Vertebral osteomyelitis caused by non-tuberculous mycobacteria: case reports and review

Shimizu, Hiroyuki; Mizuno, Yasutaka; Nakamura, Itaru; Fukushima, Shinji; Endo, Kenji; Matsumoto, Tetsuya

doi:10.1007/s10156-013-0550-8

Cited by 32 publications

(28 citation statements)

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“…Osteomyelitis is an extremely rare presentation of M. kansasii infection; there are only few reported cases of vertebral ostemoyelitis [5], and even fewer cases of an extra-vertebral osteomyelitis [5]. Skeletal system involvement usually presents as long-standing painful swollen joint or back pain in cases of vertebral osteomyelitis.…”

Section: Discussionmentioning

confidence: 99%

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IsolatedMycobacterium kansasiiwound infection and Osteomyelitis in an immunocompetent patient

2016

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Mycobacterium kansasii is a slow growing acid-fast non-tuberculosis mycobacterium. It most commonly causes pulmonary disease with tuberculosis-like manifestations. Mycobacterium kansasii-induced skin and soft tissue infections (SSTIs) are very uncommon, especially in the absence of obvious risk factors. In this report, we present a rare case of M. kansasii-associated SSTI complicated by tendonitis and osteomyelitis in an immunocompetent patient. This case highlights the importance of considering non-tuberculosis mycobacteria while investigating chronic, relapsing, non-healing SSTIs and osteomyelitis. Proper pharmacotherapy, along with surgical debridement, is the optimal management to avoid relapse and the production of resistant species.

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Section: Discussionmentioning

confidence: 99%

“…Osteomyelitis is even less encountered than SSTIs, especially in the absence of obvious risk factors [4]. Only few cases in the medical literature reported M. kansasii -induced osteomyelitis in both healthy and immunocompromised patients [5]. …”

Section: Introductionmentioning

confidence: 99%

IsolatedMycobacterium kansasiiwound infection and Osteomyelitis in an immunocompetent patient

2016

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“…His blood cultures were negative in a previous episode of presumed osteomyelitis. Though rare, NTM have been reported to cause transient bacteremia and osteomyelitis in intravenous drug users (8).…”

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confidence: 99%

First Report of Mycobacterium canariasense Catheter-Related Bacteremia in the Americas

et al. 2014

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e Mycobacterium canariasense is a recently described late-pigmenting, rapidly growing mycobacterium linked to bacteremia in patients with underlying malignant diseases. We report a case of M. canariasense infection in a patient from Massachusetts with underlying diffuse B cell lymphoma, which was identified both by multilocus sequence typing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). To our knowledge, this is the first description after its original identification in Spain and the first report of this opportunistic pathogen in the Americas. CASE REPORT We report a case of catheter-related bacteremia by Mycobacterium canariasense in a 42-year-old patient from Massachusetts with a history of intravenous drug abuse, hepatitis C, and diffuse B cell lymphoma.The patient presented complaining of fever (101.2°F), chills, vomiting, and nausea since 2 days prior to his admission. Six weeks earlier, he had been admitted and diagnosed with presumptive osteomyelitis of the sacroiliac joint for which he received empirical treatment with intravenous vancomycin for 6 weeks, completed a week prior to admission. Multiple sets of blood cultures were negative during this admission. At that time, a bone marrow biopsy was also performed for pancytopenia, and the patient was diagnosed with diffuse large B cell lymphoma with plasmacytoid features. He received two cycles of antineoplastic chemotherapy with cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisolone (R-CHOP), with the second cycle administered 2 days prior to admission and coinciding with the onset of fever.He did not report rashes, headache, cough, or gastrointestinal complaints, and his prior medical history was significant for bipolar and major depressive disorder as well as essential hypertension. Liver function tests were monitored for hepatitis C exacerbation but were within reference limits. A complete blood count was notable for total leukocytes of 5,150/mm 3 , with 50.5% neutrophils and 16.8% lymphocytes, decreased hemoglobin of 8.6 g/dl, hematocrit of 31.2%, and a normal platelet count of 381,000/mm 3 . Blood urea nitrogen, serum creatinine, and glucose were within reference ranges.Shortly after admission during a febrile episode, blood cultures were drawn and the peripherally inserted central catheter was removed and sent for culture using the roll-plate semiquantitative technique described by Maki et al. (1). The blood cultures in the aerobic bottles grew Candida dubliniensis, Candida albicans, Pseudomonas aeruginosa, and numerous Gram-variable rods. Candida species were determined with both the API 20C AUX and matrixassisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) systems. The catheter tip grew numerous Gram-variable rods as well as a group B beta-streptococcus.The Gram-variable rods (which grew from 4/4 bottles collected in two sets 3 days apart) grew on Lowenstein-Jensen (LJ) medium after 4 days (at 37°C) and revealed small, smooth, nonpigmented coloni...

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“…It is likely that bath water is a possible source of MAC infection, at least in Japan (26). Indeed, the M. avium complex was the most common cause of infections due to nontuberculous mycobacteria not only in Japan (24,25) but also worldwide (27,28).…”

Section: Resultsmentioning

confidence: 99%

Bath Water Contamination with Legionella and Nontuberculous Mycobacteria in 24-Hour Home Baths, Hot Springs, and Public Bathhouses of Nagano Prefecture, Japan

2014

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Vertebral osteomyelitis caused by non-tuberculous mycobacteria: case reports and review

Cited by 32 publications

References 10 publications

IsolatedMycobacterium kansasiiwound infection and Osteomyelitis in an immunocompetent patient

IsolatedMycobacterium kansasiiwound infection and Osteomyelitis in an immunocompetent patient

First Report of Mycobacterium canariasense Catheter-Related Bacteremia in the Americas

Bath Water Contamination with Legionella and Nontuberculous Mycobacteria in 24-Hour Home Baths, Hot Springs, and Public Bathhouses of Nagano Prefecture, Japan

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