embryonic segme… Show more
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