Vertebral Osteomyelitis

Zimmerli, Werner

doi:10.1056/nejmcp0910753

Cited by 524 publications

(518 citation statements)

References 42 publications

Supporting

Mentioning

458

Contrasting

Unclassified

Order By: Relevance

“…It can result from hematogenous spread of pathogens following a distant infection, in continuity from neighboring tissues or after spinal surgery [4]. Elderly patients and those with immunosuppressive diseases, renal failure, or intravenous drug abuse are at particular risk [5].…”

Section: Musculoskeletal Systemmentioning

confidence: 99%

“…Diagnosis can be challenging as patients may present with nonspecific symptoms such as back or abdominal pain [6], fever, malaise and/or elevated inflammatory blood values while blood cultures often return negative [5]. Moreover, symptoms can be masked by previous (self-) medication, resulting in a delay of correct diagnosis of up to several months [4].…”

Section: Musculoskeletal Systemmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic Yield of Multidetector Computed Tomography in Patients with Acute Spondylodiscitis

Rausch

Bannas

Schoen

et al. 2017

Fortschr Röntgenstr

View full text Add to dashboard Cite

ZUSAMMENFASSUNGZiel Evaluation der diagnostischen Genauigkeit der MultidetektorComputertomografie (MDCT) bei der akuten Spondylodiszitis. This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.accuracy was 87 %. Accuracy was higher for CECT (89 %) than for NECT (84 %), however without statistical significance (p = 0.55).MDCT detected 90 % of paravertebral abscesses (34/38), but only 6 % of epidural abscesses (2/36). Conclusion

show abstract

Section: Musculoskeletal Systemmentioning

confidence: 99%

Section: Musculoskeletal Systemmentioning

confidence: 99%

Diagnostic Yield of Multidetector Computed Tomography in Patients with Acute Spondylodiscitis

Rausch

Bannas

Schoen

et al. 2017

Fortschr Röntgenstr

View full text Add to dashboard Cite

show abstract

“…Since it is often a complication of a distant infection causing bacteremia, the relatively non-specific array of symptoms of vertebral osteomyelitis may be initially dominated by the primary infection [1]. Consequently, a considerable delay between the onset of back pain and the diagnosis of vertebral osteomyelitis may develop [2,3].…”

Section: Introductionmentioning

confidence: 99%

Extensive thoracolumbosacral vertebral osteomyelitis after Lemierre syndrome

et al. 2014

View full text Add to dashboard Cite

Purpose To present a unique case of multilevel vertebral osteomyelitis after Lemierre syndrome. Methods A previously healthy 27-year-old man presented in the Emergency Department in septic shock because of Lemierre syndrome for which he was subsequently treated with intravenous benzylpenicillin for 2 months. Two and a half months later, the patient was readmitted with severe back pain without neurological deficits or fever. Imaging revealed an extensive vertebral osteomyelitis of the complete thoracic, lumbar and sacral spine. Results Although the blood cultures obtained at the initial admission for Lemierre syndrome revealed Fusobacterium species and Streptococcus milleri, the cultures from the spinal biopsies remained negative. Histology of the spinal biopsies showed a purulent sclerosing osteomyelitis. The patient was successfully treated with intravenous piperacillin and tazobactam. Despite persisting back pain, no recurrence of infection was seen at 3 years of follow-up. Conclusion Lemierre syndrome and an extensive thoracolumbosacral vertebral osteomyelitis are rare but serious infections. Clinicians must maintain a high index of suspicion for infectious metastases leading to vertebral osteomyelitis when a patient presents with back pain after an episode of life-threatening septicaemia caused by Lemierre syndrome.

show abstract

“…The infection usually includes the long bones vertebrae, pelvis and clavicle. Various underlying medical conditions such as chronic renal disease, cancer and diabetes mellitus are associated with vertebrate osteomyelitis [15]. Around half of diabetic patients lead to peripheral neuropathy that may increase the risk of unrecognized infections [16], That will reduces the body's healing process and helps to grow the persistently soft tissue infection and open wound.…”

Section: Clinical Manifestationmentioning

confidence: 99%

Osteomyelitis: Identification and Management

Kumari¹

2016

MOJOR

View full text Add to dashboard Cite

ObjectiveOsteomyelitis is a severe inflammation within the bone, bone marrow and surrounding soft tissue, that develops secondary to infection with microbial organisms. The objective of this article is to present an over view regarding the identification and management of osteomyelitis. IntroductionOsteomyelitis is acute and chronic inflammatory process based upon the histopathological finding rather than duration of infection. Osteomyelitis occurring primarily in children and adolescents pathogenic micro-organism cause inflammation and infection of bone, which lead to osteomyelitis and signs appears after two weeks of infection (Figure 1) In chronic osteomyelitis necrotic bone is present and signs may not appear until six weeks of infection [1]. Osteomyelitis infection is based on open wound, haematogenous or direct bacterial inoculation inside bone [2]. Radio nuclides imagine have improved diagnostic accuracy and better orthopaedic techniques as well as use of some prophylactic regimens which help to minimize the risk of infection among osteomyelitis patient. EtiologyBacterial Staphylococcus is common infection which causes an acute and chronic haematogenous osteomyelitis. Different types of pathogens among children are Type A streptococcus, Streptococcus pneumonia, Kingella kingae and Type B streptococcal infection is mainly occur in infants [3]. Streptococcus aureus is the common pathogen in bone among adults. Progressively, methicillinresistant Staphylococcus aureus is separated from patients with osteomyelitis [4]. Other persistent cases may be caused by adjacent infection, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus epidermidis. Other reported cases of osteomyelitis are mycobacterial infections and fungal, these are rare and usually found in patients with weakened of body immunity [5]. PathogenesisOsteomyelitis may be occurring direct inoculation of causative organism in bone. Normal bone is highly resistant to infection occur in case of injury, trauma, and existence of foreign bodies [6]. Causative organism streptococcus aureus adhere to bone and expressing receptors for bone matrix. An insignificant skin infection emerge the serious infection such as sub-acute and acute bacterial endocarditic [7]. In children and adults, osteomyelitis mainly involves metaphysis of long bone, femur, proximal radius and hummers [8,9]. Penetrating injury and surgical contamination are the most common causes of direct inoculation osteomyelitis. Patent with severe vascular diseases often lead to osteomyelitis. Clinical ManifestationOsteomyelitis of acute haematogenous results from bacterial growth of bone. Most of the Children are more prone to infection because of developing of meta-physeal regions of the long bones, rich in blood supply and more prone to slight trauma. Acute haematogenous osteomyelitis in children occur about one-half of all patients who are under five years [10]. Children usually came with the symptom of exist fever, irritability, local erythema, swelling in soft tissues and tenderness bo...

show abstract

Vertebral Osteomyelitis

Cited by 524 publications

References 42 publications

Diagnostic Yield of Multidetector Computed Tomography in Patients with Acute Spondylodiscitis

Diagnostic Yield of Multidetector Computed Tomography in Patients with Acute Spondylodiscitis

Extensive thoracolumbosacral vertebral osteomyelitis after Lemierre syndrome

Osteomyelitis: Identification and Management

Contact Info

Product

Resources

About