Vertebral osteomyelitis in an infant presenting with pseudotumor and narrowing of the spinal canal

Tröbs, Ralf-Bodo; Handrïck, W; Lotz, I.; Bankwitz, Cathleen; Tannapfel, Andrea

doi:10.1007/s00383-005-1378-9

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…All types of microorganisms, including viruses, parasites, fungi, and bacteria, can cause spondylodiscitis. 3,7,8,[12][13][14][15] S. aureus is responsible for 80-90% of cases of pyogenic osteomyelitis. 2,7,8 Its propensity to infect the bone may be related to the fact that it expresses receptors for bone matrix components such as collagen, thereby facilitating its adherence to bone tissue.…”

Section: Discussionmentioning

confidence: 99%

Linezolid therapy for pediatric thoracic spondylodiscitis due to Staphylococcus aureus sepsis

Krzysztofiak

Pagnotta

Lancella

et al. 2010

International Journal of Infectious Diseases

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We report the case of an immunocompetent child with spondylodiscitis as a result of staphylococcal sepsis, which was successfully treated with linezolid. The patient was admitted with fever and circumferential swelling in the paradorsal region, which was evident only in the flexed back position. A chest X-ray showed a pleural effusion with pneumonitis and dorsal kyphosis. Following the yield of Staphylococcus aureus from blood cultures, the initial therapy of ceftriaxone and amikacin was changed to vancomycin. However, the dorsal swelling increased further and imaging investigations showed destruction of the vertebral bodies D8-D10 and surrounding tissue swelling. Vancomycin was changed to linezolid, and the patient began to improve; a full recovery was made. Our case suggests that even if spondylodiscitis is rare in the pediatric age-group, particularly as a complication of staphylococcal sepsis, early diagnosis and prompt and appropriate therapy are important to prevent severe complications.

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Section: Discussionmentioning

confidence: 99%

Linezolid therapy for pediatric thoracic spondylodiscitis due to Staphylococcus aureus sepsis

Krzysztofiak

Pagnotta

Lancella

et al. 2010

International Journal of Infectious Diseases

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“…[46][47][48][49] Our institution has extensive experience with EACA, as more than 1500 spinal deformity cases have been surgically treated since 1998, but there have been no neurological or other complications directly related to its use. Our experience includes a prospective preliminary study, a randomized double-blinded study, a fibrinogen study, and anterior and posterior spinal fusion studies, as well as a study on neuromuscular disorders.…”

Section: 45mentioning

confidence: 99%

“…48 Considering the aforementioned reports, the underlying hyperfibrinogenemia cannot be disregarded as a probable mechanism for development of intracranial hypertension in patients with spinal deformity after surgical correction in which antifibrinolytic therapy has been used.…”

Section: 45mentioning

confidence: 99%

Idiopathic intracranial hypertension following spinal deformity surgery in children

Kunes¹,

Thompson²,

Manjila

et al. 2011

FOC

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Idiopathic intracranial hypertension (IIH) after pediatric spinal deformity surgery has not been previously reported. The authors conducted a retrospective analysis of more than 1500 pediatric spinal surgeries performed between 1992 and 2011. From their analysis, they report on 3 adolescent patients who underwent uncomplicated segmental spinal instrumentation for pediatric spinal deformity correction and subsequently developed features of IIH. The common variables in these 3 patients were adolescent age, spinal deformity, being overweight, symptom onset within 2 weeks postoperatively, significant estimated blood loss, and intraoperative use of ε–aminocaproic acid (antifibrinolytic) injection. The authors postulate that the development of IIH could be the result of venous outflow obstruction due to derangement of the epidural venous plexus during surgery. The use of ε–aminocaproic acid could potentially have the risk of causing IIH, probably mediated through hyperfibrinogenemia, although there have not been published cases in the neurosurgical, orthopedic, cardiac, or general surgical literature. Idiopathic intracranial hypertension after spinal deformity correction is a condition that should be recognized by neurosurgeons and orthopedic surgeons, because appropriate intervention with early medical therapy can lead to a satisfactory clinical outcome.

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Pediatric Spinal Infections (Acute)

Alanay

Yılgör

2022

The Growing Spine

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Vertebral osteomyelitis in an infant presenting with pseudotumor and narrowing of the spinal canal

Cited by 5 publications

References 15 publications

Linezolid therapy for pediatric thoracic spondylodiscitis due to Staphylococcus aureus sepsis

Linezolid therapy for pediatric thoracic spondylodiscitis due to Staphylococcus aureus sepsis

Idiopathic intracranial hypertension following spinal deformity surgery in children

Pediatric Spinal Infections (Acute)

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